HK1159100A1 - Method for preparing imrecoxib - Google Patents

Method for preparing imrecoxib

Info

Publication number
HK1159100A1
HK1159100A1 HK11113556.6A HK11113556A HK1159100A1 HK 1159100 A1 HK1159100 A1 HK 1159100A1 HK 11113556 A HK11113556 A HK 11113556A HK 1159100 A1 HK1159100 A1 HK 1159100A1
Authority
HK
Hong Kong
Prior art keywords
imrecoxib
preparing
dihydrofuranone
structural formula
easiness
Prior art date
Application number
HK11113556.6A
Inventor
Fuyao Zhang
Xiaoming Shen
Piaoyang Sun
Original Assignee
Unitris Biopharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unitris Biopharma Co Ltd filed Critical Unitris Biopharma Co Ltd
Publication of HK1159100A1 publication Critical patent/HK1159100A1/en

Links

Abstract

The invention relates to a method for preparing imrecoxib. In the method, with methylsulfonyl acetophenone as a raw material, the imrecoxib (structural formula I as shown in the specification) is prepared by synthesizing dihydrofuranone (structural formula II as shown in the specification) and then converting the dihydrofuranone (II) into pyrrolidone. The preparation method provided by the invention has the advantages of short synthetic route, low cost, simplicity in operation, easiness in separation and purification and suitability for large-scale production.
HK11113556.6A 2010-03-30 2011-12-15 Method for preparing imrecoxib HK1159100A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 201010136976 CN102206178B (en) 2010-03-30 2010-03-30 Method for preparing imrecoxib

Publications (1)

Publication Number Publication Date
HK1159100A1 true HK1159100A1 (en) 2012-07-27

Family

ID=44695273

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11113556.6A HK1159100A1 (en) 2010-03-30 2011-12-15 Method for preparing imrecoxib

Country Status (2)

Country Link
CN (1) CN102206178B (en)
HK (1) HK1159100A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104072467A (en) * 2014-07-07 2014-10-01 太仓博亿化工有限公司 Synthesis method of 5-chloro-2-benzofuranyl-p-chlorophenyl-one
CN104193664B (en) * 2014-08-22 2016-08-24 山东铂源药业有限公司 A kind of synthetic method of imrecoxib
CN107586268B (en) * 2016-07-07 2021-01-19 江苏恒瑞医药股份有限公司 Preparation method of dapoxib and intermediate thereof
CN109553564A (en) * 2017-09-25 2019-04-02 江苏恒瑞医药股份有限公司 A kind of purification process of imrecoxib
CN109678775B (en) * 2017-10-18 2020-12-04 江苏恒瑞医药股份有限公司 Crystal form of COX-2 selective inhibitor and preparation method thereof
CN108864003B (en) * 2018-06-15 2020-06-16 江苏美迪克化学品有限公司 Preparation method of dapoxib intermediate and dapoxib
CN108947884B (en) * 2018-06-29 2021-06-25 江苏美迪克化学品有限公司 Preparation method of ereoxib and intermediate thereof
CN111747879B (en) * 2019-03-29 2023-03-21 成都同心纵横生物医药有限公司 Large-process synthesis method of erexib

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4213931A1 (en) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
CN101386590A (en) * 2007-09-13 2009-03-18 中国医学科学院药物研究所 Pyrrolidone containing hydroxymethyl and carboxyl, preparation method and medicament composition and use thereof
CN101497580B (en) * 2009-01-09 2011-08-17 华南理工大学 HIV-1 inhibitor 2-pyrrolidinone derivative, as well as synthesizing method and use thereof

Also Published As

Publication number Publication date
CN102206178A (en) 2011-10-05
CN102206178B (en) 2013-04-10

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220403