HK1159100A1 - Method for preparing imrecoxib - Google Patents
Method for preparing imrecoxibInfo
- Publication number
- HK1159100A1 HK1159100A1 HK11113556.6A HK11113556A HK1159100A1 HK 1159100 A1 HK1159100 A1 HK 1159100A1 HK 11113556 A HK11113556 A HK 11113556A HK 1159100 A1 HK1159100 A1 HK 1159100A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- imrecoxib
- preparing
- dihydrofuranone
- structural formula
- easiness
- Prior art date
Links
Abstract
The invention relates to a method for preparing imrecoxib. In the method, with methylsulfonyl acetophenone as a raw material, the imrecoxib (structural formula I as shown in the specification) is prepared by synthesizing dihydrofuranone (structural formula II as shown in the specification) and then converting the dihydrofuranone (II) into pyrrolidone. The preparation method provided by the invention has the advantages of short synthetic route, low cost, simplicity in operation, easiness in separation and purification and suitability for large-scale production.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010136976 CN102206178B (en) | 2010-03-30 | 2010-03-30 | Method for preparing imrecoxib |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1159100A1 true HK1159100A1 (en) | 2012-07-27 |
Family
ID=44695273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11113556.6A HK1159100A1 (en) | 2010-03-30 | 2011-12-15 | Method for preparing imrecoxib |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN102206178B (en) |
HK (1) | HK1159100A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104072467A (en) * | 2014-07-07 | 2014-10-01 | 太仓博亿化工有限公司 | Synthesis method of 5-chloro-2-benzofuranyl-p-chlorophenyl-one |
CN104193664B (en) * | 2014-08-22 | 2016-08-24 | 山东铂源药业有限公司 | A kind of synthetic method of imrecoxib |
CN107586268B (en) * | 2016-07-07 | 2021-01-19 | 江苏恒瑞医药股份有限公司 | Preparation method of dapoxib and intermediate thereof |
CN109553564A (en) * | 2017-09-25 | 2019-04-02 | 江苏恒瑞医药股份有限公司 | A kind of purification process of imrecoxib |
CN109678775B (en) * | 2017-10-18 | 2020-12-04 | 江苏恒瑞医药股份有限公司 | Crystal form of COX-2 selective inhibitor and preparation method thereof |
CN108864003B (en) * | 2018-06-15 | 2020-06-16 | 江苏美迪克化学品有限公司 | Preparation method of dapoxib intermediate and dapoxib |
CN108947884B (en) * | 2018-06-29 | 2021-06-25 | 江苏美迪克化学品有限公司 | Preparation method of ereoxib and intermediate thereof |
CN111747879B (en) * | 2019-03-29 | 2023-03-21 | 成都同心纵横生物医药有限公司 | Large-process synthesis method of erexib |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4213931A1 (en) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
CN101386590A (en) * | 2007-09-13 | 2009-03-18 | 中国医学科学院药物研究所 | Pyrrolidone containing hydroxymethyl and carboxyl, preparation method and medicament composition and use thereof |
CN101497580B (en) * | 2009-01-09 | 2011-08-17 | 华南理工大学 | HIV-1 inhibitor 2-pyrrolidinone derivative, as well as synthesizing method and use thereof |
-
2010
- 2010-03-30 CN CN 201010136976 patent/CN102206178B/en active Active
-
2011
- 2011-12-15 HK HK11113556.6A patent/HK1159100A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN102206178A (en) | 2011-10-05 |
CN102206178B (en) | 2013-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20220403 |