HK1129884A1 - Process for production of radioactive fluorine-labeled organic compound - Google Patents

Process for production of radioactive fluorine-labeled organic compound

Info

Publication number
HK1129884A1
HK1129884A1 HK09107695.4A HK09107695A HK1129884A1 HK 1129884 A1 HK1129884 A1 HK 1129884A1 HK 09107695 A HK09107695 A HK 09107695A HK 1129884 A1 HK1129884 A1 HK 1129884A1
Authority
HK
Hong Kong
Prior art keywords
production
compound
formula
organic compound
radioactive fluorine
Prior art date
Application number
HK09107695.4A
Inventor
Akio Hayashi
Fumie Kurosaki
Masahito Toyama
Toshiyuki Shinmura
Emi Kaneko
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of HK1129884A1 publication Critical patent/HK1129884A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Provided is a process for production of [ 18 F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for production of a radioactive fluorine-labeled organic compound, which comprises: a deesterification step of retaining, in a reverse-phase column, a compound represented by Formula (1): wherein R 1 is a linear or branched C 1 -C 10 alkyl chain or an aromatic substituent; and R 2 is a protecting group; charging the column with an alkaline solution to deesterify the compound, and subsequently discharging the alkaline solution from the column to obtain a compound represented by Formula (2): wherein X is sodium or potassium; and a deprotection step of deprotecting the amino-protecting group of the compound obtained in the deesterification step to obtain a compound represented by Formula (3):
HK09107695.4A 2006-05-11 2009-08-21 Process for production of radioactive fluorine-labeled organic compound HK1129884A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006132089 2006-05-11
PCT/JP2007/059459 WO2007132689A1 (en) 2006-05-11 2007-05-07 Process for production of radioactive fluorine-labeled organic compound

Publications (1)

Publication Number Publication Date
HK1129884A1 true HK1129884A1 (en) 2009-12-11

Family

ID=38693787

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09107695.4A HK1129884A1 (en) 2006-05-11 2009-08-21 Process for production of radioactive fluorine-labeled organic compound

Country Status (19)

Country Link
US (1) US7897811B2 (en)
EP (1) EP2017258B1 (en)
JP (1) JP4550141B2 (en)
KR (1) KR101317258B1 (en)
CN (1) CN101443307B (en)
AT (1) ATE549312T1 (en)
AU (1) AU2007251015B2 (en)
BR (1) BRPI0711144B1 (en)
CA (1) CA2651786C (en)
DK (1) DK2017258T3 (en)
ES (1) ES2380372T3 (en)
HK (1) HK1129884A1 (en)
IL (1) IL195187A (en)
NO (1) NO341173B1 (en)
NZ (1) NZ572936A (en)
PT (1) PT2017258E (en)
RU (1) RU2434846C2 (en)
TW (1) TWI389872B (en)
WO (1) WO2007132689A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080071146A (en) 2005-11-29 2008-08-01 니혼 메디피직스 가부시키가이샤 Precursor compound of radioactive halogen labeled organic compound
BRPI0720465B8 (en) * 2006-12-27 2021-07-27 Nihon Mediphysics Co Ltd process for producing precursor compound for radioactive halogen labeled organic compound
TWI406674B (en) * 2007-02-13 2013-09-01 Nihon Mediphysics Co Ltd Method for manufacturing diagnostic radiographic diagnostic agents
US8269035B2 (en) * 2007-12-19 2012-09-18 Nihon Medi-Physics Co., Ltd. Process for production of radioactive-fluorine-labeled organic compound
GB0812923D0 (en) * 2008-07-15 2008-08-20 Isis Innovation Preparation of flourine-labelled compounds
JP6018578B2 (en) * 2010-11-29 2016-11-02 ジーイー・ヘルスケア・リミテッド Production of PET precursor
MX2013007186A (en) * 2010-12-20 2013-07-12 Ge Healthcare Ltd Purification of precursor compound by crystallisation.
GB201021530D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
GB201021523D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
AU2012356846B2 (en) * 2011-12-21 2017-07-27 Ge Healthcare Limited 18F - Fluciclovine compositions in citrate buffers
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
GB201214220D0 (en) 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis
GB2561122B (en) * 2012-12-21 2019-07-17 Ge Healthcare Ltd Composition comprising [18F]-Fluciclovine
GB201305687D0 (en) 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
JP6755862B2 (en) * 2015-06-05 2020-09-16 日本メジフィジックス株式会社 Equipment and method for producing radioactively labeled compounds
JP6485914B2 (en) * 2015-10-28 2019-03-20 日本メジフィジックス株式会社 Method for producing flutemetamol
CN106770883B (en) * 2017-01-03 2019-01-29 原子高科股份有限公司 A kind of fluorine [18F] change sodium injection top coal drawing thin layer chromatography

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808146A (en) 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
BE1010280A3 (en) 1996-05-02 1998-05-05 Coincidence S A Method and apparatus for synthesis of 2- [18f] fluoro-2-d-glucose-deoxy.
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
JP4979945B2 (en) * 2003-09-30 2012-07-18 日本メジフィジックス株式会社 Method for producing radioactive fluorine compound

Also Published As

Publication number Publication date
RU2008148851A (en) 2010-06-20
CN101443307A (en) 2009-05-27
TWI389872B (en) 2013-03-21
WO2007132689A1 (en) 2007-11-22
IL195187A0 (en) 2009-08-03
DK2017258T3 (en) 2012-07-09
BRPI0711144A2 (en) 2011-08-23
KR20090034805A (en) 2009-04-08
KR101317258B1 (en) 2013-10-14
EP2017258B1 (en) 2012-03-14
RU2434846C2 (en) 2011-11-27
TW200811084A (en) 2008-03-01
AU2007251015A1 (en) 2007-11-22
ES2380372T3 (en) 2012-05-11
IL195187A (en) 2013-04-30
NO20085076L (en) 2009-02-10
JPWO2007132689A1 (en) 2009-09-24
AU2007251015B2 (en) 2011-09-01
JP4550141B2 (en) 2010-09-22
CN101443307B (en) 2012-05-16
US20090198085A1 (en) 2009-08-06
CA2651786A1 (en) 2007-11-22
CA2651786C (en) 2014-11-04
BRPI0711144B1 (en) 2017-03-28
NZ572936A (en) 2011-01-28
ATE549312T1 (en) 2012-03-15
PT2017258E (en) 2012-04-12
EP2017258A4 (en) 2011-05-25
EP2017258A1 (en) 2009-01-21
US7897811B2 (en) 2011-03-01
NO341173B1 (en) 2017-09-04

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