HK1094769A1 - Pharmaceutical compositions based on idazoxan saltor one of its polymorphs - Google Patents

Pharmaceutical compositions based on idazoxan saltor one of its polymorphs

Info

Publication number
HK1094769A1
HK1094769A1 HK07100684A HK07100684A HK1094769A1 HK 1094769 A1 HK1094769 A1 HK 1094769A1 HK 07100684 A HK07100684 A HK 07100684A HK 07100684 A HK07100684 A HK 07100684A HK 1094769 A1 HK1094769 A1 HK 1094769A1
Authority
HK
Hong Kong
Prior art keywords
idazoxan
pharmaceutical composition
neuroleptic
exhibiting
tablet
Prior art date
Application number
HK07100684A
Inventor
Joel Bougaret
Jean-Louis Avan
Roland Segonds
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of HK1094769A1 publication Critical patent/HK1094769A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A pharmaceutical composition comprises (%) an idazoxan salt or idazoxan hydrate (5-20), microcrystalline cellulose (10-40), lubricant (1-5), colloidal silica (0.1-0.5) and lactose (29.5-84.8). Independent claims are included for the following: (a) tablets comprising the pharmaceutical composition (50 - 1000, preferably 100 - 600) mg; (b) manufacture of the tablet involving direct tabletting of a powder mixture; (c) use of the composition and tablet optionally in combination with an atypical antipsychotic neuroleptic exhibiting a greater antagonist affinity for the dopamine D2 receptor than is its antagonist affinity for the alpha -adrenoreceptor, a medicament for the preventive and/or curative treatment of severe psychotic disorders (preferably schizophrenia and schizoaffective disorders); (d) polymorphic forms I, II, III, IV or V of idazoxan having X-ray diffraction pattern as given in the specification and having a differential thermal analysis thermogram exhibiting a single maximum value at 207.5+-0.2, 203+-0.4, 203.8+-0.5, 205.3+-0.5, 205.6+-0.4 respectively. ACTIVITY : Antidepressant; Antiparkinsonian; Neuroleptic; CNS-Gen.. MECHANISM OF ACTION : None given.
HK07100684A 2003-10-28 2007-01-19 Pharmaceutical compositions based on idazoxan saltor one of its polymorphs HK1094769A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312626A FR2861299B1 (en) 2003-10-28 2003-10-28 PHARMACEUTICAL COMPOSITIONS BASED ON IDASOXAN DERIVATIVES IN POLYMORPHIC FORMS
PCT/FR2004/002773 WO2005041956A1 (en) 2003-10-28 2004-10-28 Pharmaceutical compositions based on idazoxan salt or one of the polymorphs thereof

Publications (1)

Publication Number Publication Date
HK1094769A1 true HK1094769A1 (en) 2007-04-13

Family

ID=34400871

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07100684A HK1094769A1 (en) 2003-10-28 2007-01-19 Pharmaceutical compositions based on idazoxan saltor one of its polymorphs

Country Status (19)

Country Link
US (2) US7338970B2 (en)
EP (1) EP1682124B1 (en)
JP (1) JP5160090B2 (en)
CN (2) CN1870993B (en)
AT (1) ATE381331T1 (en)
AU (1) AU2004285316B2 (en)
BR (1) BRPI0416006B1 (en)
CA (1) CA2542752A1 (en)
CY (1) CY1107304T1 (en)
DE (1) DE602004010837T2 (en)
DK (1) DK1682124T3 (en)
ES (1) ES2297525T3 (en)
FR (1) FR2861299B1 (en)
HK (1) HK1094769A1 (en)
HR (1) HRP20080108T3 (en)
MX (1) MXPA06004717A (en)
PL (1) PL1682124T3 (en)
PT (1) PT1682124E (en)
WO (1) WO2005041956A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8476307B2 (en) * 2003-10-28 2013-07-02 Pierre Fabre Medicament Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
US8088824B2 (en) * 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
WO2023159145A1 (en) * 2022-02-16 2023-08-24 Terran Biosciences, Inc. Deuterated idazoxan and methods of use thereof
CN117338772B (en) * 2023-11-22 2024-04-09 徐州医科大学 Pharmaceutical composition and application thereof in preparation of drugs for preventing and/or treating major depressive disorder

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16249A (en) * 1980-02-04 1983-08-16 Reckitt & Colmann Prod Ltd Imidazoline derivatives,its pharmaceutical composition and method of use
US4541893A (en) * 1984-05-15 1985-09-17 Advanced Micro Devices, Inc. Process for fabricating pedestal interconnections between conductive layers in an integrated circuit
FR2698789B1 (en) 1992-12-07 1995-03-03 Pf Medicament Use of idazoxan and its derivatives for the preparation of a medicament intended for the treatment of Parkinson's disease and its evolution.
US5492907A (en) * 1992-12-09 1996-02-20 The United States Of America As Represented By The Department Of Health & Human Services Antipsychotic composition and method of treatment
IT1264517B1 (en) * 1993-05-31 1996-09-24 Ekita Investments Nv PHARMACEUTICAL TABLET SUITABLE FOR THE RELEASE IN SUBSEQUENT TIMES OF THE ACTIVE PRINCIPLES CARRIED THEREIN
US5574059A (en) * 1995-10-27 1996-11-12 Cornell Research Foundation, Inc. Treating disorders mediated by vascular smooth muscle cell proliferation
FR2746314B1 (en) 1996-03-25 1998-06-12 Pf Medicament PRODUCT CONTAINING MILNACIPRAN AND IDAZOXAN AS A COMBINED PHARMACEUTICAL PREPARATION
US6232215B1 (en) * 1996-09-18 2001-05-15 United Microelectronics Corp. Method for forming increased density for interconnection metallization
FR2774811B1 (en) * 1998-02-10 2003-05-09 Sgs Thomson Microelectronics CONDUCTIVE LINES FORMATION PROCESS ON INTEGRATED CIRCUITS
FR2801786B1 (en) * 1999-12-01 2002-03-01 Fabre Pierre Cosmetique NOVEL TOPICAL COMPOSITIONS BASED ON IDAZOXAN AND CAFFEINE OR ITS SOLUBLE DERIVATIVES AND THEIR USE AS SLIMMERS AND / OR IN THE TREATMENT OF CELLULITE

Also Published As

Publication number Publication date
CN102349873A (en) 2012-02-15
DE602004010837D1 (en) 2008-01-31
CN102349873B (en) 2013-09-25
EP1682124A1 (en) 2006-07-26
WO2005041956A1 (en) 2005-05-12
US8124640B2 (en) 2012-02-28
US20080113022A1 (en) 2008-05-15
ATE381331T1 (en) 2008-01-15
US7338970B2 (en) 2008-03-04
CA2542752A1 (en) 2005-05-12
ES2297525T3 (en) 2008-05-01
HRP20080108T3 (en) 2008-04-30
DK1682124T3 (en) 2008-04-28
DE602004010837T2 (en) 2008-12-11
CY1107304T1 (en) 2012-11-21
FR2861299A1 (en) 2005-04-29
JP5160090B2 (en) 2013-03-13
FR2861299B1 (en) 2006-01-27
AU2004285316B2 (en) 2010-08-19
PL1682124T3 (en) 2008-05-30
MXPA06004717A (en) 2006-07-05
PT1682124E (en) 2008-03-05
CN1870993B (en) 2012-04-04
US20050090537A1 (en) 2005-04-28
AU2004285316A1 (en) 2005-05-12
JP2007509911A (en) 2007-04-19
EP1682124B1 (en) 2007-12-19
CN1870993A (en) 2006-11-29
BRPI0416006B1 (en) 2019-02-05
BRPI0416006A (en) 2007-01-02

Similar Documents

Publication Publication Date Title
AU2015213778B2 (en) Pharmaceutical compositions comprising an antipsychotic drug and a VMAT2 inhibitor and uses thereof
O'Donnell et al. Fluoroquinolones
Keck et al. Clinical pharmacodynamics and pharmacokinetics of antimanic and mood-stabilizing medications
EP1858515A2 (en) Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
HRP20080108T3 (en) Pharmaceutical compositions based on idazoxan salt or one of its polymorphs
US20050233010A1 (en) Lithium combinations, and uses related thereto
ZA200500887B (en) Use of and some novel imidazopyridines.
RS52577B (en) Once-a-day oxycodone formulations
CA2332408A1 (en) Combination therapy for treatment of bipolar disorders
UA102517C2 (en) Substituted morpholine and thiomorpholine derivatives, pharmaceutical composition based thereon and use thereof for the preparation of medicament for the treatment of a disorder or disease of the central nervous system
ES2193875A1 (en) Benzoxazinone derivatives, the preparation and use thereof as medicaments
RU2007132852A (en) COMBINATION PRODUCT OF O-DESMETHYLENENLAXIN AND BASEDOXIFEN AND ITS APPLICATION
PE20061318A1 (en) NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS
JP6406713B2 (en) Treatment of depression and other diseases with low dose drugs
HRP20090569T1 (en) Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using them
MXPA03000548A (en) New combination of serotonin agonist (5ht2) and antagonist (5ht6)as pharmaceutical formulation.
CA2507002A1 (en) Solid drug for oral use
US20220096444A1 (en) Prophylactic or therapeutic agent for delirium
JP2007516193A5 (en)
EP1784173A4 (en) Pharmaceutical composition for preventing and treating metabolic bone diseases containing alpha-arylmethoxyacrylate derivatives
AU4062900A (en) Methods and compositions for the treatment of neuroleptic and related disorders using ziprasidone metabolites
Bhanji et al. Persistent tardive rebound panic disorder, rebound anxiety and insomnia following paroxetine withdrawal: a review of rebound-withdrawal phenomena
GEP20074225B (en) Use of carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders
Müller-Spahn Current use of atypical antipsychotics
Spina et al. Newer antipsychotics: comparative review of drug interactions

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191026