HK1052198A1 - Metabollically engineered cells overexpressing pyruvate carboxylase or pyruvate phosphoenolpyruvate carbokylase, and methods to produce and use such cells - Google Patents

Metabollically engineered cells overexpressing pyruvate carboxylase or pyruvate phosphoenolpyruvate carbokylase, and methods to produce and use such cells

Info

Publication number
HK1052198A1
HK1052198A1 HK03101556.1A HK03101556A HK1052198A1 HK 1052198 A1 HK1052198 A1 HK 1052198A1 HK 03101556 A HK03101556 A HK 03101556A HK 1052198 A1 HK1052198 A1 HK 1052198A1
Authority
HK
Hong Kong
Prior art keywords
pyruvate
cells
metabollically
carbokylase
phosphoenolpyruvate
Prior art date
Application number
HK03101556.1A
Other languages
Chinese (zh)
Inventor
A Eiteman Mark
Altman Elliot
R Gokarn Ravi
Original Assignee
The Univ Of Georgia Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Univ Of Georgia Research Foundation Inc filed Critical The Univ Of Georgia Research Foundation Inc
Publication of HK1052198A1 publication Critical patent/HK1052198A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
HK03101556.1A 1999-10-13 2003-03-03 Metabollically engineered cells overexpressing pyruvate carboxylase or pyruvate phosphoenolpyruvate carbokylase, and methods to produce and use such cells HK1052198A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15946799P 1999-10-13 1999-10-13
PCT/US2000/028578 WO2001027258A2 (en) 1999-10-13 2000-10-13 High yield protein expression system and methods

Publications (1)

Publication Number Publication Date
HK1052198A1 true HK1052198A1 (en) 2003-09-05

Family

ID=22572721

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101556.1A HK1052198A1 (en) 1999-10-13 2003-03-03 Metabollically engineered cells overexpressing pyruvate carboxylase or pyruvate phosphoenolpyruvate carbokylase, and methods to produce and use such cells

Country Status (9)

Country Link
EP (1) EP1235903A2 (en)
JP (1) JP2003511067A (en)
AR (1) AR026892A1 (en)
AU (1) AU1206801A (en)
BR (1) BR0014758A (en)
CA (1) CA2387605A1 (en)
HK (1) HK1052198A1 (en)
MX (1) MXPA02003634A (en)
WO (1) WO2001027258A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368266B2 (en) 2001-02-13 2008-05-06 Cj Corporation Method for L-threonine production
KR100397423B1 (en) 2001-02-13 2003-09-13 씨제이 주식회사 Process for producing L-threonine
US8119365B2 (en) 2002-01-23 2012-02-21 Wisconsin Alumni Research Foundation Insertion sequence-free bacteria
US8765408B2 (en) 2002-01-23 2014-07-01 Wisconsin Alumni Research Foundation Prophage element-free bacteria
US8039243B2 (en) 2002-01-23 2011-10-18 Wisconsin Alumni Research Foundation Insertion sequence-free bacteria
US6989265B2 (en) 2002-01-23 2006-01-24 Wisconsin Alumni Research Foundation Bacteria with reduced genome
DE10219714A1 (en) * 2002-05-02 2003-11-27 Holland Sweetener Co Process for the microbial production of aromatic amino acids and other metabolites of the aromatic amino acid biosynthetic pathway
US7303906B2 (en) 2002-09-06 2007-12-04 Wisconsin Alumni Research Foundation Competent bacteria
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
KR101183720B1 (en) 2004-01-16 2012-09-17 다우 글로벌 테크놀로지스 엘엘씨 Expression of mammalian proteins in pseudomonas fluorescens
WO2005087940A1 (en) * 2004-03-11 2005-09-22 Wisconsin Alumni Research Foundation Genetically altered microorganisms with modified metabolism
EP1584680A1 (en) * 2004-04-08 2005-10-12 Boehringer Ingelheim Austria GmbH Fed-batch fermentation process for the production of plasmid DNA
JP4720114B2 (en) * 2004-05-20 2011-07-13 三菱化学株式会社 Method for producing oxaloacetic acid or oxaloacetic acid derivative
JP2008507294A (en) 2004-07-26 2008-03-13 ダウ グローバル テクノロジーズ インコーポレイティド Method for improved protein expression by strain genetic manipulation
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
AU2008245696B2 (en) 2007-04-27 2013-11-07 Pelican Technology Holdings, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2692911B1 (en) 2011-03-31 2017-02-22 Kunimine Industries Co., Ltd. Use of agent for searching for protein crystallization conditions, and method for searching for protein crystallization conditions
JP2015156844A (en) * 2014-02-25 2015-09-03 花王株式会社 Bacillus subtilis variant and method for producing of dipicolinic acid using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006114A1 (en) * 1993-08-24 1995-03-02 Ajinomoto Co., Inc. Variant phosphoenolpyruvate carboxylase, gene thereof, and process for producing amino acid
EP2194122B1 (en) * 1998-04-13 2015-12-02 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
DE19904794A1 (en) * 1999-02-05 2000-08-10 Biotechnolog Forschung Gmbh Methods for improving the primary metabolism of mammalian cell lines

Also Published As

Publication number Publication date
WO2001027258A2 (en) 2001-04-19
MXPA02003634A (en) 2002-10-23
BR0014758A (en) 2002-07-02
CA2387605A1 (en) 2001-04-19
WO2001027258A3 (en) 2001-12-27
JP2003511067A (en) 2003-03-25
EP1235903A2 (en) 2002-09-04
AR026892A1 (en) 2003-03-05
AU1206801A (en) 2001-04-23

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