HK1046915A1 - 人類肝細胞生長因子受體酪氨酸激酶催化結構域及鑒定其抑制劑的方法 - Google Patents

人類肝細胞生長因子受體酪氨酸激酶催化結構域及鑒定其抑制劑的方法

Info

Publication number
HK1046915A1
HK1046915A1 HK02108247.2A HK02108247A HK1046915A1 HK 1046915 A1 HK1046915 A1 HK 1046915A1 HK 02108247 A HK02108247 A HK 02108247A HK 1046915 A1 HK1046915 A1 HK 1046915A1
Authority
HK
Hong Kong
Prior art keywords
inhibitors
identification
methods
growth factor
tyrosine kinase
Prior art date
Application number
HK02108247.2A
Other languages
English (en)
Inventor
Mroczkowski Barbara
Hickey Michael
Ann Mctigue Michele
William Murray Brion
Parge Hans
Sarup Jay
Zhu Jeff
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of HK1046915A1 publication Critical patent/HK1046915A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK02108247.2A 2001-03-23 2002-11-14 人類肝細胞生長因子受體酪氨酸激酶催化結構域及鑒定其抑制劑的方法 HK1046915A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27796801P 2001-03-23 2001-03-23

Publications (1)

Publication Number Publication Date
HK1046915A1 true HK1046915A1 (zh) 2003-01-30

Family

ID=23063133

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02108247.2A HK1046915A1 (zh) 2001-03-23 2002-11-14 人類肝細胞生長因子受體酪氨酸激酶催化結構域及鑒定其抑制劑的方法

Country Status (6)

Country Link
US (1) US20040009568A1 (zh)
EP (1) EP1243596A3 (zh)
JP (1) JP2003009887A (zh)
AU (1) AU2760602A (zh)
CA (1) CA2378494A1 (zh)
HK (1) HK1046915A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7678769B2 (en) 2001-09-14 2010-03-16 Compugen, Ltd. Hepatocyte growth factor receptor splice variants and methods of using same
CA2503736A1 (en) * 2002-11-26 2004-06-10 Cold Spring Harbor Laboratory Dep-1 receptor protein tyrosine phosphatase interacting proteins and related methods
WO2004092217A1 (en) * 2003-04-17 2004-10-28 Pfizer Inc. Crystal structure of vegfrkd: ligand complexes and methods of use thereof
EP1627323A4 (en) * 2003-05-06 2008-04-09 New Century Pharmaceuticals ALBUMIN FIXATION SITES FOR EVALUATING DRUG INTERACTIONS OR THE DEVELOPMENT OF MEDICAMENTS BASED ON THEIR ALBUMIN BINDING PROPERTIES
US20070043509A1 (en) * 2003-11-03 2007-02-22 Carter Daniel C Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties
US7872117B2 (en) * 2004-03-26 2011-01-18 Van Andel Research Institute c-met siRNA adenovirus vectors inhibit cancer cell growth, invasion and tumorigenicity
WO2005108424A1 (en) * 2004-05-06 2005-11-17 Genentech, Inc. Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use
US7758862B2 (en) 2005-09-30 2010-07-20 Compugen Ltd. Hepatocyte growth factor receptor splice variants and methods of using same
US7960134B1 (en) 2007-08-01 2011-06-14 Arqule, Inc. Kinase inhibition models and their uses
IL198545A0 (en) 2008-05-14 2011-07-31 Metheresis Translational Res Sa High affinity binding site of hgfr and methods for identification of antagonists thereof
WO2012092302A1 (en) * 2010-12-27 2012-07-05 Expression Pathology, Inc. Cmet protein srm/mrm assay

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2104914T3 (es) * 1991-05-10 1997-10-16 Pharmacia & Upjohn Spa Formas truncadas del factor de crecimiento de hepatocitos (hgf).

Also Published As

Publication number Publication date
AU2760602A (en) 2002-09-26
JP2003009887A (ja) 2003-01-14
EP1243596A3 (en) 2003-02-12
US20040009568A1 (en) 2004-01-15
EP1243596A2 (en) 2002-09-25
CA2378494A1 (en) 2002-09-23

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