HK1025954A1 - Triptolide derivatives useful in the treatment of autoimmune diseases - Google Patents

Triptolide derivatives useful in the treatment of autoimmune diseases

Info

Publication number
HK1025954A1
HK1025954A1 HK00105090A HK00105090A HK1025954A1 HK 1025954 A1 HK1025954 A1 HK 1025954A1 HK 00105090 A HK00105090 A HK 00105090A HK 00105090 A HK00105090 A HK 00105090A HK 1025954 A1 HK1025954 A1 HK 1025954A1
Authority
HK
Hong Kong
Prior art keywords
treatment
autoimmune diseases
derivatives useful
triptolide derivatives
triptolide
Prior art date
Application number
HK00105090A
Other languages
English (en)
Inventor
Michel J Jung
Mahinda Wickramaratne
Michael Hepperle
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of HK1025954A1 publication Critical patent/HK1025954A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK00105090A 1997-05-23 2000-08-15 Triptolide derivatives useful in the treatment of autoimmune diseases HK1025954A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86248997A 1997-05-23 1997-05-23
PCT/US1998/008562 WO1998052933A1 (en) 1997-05-23 1998-04-27 Novel triptolide derivatives useful in the treatment of autoimmune diseases

Publications (1)

Publication Number Publication Date
HK1025954A1 true HK1025954A1 (en) 2000-12-01

Family

ID=25338618

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00105090A HK1025954A1 (en) 1997-05-23 2000-08-15 Triptolide derivatives useful in the treatment of autoimmune diseases

Country Status (18)

Country Link
EP (1) EP0983256B1 (xx)
JP (1) JP2002500647A (xx)
KR (1) KR20010012820A (xx)
AR (1) AR012737A1 (xx)
AT (1) ATE261434T1 (xx)
AU (1) AU741209B2 (xx)
BR (1) BR9809673A (xx)
CA (1) CA2288327A1 (xx)
DE (1) DE69822297T2 (xx)
ES (1) ES2213279T3 (xx)
HK (1) HK1025954A1 (xx)
HU (1) HUP0003244A3 (xx)
IL (1) IL133089A0 (xx)
NO (1) NO995722L (xx)
NZ (1) NZ500699A (xx)
TW (1) TW462966B (xx)
WO (1) WO1998052933A1 (xx)
ZA (1) ZA984177B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2448795A1 (en) * 2001-03-15 2002-09-26 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agent
EP2468277A1 (en) 2002-05-31 2012-06-27 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
US7820834B2 (en) 2003-12-24 2010-10-26 Pharmagenesis, Inc. Triptolide 5,6-derivatives as immunomodulators and anticancer agents
CN1917893A (zh) 2004-02-09 2007-02-21 美国泛华医药公司 从雷公藤多苷中分离雷公藤内酯醇化合物的方法
EP1732536B1 (en) 2004-03-02 2012-04-25 Pharmagenesis, Inc. Triptolide lactone ring derivatives as immunomodulators and anticancer agents
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006044496A2 (en) 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
US20120020954A1 (en) 2009-03-30 2012-01-26 Anat Achiron Methods of predicting clinical course and treating multiple sclerosis
WO2012123938A1 (en) 2011-03-17 2012-09-20 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
EP3074391B1 (en) 2013-11-28 2019-07-31 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
CN113768939A (zh) * 2021-09-30 2021-12-10 深圳艾克斯恩生物科技有限公司 雷公藤二醇在制备预防和/或治疗nlrp3炎症小体介导的炎症性疾病药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026265A1 (en) * 1993-05-06 1994-11-24 Pharmagenesis, Inc. 16-hydroxytriptolide composition and method for immunotherapy
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
NZ500699A (en) 2001-08-31
ZA984177B (en) 1998-11-23
WO1998052933A1 (en) 1998-11-26
ES2213279T3 (es) 2004-08-16
NO995722L (no) 2000-01-21
TW462966B (en) 2001-11-11
DE69822297T2 (de) 2004-07-29
DE69822297D1 (de) 2004-04-15
BR9809673A (pt) 2000-07-11
EP0983256A1 (en) 2000-03-08
IL133089A0 (en) 2001-03-19
HUP0003244A3 (en) 2001-09-28
HUP0003244A2 (en) 2001-03-28
AR012737A1 (es) 2000-11-08
AU7363498A (en) 1998-12-11
KR20010012820A (ko) 2001-02-26
JP2002500647A (ja) 2002-01-08
ATE261434T1 (de) 2004-03-15
CA2288327A1 (en) 1998-11-26
AU741209B2 (en) 2001-11-22
EP0983256B1 (en) 2004-03-10
NO995722D0 (no) 1999-11-22

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120427