GT200400133AA - PIRROLO DERIVATIVES [3,4-C] PIRAZOL, ASSETS AS QUINASE INHIBITORS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM. (FRACTIONARY APPLICATION NO. 1, DERIVED FROM THE PATENT NO. PI-2004-0133). - Google Patents

PIRROLO DERIVATIVES [3,4-C] PIRAZOL, ASSETS AS QUINASE INHIBITORS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM. (FRACTIONARY APPLICATION NO. 1, DERIVED FROM THE PATENT NO. PI-2004-0133).

Info

Publication number
GT200400133AA
GT200400133AA GT200400133AK GT200400133K GT200400133AA GT 200400133A A GT200400133A A GT 200400133AA GT 200400133A K GT200400133A K GT 200400133AK GT 200400133 K GT200400133 K GT 200400133K GT 200400133A A GT200400133A A GT 200400133AA
Authority
GT
Guatemala
Prior art keywords
fractionary
pirazol
assets
understand
derived
Prior art date
Application number
GT200400133AK
Other languages
Spanish (es)
Inventor
Daniele Fancelli
Barbara Forte
Juergen Moll
Mario Varasi
Paola Vianello
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200400133AA publication Critical patent/GT200400133AA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL I EN LA QUE R,X,R1,R2, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON INHIBIDORES DE QUINASA POR LO QUE SON DE UTILIDAD EN PATOLOGIAS DE HIPERPROLIFERACION CELULAR TALES COMO EL CANCER.THE PRESENT INVENTION REFERS TO COMPOUNDS OF GENERAL FORMULA I IN WHICH R, X, R1, R2, ARE FUNCTIONAL GROUPS DESCRIBED IN THE RECORD. THESE COMPOUNDS ARE QUINASE INHIBITORS FOR WHICH THEY ARE USEFUL IN CELLULAR HYPERPROLIFERATION PATHOLOGIES SUCH AS CANCER.

GT200400133AK 2003-07-09 2004-07-09 PIRROLO DERIVATIVES [3,4-C] PIRAZOL, ASSETS AS QUINASE INHIBITORS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM. (FRACTIONARY APPLICATION NO. 1, DERIVED FROM THE PATENT NO. PI-2004-0133). GT200400133AA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48581403P 2003-07-09 2003-07-09

Publications (1)

Publication Number Publication Date
GT200400133AA true GT200400133AA (en) 2007-07-10

Family

ID=34062099

Family Applications (2)

Application Number Title Priority Date Filing Date
GT200400133AK GT200400133AA (en) 2003-07-09 2004-07-09 PIRROLO DERIVATIVES [3,4-C] PIRAZOL, ASSETS AS QUINASE INHIBITORS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM. (FRACTIONARY APPLICATION NO. 1, DERIVED FROM THE PATENT NO. PI-2004-0133).
GT200400133A GT200400133A (en) 2003-07-09 2004-07-09 PIRROLO DERIVATIVES [3,4-C] PIRAZOL ASSETS AS QUINASE INHIBITORS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM

Family Applications After (1)

Application Number Title Priority Date Filing Date
GT200400133A GT200400133A (en) 2003-07-09 2004-07-09 PIRROLO DERIVATIVES [3,4-C] PIRAZOL ASSETS AS QUINASE INHIBITORS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM

Country Status (42)

Country Link
US (2) US7141568B2 (en)
EP (1) EP1644376B1 (en)
JP (1) JP4728232B2 (en)
KR (1) KR101075711B1 (en)
CN (1) CN100564380C (en)
AP (1) AP2214A (en)
AR (1) AR050045A1 (en)
AT (1) ATE480540T1 (en)
AU (1) AU2004255347B2 (en)
BR (1) BRPI0411868B8 (en)
CA (1) CA2531759C (en)
CR (1) CR8171A (en)
CY (1) CY1110832T1 (en)
DE (1) DE602004029045D1 (en)
DK (1) DK1644376T3 (en)
DO (1) DOP2004000949A (en)
EA (1) EA009462B1 (en)
EC (1) ECSP056246A (en)
ES (1) ES2349780T3 (en)
GE (1) GEP20084395B (en)
GT (2) GT200400133AA (en)
HK (1) HK1089769A1 (en)
HN (1) HN2004000232A (en)
IL (1) IL172923A (en)
IS (1) IS2843B (en)
MA (1) MA28064A1 (en)
ME (1) MEP51908A (en)
MX (1) MXPA06000362A (en)
MY (1) MY139072A (en)
NO (1) NO332361B1 (en)
NZ (1) NZ544514A (en)
PA (1) PA8606201A1 (en)
PE (1) PE20050325A1 (en)
PL (1) PL1644376T3 (en)
PT (1) PT1644376E (en)
RS (2) RS20060004A (en)
SI (1) SI1644376T1 (en)
TN (1) TNSN06009A1 (en)
TW (1) TWI343382B (en)
UA (1) UA81682C2 (en)
WO (1) WO2005005427A1 (en)
ZA (1) ZA200600095B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60143041D1 (en) * 2000-08-10 2010-10-21 Pfizer Italia Srl Bicyclic pyrazoles are effective as kinase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
AU2004276341B2 (en) * 2003-09-23 2011-04-14 Vertex Pharmaceuticals Incorporated Pyrazolopyrrole derivatives as protein kinase inhibitors
JP2007514759A (en) * 2003-12-19 2007-06-07 タケダ サン ディエゴ インコーポレイテッド Kinase inhibitor
WO2005105788A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
WO2006023931A2 (en) * 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
US7713973B2 (en) 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
ES2365245T3 (en) * 2005-01-10 2011-09-27 Pfizer, Inc. PIRROLOPIRAZOLES, POWERFUL INHIBITORS OF QUINASAS.
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
TW200808311A (en) 2006-03-30 2008-02-16 Nerviano Medical Sciences Srl Use of a kinase inhibitor for the treatment of particular resistant tumors
WO2008017465A1 (en) * 2006-08-10 2008-02-14 F. Hoffmann-La Roche Ag Bicyclic lactam derivatives, their manufacture and use as pharmaceutical agents
GEP20135728B (en) 2006-10-09 2013-01-25 Takeda Pharmaceuticals Co Kinase inhibitors
JP2010505961A (en) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド Kinase inhibitor
BRPI0717998A2 (en) * 2006-11-03 2013-12-03 Nerviano Medical Sciences Srl METHOD FOR ADMINISTERING AN ANTITUMOR COMPOUND.
CL2009001158A1 (en) * 2008-05-15 2009-10-23 Nerviano Medical Sciences Srl Compounds derived from carboxylic acids, such as 5,6-dihiro-4h-pyrrolo [3,4-c] pyrazole, furo [3,2-c] pyrazole, thieno [2,3-c] pyrazole, 4,5 , 6,7-tetrahydropyrazole [4,3-c] pyridine and indazole; pharmaceutical composition; and its use in the treatment of cell proliferative disorders associated with altered protein kinase activity, such as cancer.
US20100022553A1 (en) * 2008-07-24 2010-01-28 Nerviano Medical Sciences S.R.L. Therapeutic Combination Comprising an Aurora Kinase Inhibitor and Imatinib
CN102105148B (en) * 2008-07-24 2013-04-10 内尔维阿诺医学科学有限公司 Therapeutic combination comprising an AURORA kinase inhibitor and antiproliferative agents
JP5518062B2 (en) * 2008-07-24 2014-06-11 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ A therapeutic combination comprising an aurora kinase inhibitor and an antineoplastic agent
KR101741168B1 (en) 2008-12-22 2017-05-29 밀레니엄 파머슈티컬스 인코퍼레이티드 Combination of aurora kinase inhibitors and anti-cd20 antibodies
MX356401B (en) 2011-12-12 2018-05-21 Dr Reddys Laboratories Ltd Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (trk) inhibitors.
CN104072498B (en) * 2013-03-26 2016-12-28 沈阳药科大学 (R) synthetic method of N [5 (2 methoxyl group 2 phenyl acetyl) 1,4,5,6 nafoxidines also [3,4 c] pyrazoles 3 base] 4 (4 methyl piperazine 1 base) Benzoylamide
JP6525474B2 (en) 2013-12-06 2019-06-05 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Combination of Aurora kinase inhibitor and anti-CD30 antibody
EP3157921A1 (en) 2014-06-23 2017-04-26 Dr. Reddy's Laboratories Ltd. Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain
KR102588426B1 (en) * 2015-06-15 2023-10-13 유비이 가부시키가이샤 Substituted dihydropyrrolopyrazole derivatives
CN107337674B (en) * 2016-04-29 2019-09-20 江苏吉贝尔药业股份有限公司 For the oxinane amine derivative of DPP-IV inhibitor, its pharmaceutical composition and preparation and purposes
US11874276B2 (en) 2018-04-05 2024-01-16 Dana-Farber Cancer Institute, Inc. STING levels as a biomarker for cancer immunotherapy
US20220305048A1 (en) 2019-08-26 2022-09-29 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling
CN113563346A (en) * 2021-08-19 2021-10-29 守恒(厦门)医疗科技有限公司 Pyrrole [3,4-c ] pyrazole diamide derivatives and application thereof in antitumor drugs
WO2023196959A1 (en) 2022-04-07 2023-10-12 Eli Lilly And Company Process for making a kras g12c inhibitor
WO2023196887A1 (en) 2022-04-08 2023-10-12 Eli Lilly And Company Method of treatment including kras g12c inhibitors and aurora a inhibitors
US20240108618A1 (en) 2022-06-30 2024-04-04 Eli Lilly And Company Kras g12c inhibitor dosing regimens

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717380B1 (en) * 1994-03-15 1996-04-26 Oreal Cosmetic compositions containing a synergistic blend of conditioning polymers.
GB9911053D0 (en) 1999-05-12 1999-07-14 Pharmacia & Upjohn Spa 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
DE19932144A1 (en) * 1999-07-09 2001-01-11 Basf Ag Microcapsule preparations and washing and cleaning agents containing microcapsules
US6387900B1 (en) 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
SK1812002A3 (en) 1999-08-12 2003-02-04 Pharmacia Italia Spa 3(5)-Amino-pyrazole derivatives, process for their preparation and their use as antitumor agents
DE60143041D1 (en) 2000-08-10 2010-10-21 Pfizer Italia Srl Bicyclic pyrazoles are effective as kinase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
FR2815032B1 (en) 2000-10-10 2003-08-08 Pf Medicament NOVEL AMINOPHENYL PIPERAZINE OR AMINO PHENYL PIPERIDE DERIVATIVES PRENYL TRANSFERASE PROTEIN INHIBITORS AND PREPARATIONS THEREOF
MXPA03004644A (en) 2000-11-27 2003-09-05 Pharmacia Italia Spa Phenylacetamido- pyrazole derivatives and their use as antitumor agents.
MXPA03006478A (en) 2001-01-26 2003-09-22 Pharmacia Italia Spa Chromane derivatives, process for their preparation and their use as antitumor agents.
ES2380054T3 (en) 2001-09-26 2012-05-08 Pfizer Italia S.R.L. Active aminoindazole derivatives such as kinase inhibitors, preparation procedures, and pharmaceutical compositions containing them
BR0312924A (en) 2002-07-25 2005-07-12 Pharmacia Italia Spa Active bicyclo-pyrazoles as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
ES2349780T3 (en) 2011-01-11
US7582628B2 (en) 2009-09-01
EA009462B1 (en) 2007-12-28
KR101075711B1 (en) 2011-10-21
EP1644376A1 (en) 2006-04-12
IS8192A (en) 2005-12-22
AP2006003480A0 (en) 2006-02-28
DK1644376T3 (en) 2011-01-03
CN100564380C (en) 2009-12-02
TNSN06009A1 (en) 2007-10-03
DOP2004000949A (en) 2005-01-15
AP2214A (en) 2011-03-04
MEP51908A (en) 2011-05-10
CY1110832T1 (en) 2015-06-10
ECSP056246A (en) 2006-04-19
JP4728232B2 (en) 2011-07-20
PE20050325A1 (en) 2005-05-17
MA28064A1 (en) 2006-08-01
WO2005005427A1 (en) 2005-01-20
ATE480540T1 (en) 2010-09-15
CR8171A (en) 2006-08-09
DE602004029045D1 (en) 2010-10-21
IS2843B (en) 2013-08-15
BRPI0411868B1 (en) 2019-11-12
PL1644376T3 (en) 2011-03-31
AR050045A1 (en) 2006-09-27
RS20060004A (en) 2008-06-05
SI1644376T1 (en) 2010-11-30
IL172923A0 (en) 2006-06-11
PA8606201A1 (en) 2005-08-04
RS52155B (en) 2012-08-31
PT1644376E (en) 2010-09-24
EA200600209A1 (en) 2006-06-30
US7141568B2 (en) 2006-11-28
HN2004000232A (en) 2011-01-17
TW200510385A (en) 2005-03-16
EP1644376B1 (en) 2010-09-08
JP2009513525A (en) 2009-04-02
BRPI0411868A (en) 2006-08-08
CN1820009A (en) 2006-08-16
US20060276471A1 (en) 2006-12-07
NZ544514A (en) 2009-07-31
MXPA06000362A (en) 2006-03-28
KR20060033001A (en) 2006-04-18
GT200400133A (en) 2005-04-18
CA2531759A1 (en) 2005-01-20
UA81682C2 (en) 2008-01-25
HK1089769A1 (en) 2006-12-08
CA2531759C (en) 2013-04-02
AU2004255347A1 (en) 2005-01-20
BRPI0411868B8 (en) 2021-05-25
MY139072A (en) 2009-08-28
AU2004255347B2 (en) 2010-04-08
GEP20084395B (en) 2008-06-10
NO20060113L (en) 2006-04-05
TWI343382B (en) 2011-06-11
NO332361B1 (en) 2012-09-03
US20050032839A1 (en) 2005-02-10
IL172923A (en) 2011-09-27
ZA200600095B (en) 2007-01-31

Similar Documents

Publication Publication Date Title
GT200400133AA (en) PIRROLO DERIVATIVES [3,4-C] PIRAZOL, ASSETS AS QUINASE INHIBITORS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM. (FRACTIONARY APPLICATION NO. 1, DERIVED FROM THE PATENT NO. PI-2004-0133).
AR053412A1 (en) INHIBITING COMPOUNDS OF INTERACTION BETWEEN MDM2 AND P53, A METHOD OF PREPARATION, PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOUND TO MANUFACTURE MEDICATIONS
GT200500103A (en) 4-PHENYLAMINE-QUINAZOLIN-6-IL-AMIDAS
GT200500008A (en) QUINOLINE INTERMEDIARIES AS INHIBITORS OF THIROSINE KINASE RECEPTORS AND THE SYNTHESIS OF THE SAME
ECSP056127A (en) FOSFATIDIL-INOSITOL 3-KINASE INHIBITORS
BRPI0418031A (en) phosphonate-substituted kinase inhibitors
GT200300292A (en) PIRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH
BRPI0607455A2 (en) compound, process for preparing same, use of a compound, and pharmaceutical composition
UY28679A1 (en) NEW ORGANOPHOSPHORATED DERIVATIVES OF INDAZOLS AND USE AS MEDICATIONS.
ATE433447T1 (en) PYRIMIIDINE COMPOUNDS
GT200300005A (en) 2- (PIRIDIN-2-ILAMINO) -PIRIDO [2,3-D] PIRIMIDIN-7-ONAS
UY28745A1 (en) NEW COMPOUNDS
GT200300087A (en) 2- (2,6-DICLOROPHENYL) -DIARYLIMIDAZOLS
GT200300129A (en) DERIVATIVES OF HETEROARILAMIDA BENZO CONDENSED OF USEFUL TIENOPIRIDINS AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THE SAME AND METHOD FOR USE
ECSP066667A (en) SPIROCICLIC CYCLHEXAN DERIVATIVES
UY30220A1 (en) TETRAHYDROPIRIDOTIENOPIRIMIDINA COMPOUNDS AND METHODS FOR USE
GT200600144AA (en) 1H-QUINAZOLIN-2,4-DIONAS (FRACTIONARY APPLICATION, DERIVED FROM THE INVENTION PATENT APPLICATION PI-2006-00144)
GT200700036A (en) CONDENSED HETEROCICLIC FENIL AMIDO COMPOUNDS
BRPI0512683A (en) antiviral compounds
PA8593001A1 (en) PIRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH
CL2011001967A1 (en) Compounds derived from substituted carboxamide-azaheterocyclic, p70s6k inhibitors, preparation process thereof; pharmaceutical composition that includes them; and its use in the treatment of inflammatory diseases and cancer; Pharmaceutical kit
UY29767A1 (en) BENZOTIAZOLONAS DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND APPLICATIONS
DOP2006000061A (en) PIRIMIDINE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS
GB0525673D0 (en) Organic compounds
GT200600161A (en) NEW THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS