GT200300189A - HETEROCICLIC DERIVATIVES - Google Patents

HETEROCICLIC DERIVATIVES

Info

Publication number
GT200300189A
GT200300189A GT200300189A GT200300189A GT200300189A GT 200300189 A GT200300189 A GT 200300189A GT 200300189 A GT200300189 A GT 200300189A GT 200300189 A GT200300189 A GT 200300189A GT 200300189 A GT200300189 A GT 200300189A
Authority
GT
Guatemala
Prior art keywords
pulmonicularity
compounds
syrdrome
elastasa
enh
Prior art date
Application number
GT200300189A
Other languages
Spanish (es)
Inventor
Heike Gielen
Volkhart Li
Ulrich Rosentreter
Karl Heinz Schlemmer
Swen Allerheiligen
Leila Telan
Lars Barfacker
Joerg Keldenich
Mary F Fitzgerald
Kevin Nash
Barbara Albrecht
Dirk Meurer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200300189A publication Critical patent/GT200300189A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL I EN LA QUE Y1,Y2,Y3,Y4,Y5,R1,R2,R3,R4,R5,R6,R7, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS INHIBEN LA ACTIVIDAD DE LA ELASTASA NEUTROFILICA HUMANA (ENH) POR LO QUE SON DE UTILIDAD PRINCIPALMENTE EN CUADROS INFLAMATORIOS, PRINCIPALMENTE EN LA REGION PULMONAR COMO SINDROME DE DIFICULTAD RESPIRATORIA, ENFISEMA PULMONAR, INCLUYENDO EL INDUCIDO POR TABAQUISMO, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, PERO TAMBIEN EN CASOS DE INFARTO AGUDO DE MIOCARDIO, DESARROLLO DE INSUFICIENCIA CARDIACA.THE PRESENT INVENTION REFERS TO COMPOUNDS OF GENERAL FORMULA I IN WHICH Y1, Y2, Y3, Y4, Y5, R1, R2, R3, R4, R5, R6, R7, ARE FUNCTIONAL GROUPS DESCRIBED IN THE RECORD. THESE COMPOUNDS INHIBIT THE ACTIVITY OF THE HUMAN NEUTROPHILIC ELASTASA (ENH), SO THAT THEY ARE USEFULLY USED IN INFLAMMATORY TABLES, MAINLY IN THE PULMONARY REGION AS A SYRDROME DISTRIBUTION, SYMPTOMS, PULMONICULARITY, PULMONICULARITY, PULMONICULARITY, OCCUPATIONAL DISABILITY, INCLUDES PULMONICULARITY Also in cases of acute myocardial infarction, development of cardiac insufficiency.

GT200300189A 2002-09-10 2003-09-04 HETEROCICLIC DERIVATIVES GT200300189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0220962A GB0220962D0 (en) 2002-09-10 2002-09-10 Heterocyclic derivatives

Publications (1)

Publication Number Publication Date
GT200300189A true GT200300189A (en) 2004-04-19

Family

ID=9943787

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200300189A GT200300189A (en) 2002-09-10 2003-09-04 HETEROCICLIC DERIVATIVES

Country Status (4)

Country Link
CN (1) CN100575346C (en)
GB (2) GB0220962D0 (en)
GT (1) GT200300189A (en)
ZA (1) ZA200501964B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9073939B2 (en) * 2009-07-10 2015-07-07 Bayer Intellectual Property Gmbh Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof
CN107635972A (en) * 2015-03-18 2018-01-26 拜耳制药股份公司 Method for producing the formonitrile HCN of 2 oxo 1 [3 (trifluoromethyl) phenyl] 1,2,3,4 tetrahydropyrimidine of (4S) 4 [4 cyano group 2 (methyl sulphonyl) phenyl] 3,6 dimethyl 5

Also Published As

Publication number Publication date
GB0220962D0 (en) 2002-10-23
GB0226609D0 (en) 2002-12-24
CN100575346C (en) 2009-12-30
CN1732159A (en) 2006-02-08
ZA200501964B (en) 2006-05-31

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