GT200200252A - 1,3-DIARILPROP-2-EN-1-ONAS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE - Google Patents

1,3-DIARILPROP-2-EN-1-ONAS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE

Info

Publication number
GT200200252A
GT200200252A GT200200252A GT200200252A GT200200252A GT 200200252 A GT200200252 A GT 200200252A GT 200200252 A GT200200252 A GT 200200252A GT 200200252 A GT200200252 A GT 200200252A GT 200200252 A GT200200252 A GT 200200252A
Authority
GT
Guatemala
Prior art keywords
diarilprop
onas
compositions
contain
tumor
Prior art date
Application number
GT200200252A
Other languages
Spanish (es)
Inventor
Patrick Mailliet
Cecile Combeau
Marie-Christine Bissery
Marie-Pierre Cherrier
Thomas Caulfield
Gilles Tiraboschi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200200252A publication Critical patent/GT200200252A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL I EN DONDE AR,AR2,X,Y, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS PRESENTAN UNA ACTIVIDAD ANTICANCEROSA Y EN PARTICULAR, UNA ACTIVIDAD INHIBIDORA DE POLIMERIZACION DE LA TUBULINA OBSERVANDOSE LA NECROSIS DEL TUMOR QUE SE PRODUCE EN LOS MINUTOS QUE SIGUEN A LA INYECCION Y EN EL QUE EL NUCLEO DEL TUMOR SE DESTRUYE TOTALMENTE EN MENOS DE 1 DIA, SIN EFECTO APARENTE SOBRE LAS CELULAS SANAS CONTIGUAS.THE PRESENT INVENTION REFERS TO COMPOUNDS OF GENERAL FORMULA I WHERE AR, AR2, X, Y, ARE FUNCTIONAL GROUPS DESCRIBED IN THE RECORD. THESE COMPOUNDS PRESENT AN ANTI-BANK AND IN PARTICULAR ACTIVITY, AN INHIBITING POLYMERIZATION ACTIVITY OF THE TUBULIN OBSERVING THE NECROSIS OF THE TUMOR THAT IS PRODUCED IN THE MINUTES THAT FOLLOW THE INJECTION AND IN WHICH THE NUCLEUS OF THE TUMOR IS DESTROYED , WITHOUT APPEARING EFFECT ON CONTIGING HEALTHY CELLS.

GT200200252A 2001-12-05 2002-11-29 1,3-DIARILPROP-2-EN-1-ONAS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE GT200200252A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0115739A FR2833008B1 (en) 2001-12-05 2001-12-05 1,3-DIARYLPROP-2-IN-1-ONES, COMPOSITIONS CONTAINING THEM, AND USE

Publications (1)

Publication Number Publication Date
GT200200252A true GT200200252A (en) 2003-11-11

Family

ID=8870150

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200200252A GT200200252A (en) 2001-12-05 2002-11-29 1,3-DIARILPROP-2-EN-1-ONAS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE

Country Status (4)

Country Link
FR (1) FR2833008B1 (en)
GT (1) GT200200252A (en)
NO (1) NO20042803L (en)
ZA (1) ZA200404390B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904697A (en) * 1987-04-09 1990-02-27 Merrell Dow Pharmaceuticals Inc. Controlling the growth of certain tumor tissue with chalcone derivatives
WO1999000114A2 (en) * 1997-06-26 1999-01-07 Statens Serum Institut Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones

Also Published As

Publication number Publication date
NO20042803L (en) 2004-08-31
ZA200404390B (en) 2005-02-07
FR2833008A1 (en) 2003-06-06
FR2833008B1 (en) 2004-05-21

Similar Documents

Publication Publication Date Title
BRPI0418031A (en) phosphonate-substituted kinase inhibitors
AR011116A1 (en) N-HYDROXY-BETA-SULFONIL PROPIONAMIDE DERIVED COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT
GT200100005A (en) TREATMENT OF NEURODEGENERATIVE DISEASE
GT199700085A (en) PHOSPHINATE BASED MATRIO METALOPROTEASE INHIBITORS
GT200300031A (en) SUBSTITUTE INDAZOLS, COMPOSITIONS THAT CONTAIN THEM, MANUFACTURING AND USE PROCEDURE
EA200300171A1 (en) CYCLOPENTANOINDOLS, COMPOSITIONS CONTAINING THE COMPONENTS, AND METHODS OF TREATMENT
ECSP003610A (en) PYRIMIDINE-2,4,6 METALOPROTEIN INHIBITING TRIONES
PA8586001A1 (en) INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES
GT200300129A (en) DERIVATIVES OF HETEROARILAMIDA BENZO CONDENSED OF USEFUL TIENOPIRIDINS AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THE SAME AND METHOD FOR USE
HN2001000244A (en) SPIROPIRIMIDIN INHIBITORS - 2, 4, 6 - TRIONA METALOPROTEINASAS.
CL2004000720A1 (en) COMPOUNDS DERIVED FROM PIRAZOLIDINA-1,2-DICARBOXILDIFENILAMIDA, INHIBITORS OF THE COAGULATION FACTORS Xa, VIIa; PREPARATION PROCESS; INTERMEDIARY COMPOUNDS; PHARMACEUTICAL COMPOSITION; PHARMACEUTICAL KIT; AND ITS USE TO TREAT THROMBOSIS, INFAR
CY1109328T1 (en) THIENODIBENZOAZULENIUM COMPOUNDS AS TUMOR NECROSION FACTOR INHIBITORS
GT200600398A (en) ISOINDOL-IMIDA COMPOUNDS AND COMPOSITIONS INCLUDING THEM AND METHODS FOR USE
BR0116115A (en) Carboxamide derivatives and their use in the treatment of thromboembolic diseases and tumors.
EA200500893A1 (en) TRICYCLIC COMPOUNDS, REPRESENTING PROTECTION KINASE INHIBITORS, TO INCREASE THE EFFECTIVENESS OF ANTI-TUMOR AGENTS AND RADIATIVE THERAPY
DK1163208T3 (en) Caspase Inhibitors and Uses thereof
BR0309281A (en) Metalloproteinase inhibitor triaryl oxy-spiro-pyrimidine-2,4,6-triones
GT200100196A (en) NEW TIADIAZOLS AND OXADIAZOLS AND ITS USE AS INHIBITORS OF PHOSPHODIESTERASA-7.
BR0312232A (en) Caspase inhibitors and their uses
NO20055612L (en) Anti-inflammatory phosphonate compounds
GT200300105A (en) INHIBITORS OF RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUS AND COMPOSITIONS AND TREATMENTS QUELOUSAN
UY26564A1 (en) FACTOR XA INHIBITORS WITH ARYL - AMIDINES AND THEIR DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EA200400708A1 (en) INHIBITORS 11-BETA-HYDROXYSTEROID DEGYDROGENASE TYPE 1
GT200100145A (en) PIRROLIDINE DERIVATIVES
GT200200252A (en) 1,3-DIARILPROP-2-EN-1-ONAS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE