GT200200178A - SULFONAMIDE DERIVATIVES - Google Patents

SULFONAMIDE DERIVATIVES

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Publication number
GT200200178A
GT200200178A GT200200178A GT200200178A GT200200178A GT 200200178 A GT200200178 A GT 200200178A GT 200200178 A GT200200178 A GT 200200178A GT 200200178 A GT200200178 A GT 200200178A GT 200200178 A GT200200178 A GT 200200178A
Authority
GT
Guatemala
Prior art keywords
sulfonamide
derivatives
sulfonamide derivatives
inflatal
chemioquine
Prior art date
Application number
GT200200178A
Other languages
Spanish (es)
Inventor
Ying Fu Li
Akihiko Watanabe
Timothy B Lowinger
Kevin Bacon
Norihiro Kawamura
Takuya Shinatani
Tetsuo Kikuchi
Toshiya Moriwaki
Klaus Urbahns
Keiko Fukushima
Noriko Nunami
Takashi Yoshino
Toshiki Murata
Megumi Yamaguchi
Hiroko Katsumata
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200200178A publication Critical patent/GT200200178A/en

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE SULFONAMIDA DE FORMULA GENERAL (I) EN DONDE Z1, Z2, Y,X,R5,R6,R7, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS DERIVADOS DE SULFONAMIDA TIENEN ACTIVIDAD ANTAGONISTA DEL RECEPTOR 3 DE QUIMIOQUINA DE TIPO CC (CCR3) POR LO QUE SON UTILES EN UNA AMPLIA VARIEDAD DE PATOLOGIAS TALES COMO CASOS DE ASMA, DERMATITIS ATOPICA, RINITIS ALERGICA Y OTROS TRASTORNOS INFLAMATORIOS/INMUNOLOGICOS.THE PRESENT INVENTION REFERS TO SULFONAMIDE DERIVATIVES OF GENERAL FORMULA (I) WHERE Z1, Z2, Y, X, R5, R6, R7, ARE FUNCTIONAL GROUPS DESCRIBED IN THE RECORD. THESE DERIVATIVES OF SULFONAMIDE HAVE ANTAGONIST ACTIVITY OF THE CC TYPE CHEMIOQUINE RECEIVER 3 (CCR3) SO THAT THEY ARE USEFUL IN A WIDE VARIETY OF SUCH PATHOLOGIES AS CASES OF ASTHMA, ATOPIC DERMATITIS, ALLERGIC RHINITIS AND OTHER INFLATAL / INFORMATIC DISORDERS.

GT200200178A 2001-09-07 2002-09-05 SULFONAMIDE DERIVATIVES GT200200178A (en)

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