GT200100037A - THE 5-ALQUILPIRIDO (2,3-D) PYRIMIDINS ARE INHIBITORS OF THYROSINE KINES AND DEPENDS ON THE CYCLINE. - Google Patents
THE 5-ALQUILPIRIDO (2,3-D) PYRIMIDINS ARE INHIBITORS OF THYROSINE KINES AND DEPENDS ON THE CYCLINE.Info
- Publication number
- GT200100037A GT200100037A GT200100037A GT200100037A GT200100037A GT 200100037 A GT200100037 A GT 200100037A GT 200100037 A GT200100037 A GT 200100037A GT 200100037 A GT200100037 A GT 200100037A GT 200100037 A GT200100037 A GT 200100037A
- Authority
- GT
- Guatemala
- Prior art keywords
- cycline
- inhibitors
- depends
- alquilpirido
- pyrimidins
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
ESTA INVENCION SE REFIERE A LA 5ALQUILPRIDOPIRIMIDINAS CON INHIBIDORES DE LAS CINASAS QUE DEPENDEN DE LA CICLINA, EN PARTICULAR DE LA CINASA 4 QUE DEPENDE DE LA CICLINA. LOS COMPUESTOS DE LA INVENCION SON UTILES PARA EL TRATAMIENTO DE LA INFLAMACION, LAS ENFERMEDADES PROLIFERATIVAS DE LAS CELULAS COMO EL CANCER Y LA RESTENOSIS, Y LAS ENFERMEDADES NEURODEGENERATIVAS, COMO LA ENFERMEDAD DE ALZHEIMER.THIS INVENTION REFERS TO THE 5ALQUILPRIDOPIRIMIDINAS WITH INHIBITORS OF THE KINASES THAT DEPEND ON THE CYCLINE, IN PARTICULAR OF THE KINASE 4 THAT DEPENDS ON THE CYCLINE. THE COMPOUNDS OF THE INVENTION ARE USEFUL FOR THE TREATMENT OF INFLAMMATION, PROLIFERATIVE DISEASES OF CELLS LIKE CANCER AND RESTENOSIS, AND NEURODEGENERATIVE DISEASES, LIKE ALZHEIMER'S DISEASE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18712400P | 2000-03-06 | 2000-03-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200100037A true GT200100037A (en) | 2002-03-04 |
Family
ID=22687699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200100037A GT200100037A (en) | 2000-03-06 | 2001-03-05 | THE 5-ALQUILPIRIDO (2,3-D) PYRIMIDINS ARE INHIBITORS OF THYROSINE KINES AND DEPENDS ON THE CYCLINE. |
Country Status (36)
Country | Link |
---|---|
EP (1) | EP1268476A1 (en) |
JP (1) | JP2003528101A (en) |
KR (1) | KR20020075805A (en) |
CN (1) | CN1422268A (en) |
AP (1) | AP2002002643A0 (en) |
AR (1) | AR034119A1 (en) |
AU (1) | AU2001233028A1 (en) |
BG (1) | BG107161A (en) |
BR (1) | BR0109056A (en) |
CA (1) | CA2401368A1 (en) |
CO (1) | CO5280200A1 (en) |
CR (1) | CR6736A (en) |
CZ (1) | CZ20022929A3 (en) |
DZ (1) | DZ3308A1 (en) |
EA (1) | EA200200802A1 (en) |
EE (1) | EE200200506A (en) |
GT (1) | GT200100037A (en) |
HN (1) | HN2001000040A (en) |
HR (1) | HRP20020798A2 (en) |
HU (1) | HUP0300136A2 (en) |
IL (1) | IL151480A0 (en) |
IS (1) | IS6524A (en) |
MA (1) | MA26881A1 (en) |
MX (1) | MXPA02008535A (en) |
NO (1) | NO20024235L (en) |
NZ (1) | NZ520962A (en) |
OA (1) | OA12227A (en) |
PA (1) | PA8513201A1 (en) |
PE (1) | PE20011177A1 (en) |
PL (1) | PL358271A1 (en) |
SK (1) | SK12472002A3 (en) |
SV (1) | SV2001000338A (en) |
TN (1) | TNSN01036A1 (en) |
WO (1) | WO2001070741A1 (en) |
YU (1) | YU66502A (en) |
ZA (1) | ZA200207110B (en) |
Families Citing this family (81)
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CZ20031125A3 (en) | 2000-10-23 | 2003-10-15 | Smithkline Beecham Corporation | Novel compounds |
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EP1364950A4 (en) * | 2001-02-26 | 2005-03-09 | Tanabe Seiyaku Co | Pyridopyrimidine or naphthyridine derivative |
US20030100572A1 (en) * | 2001-06-21 | 2003-05-29 | Ariad Pharmaceuticals,Inc. | Novel pyridopyrimidones and uses thereof |
US20030105115A1 (en) * | 2001-06-21 | 2003-06-05 | Metcalf Chester A. | Novel pyridopyrimidines and uses thereof |
EA007395B3 (en) * | 2002-01-22 | 2018-02-28 | Уорнер-Ламберт Компани Ллс | 2-(PYRIDINE-2-YLAMINO)PYRIDO[2,3-d]PYRIMIDIN-7-ONES |
PL373339A1 (en) | 2002-04-19 | 2005-08-22 | Smithkline Beecham Corporation | Novel compounds |
CA2494061C (en) | 2002-07-31 | 2011-06-14 | Wayne R. Danter | Protein tyrosine kinase inhibitors |
ATE380810T1 (en) | 2002-10-09 | 2007-12-15 | Critical Outcome Technologies | PROTEIN TYROSINE KINASE INHIBITORS |
WO2004065378A1 (en) * | 2003-01-17 | 2004-08-05 | Warner-Lambert Company Llc | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
AU2004268621C1 (en) | 2003-08-29 | 2011-08-18 | Exelixis, Inc. | c-Kit modulators and methods of use |
WO2005047284A1 (en) | 2003-11-13 | 2005-05-26 | F. Hoffmann-La Roche Ag | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones |
DE102004029784A1 (en) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Novel 2-Benzylaminodihydropteridinones, process for their preparation and their use as medicaments |
DE102004033670A1 (en) | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New pyridodihydropyrazinone, process for its preparation and its use as a medicament |
FR2873118B1 (en) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS |
US20060074088A1 (en) | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
US7728134B2 (en) | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
US7759485B2 (en) | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
US20060035903A1 (en) | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
EP1630163A1 (en) | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinones, methods for their preparation and their use as drugs |
CA2575804A1 (en) * | 2004-08-26 | 2006-03-02 | Boehringer Ingelheim International Gmbh | Pteridinones used as plk (polo like kinase) inhibitors |
DE102004058337A1 (en) | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for the preparation of fused piperazin-2-one derivatives |
AU2006204724A1 (en) | 2005-01-14 | 2006-07-20 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
EP1868612A4 (en) | 2005-03-25 | 2010-03-24 | Glaxo Group Ltd | Novel compounds |
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MX2007012951A (en) | 2005-03-25 | 2008-01-11 | Glaxo Group Ltd | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives. |
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BRPI0715566A2 (en) * | 2006-10-16 | 2013-07-02 | Gpc Biotech Inc | compound, prodrug, pharmaceutical composition, use of a compound, method for inhibiting cell proliferation and method for synthesizing a compound |
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BRPI0809998B8 (en) * | 2007-04-03 | 2021-05-25 | Array Biopharma Inc | imidazo[1,2-a]pyridine compound as receptor tyrosine kinase inhibitors, their uses, their preparation processes and pharmaceutical compositions |
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WO2016015597A1 (en) * | 2014-07-26 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | Compounds as cdk small-molecule inhibitors and uses thereof |
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US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
TWI646094B (en) * | 2016-06-01 | 2019-01-01 | 大陸商貝達藥業股份有限公司 | Crystal form of inhibitory protein kinase active compound and application thereof |
LT3497103T (en) | 2016-08-15 | 2021-07-26 | Pfizer Inc. | Pyridopyrimdinone cdk2/4/6 inhibitors |
CN110809576B (en) * | 2017-03-03 | 2022-08-30 | 奥克兰联合服务有限公司 | FGFR kinase inhibitor and pharmaceutical use |
KR20200131246A (en) | 2018-02-15 | 2020-11-23 | 누베이션 바이오 인크. | Heterocyclic compounds as kinase inhibitors |
CN113166148B (en) * | 2018-12-07 | 2024-04-12 | 杭州英创医药科技有限公司 | Heterocyclic compounds as CDK-HDAC dual pathway inhibitors |
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JP2024508901A (en) * | 2021-03-08 | 2024-02-28 | 曁南大学 | Pyridopyrimidine compounds and their uses |
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Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
EP0964864B1 (en) * | 1997-02-05 | 2008-04-09 | Warner-Lambert Company LLC | Pyrido 2,3-d pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
ES2310039T3 (en) * | 1998-05-26 | 2008-12-16 | Warner-Lambert Company Llc | BICYCLE PYRIMIDINES AND BICYCLE 3,4-DIHYDROPIRIMIDINS AS INHIBITORS OF CELL PROLIFERATION. |
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2001
- 2001-01-29 SK SK1247-2002A patent/SK12472002A3/en unknown
- 2001-01-29 EA EA200200802A patent/EA200200802A1/en unknown
- 2001-01-29 KR KR1020027011627A patent/KR20020075805A/en not_active Application Discontinuation
- 2001-01-29 HU HU0300136A patent/HUP0300136A2/en unknown
- 2001-01-29 MX MXPA02008535A patent/MXPA02008535A/en not_active Application Discontinuation
- 2001-01-29 DZ DZ013308A patent/DZ3308A1/en active
- 2001-01-29 AU AU2001233028A patent/AU2001233028A1/en not_active Abandoned
- 2001-01-29 JP JP2001568942A patent/JP2003528101A/en not_active Abandoned
- 2001-01-29 PL PL01358271A patent/PL358271A1/en not_active Application Discontinuation
- 2001-01-29 CN CN01807590A patent/CN1422268A/en active Pending
- 2001-01-29 EE EEP200200506A patent/EE200200506A/en unknown
- 2001-01-29 YU YU66502A patent/YU66502A/en unknown
- 2001-01-29 IL IL15148001A patent/IL151480A0/en unknown
- 2001-01-29 CZ CZ20022929A patent/CZ20022929A3/en unknown
- 2001-01-29 WO PCT/US2001/002657 patent/WO2001070741A1/en active IP Right Grant
- 2001-01-29 CA CA002401368A patent/CA2401368A1/en not_active Abandoned
- 2001-01-29 OA OA1200200281A patent/OA12227A/en unknown
- 2001-01-29 EP EP01905114A patent/EP1268476A1/en not_active Withdrawn
- 2001-01-29 NZ NZ520962A patent/NZ520962A/en unknown
- 2001-01-29 BR BR0109056-9A patent/BR0109056A/en not_active IP Right Cessation
- 2001-01-29 AP APAP/P/2002/002643A patent/AP2002002643A0/en unknown
- 2001-03-02 TN TNTNSN01036A patent/TNSN01036A1/en unknown
- 2001-03-05 HN HN2001000040A patent/HN2001000040A/en unknown
- 2001-03-05 AR ARP010101039A patent/AR034119A1/en unknown
- 2001-03-05 SV SV2001000338A patent/SV2001000338A/en not_active Application Discontinuation
- 2001-03-05 PE PE2001000216A patent/PE20011177A1/en not_active Application Discontinuation
- 2001-03-05 GT GT200100037A patent/GT200100037A/en unknown
- 2001-03-05 CO CO01017398A patent/CO5280200A1/en not_active Application Discontinuation
- 2001-03-05 PA PA20018513201A patent/PA8513201A1/en unknown
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2002
- 2002-08-23 CR CR6736A patent/CR6736A/en not_active Application Discontinuation
- 2002-08-23 IS IS6524A patent/IS6524A/en unknown
- 2002-09-04 MA MA26801A patent/MA26881A1/en unknown
- 2002-09-04 ZA ZA200207110A patent/ZA200207110B/en unknown
- 2002-09-05 NO NO20024235A patent/NO20024235L/en not_active Application Discontinuation
- 2002-10-02 BG BG107161A patent/BG107161A/en unknown
- 2002-10-04 HR HR20020798A patent/HRP20020798A2/en not_active Application Discontinuation
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