GR960100116A - Process for the preparation of 1-cycloprolyl-6-fluoro-1,4- dihydro-7-{(1S,4S)-5-methyl-2,5-diazabicyclo{2,2,1)-hept-2-yl}-4-oxo-3-quinolinocarboxylic acid and the salts. - Google Patents

Process for the preparation of 1-cycloprolyl-6-fluoro-1,4- dihydro-7-{(1S,4S)-5-methyl-2,5-diazabicyclo{2,2,1)-hept-2-yl}-4-oxo-3-quinolinocarboxylic acid and the salts.

Info

Publication number
GR960100116A
GR960100116A GR960100116A GR960100116A GR960100116A GR 960100116 A GR960100116 A GR 960100116A GR 960100116 A GR960100116 A GR 960100116A GR 960100116 A GR960100116 A GR 960100116A GR 960100116 A GR960100116 A GR 960100116A
Authority
GR
Greece
Prior art keywords
cycloprolyl
hept
diazabicyclo
dihydro
oxo
Prior art date
Application number
GR960100116A
Other languages
Greek (el)
Inventor
Gonzalez Hernandez Pedro
Luisa Salas Gonzalez Maria
Picornell Darder Carlos
Original Assignee
Quimica Sintetica S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quimica Sintetica S.A. filed Critical Quimica Sintetica S.A.
Publication of GR960100116A publication Critical patent/GR960100116A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Abstract

The process is characterized by the treatment of C1-C4 alkyl
GR960100116A 1995-04-12 1996-04-03 Process for the preparation of 1-cycloprolyl-6-fluoro-1,4- dihydro-7-{(1S,4S)-5-methyl-2,5-diazabicyclo{2,2,1)-hept-2-yl}-4-oxo-3-quinolinocarboxylic acid and the salts. GR960100116A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09500782A ES2092963B1 (en) 1995-04-12 1995-04-12 PROCEDURE FOR THE PREPARATION OF ACID 1-CICLOPROPIL-6-FLUORO-1, 4-DIHIDRO-7- (1S, 4S) -5-METHYL-2,5-DIAZABICICLO (2.2.1) HEPT-2-IL) -4 -OXO-3-QUINOLINCARBOXILICO AND ITS SALTS.

Publications (1)

Publication Number Publication Date
GR960100116A true GR960100116A (en) 1996-12-31

Family

ID=8290154

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960100116A GR960100116A (en) 1995-04-12 1996-04-03 Process for the preparation of 1-cycloprolyl-6-fluoro-1,4- dihydro-7-{(1S,4S)-5-methyl-2,5-diazabicyclo{2,2,1)-hept-2-yl}-4-oxo-3-quinolinocarboxylic acid and the salts.

Country Status (13)

Country Link
KR (1) KR960037676A (en)
AR (1) AR001560A1 (en)
AT (1) ATA65396A (en)
CZ (1) CZ97496A3 (en)
ES (1) ES2092963B1 (en)
FI (1) FI961583A (en)
GR (1) GR960100116A (en)
HU (1) HUP9600941A3 (en)
MX (1) MX9601351A (en)
NO (1) NO961442L (en)
PL (1) PL313697A1 (en)
PT (1) PT101864B (en)
SK (1) SK46896A3 (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215650A2 (en) * 1985-09-18 1987-03-25 Pfizer Inc. Substituted bridged-diazabicycloalkyl quinolone carboxylic acids
WO1987003595A1 (en) * 1985-12-09 1987-06-18 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Norfloxacin intermediate
WO1987003587A1 (en) * 1985-12-09 1987-06-18 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acids
EP0251308A1 (en) * 1986-07-04 1988-01-07 Chemie Linz Gesellschaft m.b.H. 4-Quinolone-3-carboxylic-acid derivatives, process for their synthesis and pharmaceutical preparations containing them
WO1988007993A1 (en) * 1987-04-08 1988-10-20 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acids
WO1988010253A1 (en) * 1987-06-24 1988-12-29 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acid derivatives
WO1990006922A1 (en) * 1988-12-22 1990-06-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acid derivatives
EP0464823A1 (en) * 1990-07-06 1992-01-08 Kyorin Pharmaceutical Co., Ltd. (6,7-Substituted-8-alkoxy-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid-O3,O4)bis(acyloxy-O)borates and the salts thereof, and methods for their manufacture

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU46451B (en) * 1987-04-08 1993-10-20 Chinoin Gyogyszer Es Vegyeszeti Ter Mekek Gyara Rt. PROCESS FOR PREPARATION OF MIXED ANHYDRIDS OF QUINOLINE-CARBOXYL AND BORIC ACID
NZ224150A (en) * 1987-04-08 1990-11-27 Chinoin Gyogyszer Es Vegyeszet Preparation of piperazinyl-substituted quinoline derivatives

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215650A2 (en) * 1985-09-18 1987-03-25 Pfizer Inc. Substituted bridged-diazabicycloalkyl quinolone carboxylic acids
WO1987003595A1 (en) * 1985-12-09 1987-06-18 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Norfloxacin intermediate
WO1987003587A1 (en) * 1985-12-09 1987-06-18 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acids
EP0251308A1 (en) * 1986-07-04 1988-01-07 Chemie Linz Gesellschaft m.b.H. 4-Quinolone-3-carboxylic-acid derivatives, process for their synthesis and pharmaceutical preparations containing them
WO1988007993A1 (en) * 1987-04-08 1988-10-20 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acids
WO1988010253A1 (en) * 1987-06-24 1988-12-29 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acid derivatives
WO1990006922A1 (en) * 1988-12-22 1990-06-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acid derivatives
EP0464823A1 (en) * 1990-07-06 1992-01-08 Kyorin Pharmaceutical Co., Ltd. (6,7-Substituted-8-alkoxy-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid-O3,O4)bis(acyloxy-O)borates and the salts thereof, and methods for their manufacture

Also Published As

Publication number Publication date
NO961442L (en) 1996-10-14
AR001560A1 (en) 1997-11-26
PT101864B (en) 1997-12-31
PT101864A (en) 1997-01-31
ATA65396A (en) 1998-09-15
FI961583A (en) 1996-10-13
SK46896A3 (en) 1997-07-09
HUP9600941A2 (en) 1997-06-30
PL313697A1 (en) 1996-10-14
HU9600941D0 (en) 1996-06-28
ES2092963B1 (en) 1997-12-16
ES2092963A1 (en) 1996-12-01
MX9601351A (en) 1997-04-30
NO961442D0 (en) 1996-04-11
HUP9600941A3 (en) 1998-01-28
KR960037676A (en) 1996-11-19
FI961583A0 (en) 1996-04-11
CZ97496A3 (en) 1996-10-16

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