GR920100523A - Compounds. - Google Patents

Compounds.

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Publication number
GR920100523A
GR920100523A GR920100523A GR920100523A GR920100523A GR 920100523 A GR920100523 A GR 920100523A GR 920100523 A GR920100523 A GR 920100523A GR 920100523 A GR920100523 A GR 920100523A GR 920100523 A GR920100523 A GR 920100523A
Authority
GR
Greece
Prior art keywords
useful
treatment
compounds
disease states
production
Prior art date
Application number
GR920100523A
Other languages
Greek (el)
Inventor
Jutta Forster Cornelia
Benjamin Christensen Siegfried
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of GR920100523A publication Critical patent/GR920100523A/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Περιγράφονται νέα παράγωγα κυκλοεξαν-υλιδενίου τα οποία αναστέλλουν την παραγωγήν του TUMOR NECROSIS FACTOR (Παράγοντος Νεκρώσεως Ογκου) και είναι χρήσιμα εις την θεραπευτικήν αγωγήν νοσηρών καταστάσεων μεσολαβουμένων ή επιτεινουμένων υπό παραγωγής TNF. Αι ενώσεις της παρούσης εφευρέσεως είναι επίσης χρήσιμοι εις την παρεμβολή ή αναστολήν ενζυματικής ή καταλυτικής δράσεως της φωσφοροδιεστεράσης IV και είναι συνεπώς χρήσιμοι εις την θεραπευτικήν αγωγήν νοσηρών καταστάσεων εχούσων ανάγκην παρεμβολής ή αναστολής αυτών.ωNew cyclohexanylidene derivatives are described which inhibit the production of TUMOR NECROSIS FACTOR and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful in interfering with or inhibiting the enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of interference or inhibition thereof.

GR920100523A 1992-11-26 1992-11-26 Compounds. GR920100523A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR92100523 1992-11-26

Publications (1)

Publication Number Publication Date
GR920100523A true GR920100523A (en) 1994-07-29

Family

ID=10941244

Family Applications (1)

Application Number Title Priority Date Filing Date
GR920100523A GR920100523A (en) 1992-11-26 1992-11-26 Compounds.

Country Status (1)

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GR (1) GR920100523A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2723937A1 (en) * 1976-06-03 1977-12-15 Upjohn Co 4-AMINO-4-ARYLCYCLOHEXANONE COMPOUNDS, METHODS FOR THEIR MANUFACTURING, INTERMEDIATES USED IN THEIR MANUFACTURING, AND MEDICINAL PRODUCTS
US4795757A (en) * 1984-09-04 1989-01-03 Rorer Pharmaceutical Corporation Bisarylamines
WO1991015451A1 (en) * 1990-04-05 1991-10-17 Smithkline Beecham Pharma Gmbh Novel derivatives of phenyl-cycloalkanes and -cycloalkenes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2723937A1 (en) * 1976-06-03 1977-12-15 Upjohn Co 4-AMINO-4-ARYLCYCLOHEXANONE COMPOUNDS, METHODS FOR THEIR MANUFACTURING, INTERMEDIATES USED IN THEIR MANUFACTURING, AND MEDICINAL PRODUCTS
US4795757A (en) * 1984-09-04 1989-01-03 Rorer Pharmaceutical Corporation Bisarylamines
WO1991015451A1 (en) * 1990-04-05 1991-10-17 Smithkline Beecham Pharma Gmbh Novel derivatives of phenyl-cycloalkanes and -cycloalkenes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 73, no. 21, 23 November 1970, Columbus, Ohio, US; abstract no. 109530f, '4-CYANO-4-PHENYLAMINOCYCLOHEXANES, BLOOD PRESSURE DEPRESSANTS' page 347 ; *

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