GR890100349A - Nucleoside and polynucleotide thiophosphoramidite and phosphorodithidate compounds and processes - Google Patents

Nucleoside and polynucleotide thiophosphoramidite and phosphorodithidate compounds and processes

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Publication number
GR890100349A
GR890100349A GR890100349A GR890100349A GR890100349A GR 890100349 A GR890100349 A GR 890100349A GR 890100349 A GR890100349 A GR 890100349A GR 890100349 A GR890100349 A GR 890100349A GR 890100349 A GR890100349 A GR 890100349A
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GR
Greece
Prior art keywords
compounds
processes
phosphorodithidate
thiophosphoramidite
nucleoside
Prior art date
Application number
GR890100349A
Other languages
Greek (el)
Inventor
Wolfgang Brill
Marvin Caruthers
John Nielsen
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of GR890100349A publication Critical patent/GR890100349A/en

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Abstract

The invention hereby is related with a preparation method of new and useful nucleotid- thiophosphamides, poly nucleotid- phosphamide disulphates and poly nucleotid- thiophosphamid- phosphamid compounds as well as with processes where these compounds may be used to synthesise new mono nucleotides and poly nucleotides that have bonds of phosphodisulfate, phosphothiamate ester, phosphosulfate tri-esters and dianucleotid- phosphosulfate ester.
GR890100349A 1989-05-26 1989-05-26 Nucleoside and polynucleotide thiophosphoramidite and phosphorodithidate compounds and processes GR890100349A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR89100349 1989-05-26

Publications (1)

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GR890100349A true GR890100349A (en) 1994-03-31

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GR890100349A GR890100349A (en) 1989-05-26 1989-05-26 Nucleoside and polynucleotide thiophosphoramidite and phosphorodithidate compounds and processes

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GR (1) GR890100349A (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4373071A (en) * 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
JPS6251695A (en) * 1985-08-29 1987-03-06 Yuki Gosei Yakuhin Kogyo Kk Synthesis of phosphoroamidite
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4728730A (en) * 1984-09-12 1988-03-01 Wisconsin Alumini Research Foundation Synthesis of nucleoside thiophosphoanhydrides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4373071A (en) * 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4728730A (en) * 1984-09-12 1988-03-01 Wisconsin Alumini Research Foundation Synthesis of nucleoside thiophosphoanhydrides
JPS6251695A (en) * 1985-08-29 1987-03-06 Yuki Gosei Yakuhin Kogyo Kk Synthesis of phosphoroamidite

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 106, 1984, pages 6077-6079, The American Chemical Society, US; W.J. STEC et al.: "Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogues of oligodeoxyribonucleotides" *
JOURNAL OF THE CHEMICAL SOCIETY. PERKIN TRANSACTIONS I., no. 8, August 1987, pages 1645-1656; J. BARANIAK et al.: "Ribonucleoside cyclic 3',5'-phosphoramidates: Synthesis, stereochemistry, and conversion into ribonucleoside cyclic 3',5'-phosphorothioates and -[18OÜphosphates" *
PATENT ABSTRACTS OF JAPAN, vol. 11, no. 246 (C-439)[2693], 11th August 1987; & JP-A-62 51 695 (YUKI GOSEI YAKUHIN KOGYO K.K.) 06-03-1987 *
SYNTHESIS, no. 5, May 1980, pages 397-400, Georg Thieme Verlag, Stuttgart, DE; Z.J. LESNIKOWSKI et al.: "Thymidine 3'-(2-chlorophenyl)-phosphoranilidate as a key intermediate in the synthesis of tetrahymidylic acid bearing phosphoryl of phosphorothioyl end groups" *
TETRAHEDRON LETTERS, vol. 21, no. 43, 1980, pages 4153-4154, Pergamon Press, Oxford, GB; M.J. NEMER et al.: "Phosphoramidate analogues of diribonucleoside monophosphates" *
TETRAHEDRON LETTERS, vol. 27, no. 46, 1986, pages 5575-5578, Pergamon Journals Ltd, GB; B.C. FROEHLER: "Deoxynucleoside H-phosphonate diester intermediates in the synthesis of internucleotide phosphate analogues" *
TETRAHEDRON LETTERS, vol. 29, no. 24, 1988, pages 2911-2914, Pergamon Press, Oxford, GB; J. NIELSEN et al.: "Synthesis and characterization of dinucleoside phosphorodithioates" *
TETRAHEDRON LETTERS, vol. 29, no. 43, 1988, pages 5517-5520, Pergamon Press, Oxford, GB; W.K.-D. BRILL et al.: "Synthesis of dinucleoside phosphorodithioates via thioamidites" *
TETRAHEDRON LETTERS, vol. 29, no. 52, 1988, pages 6843-6846, Pergamon Press, Oxford, GB; N. FARSCHTSCHI et al.: "Preparation of a deoxynucleoside thiophosphoramidite intermediate in the synthesis of nucleoside phosphorodithioates" *
TETRAHEDRON LETTERS, vol. 3, no. 5, 1989, pages 543-546, Pergamon Press, Oxford, GB; A. GRANDAS et al.: "Synthesis of deoxycytidine oligomers containing phosphorodithioate linkages" *
TETRAHEDRON LETTERS, vol. 30, no. 16, 1989, pages 2157-2160, Pergamon Press, Oxford, GB; J. STAWINSKI et al.: "Nucleoside H-phosphonates. X. Studies on nucleoside hydrogenphosphonothioate diester synthesis" *

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