GR871667B - Selected n- substituted adenosines having selective a2 binding activity - Google Patents

Selected n- substituted adenosines having selective a2 binding activity

Info

Publication number
GR871667B
GR871667B GR871667A GR870101667A GR871667B GR 871667 B GR871667 B GR 871667B GR 871667 A GR871667 A GR 871667A GR 870101667 A GR870101667 A GR 870101667A GR 871667 B GR871667 B GR 871667B
Authority
GR
Greece
Prior art keywords
selective
binding activity
substituted adenosines
adenosines
substituted
Prior art date
Application number
GR871667A
Other languages
Greek (el)
Inventor
Alexander James Bridges
Bharat K Trivedi
Daniel Fred Ortwine
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of GR871667B publication Critical patent/GR871667B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
GR871667A 1986-10-31 1987-10-30 Selected n- substituted adenosines having selective a2 binding activity GR871667B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92518586A 1986-10-31 1986-10-31
US9083087A 1987-08-28 1987-08-28

Publications (1)

Publication Number Publication Date
GR871667B true GR871667B (en) 1988-03-03

Family

ID=26782679

Family Applications (1)

Application Number Title Priority Date Filing Date
GR871667A GR871667B (en) 1986-10-31 1987-10-30 Selected n- substituted adenosines having selective a2 binding activity

Country Status (3)

Country Link
AU (1) AU8276187A (en)
GR (1) GR871667B (en)
WO (1) WO1988003147A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
JPH0725785B2 (en) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 Adenosine derivative and pharmaceutical composition containing the compound as an active ingredient
US5055569A (en) * 1989-10-19 1991-10-08 G. D. Searle & Co. N-(6)-substituted adenosine compounds
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
AU654507B2 (en) * 1990-09-25 1994-11-10 Rhone-Poulenc Rorer International (Holdings) Inc. Compounds having antihypertensive and anti-ischemic properties
HUT61567A (en) * 1990-12-07 1993-01-28 Sandoz Ag Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate
FR2685918B1 (en) * 1992-01-08 1995-06-23 Union Pharma Scient Appl NOVEL ADENOSINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2687678B1 (en) * 1992-01-31 1995-03-31 Union Pharma Scient Appl NOVEL ADENOSINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
EP0601322A3 (en) * 1992-10-27 1994-10-12 Nippon Zoki Pharmaceutical Co Adenosindeaminase inhibitor.
WO1994023723A1 (en) * 1993-04-15 1994-10-27 New York University Adenosine receptor agonists for the promotion of wound healing
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
GB9414193D0 (en) * 1994-07-14 1994-08-31 Glaxo Group Ltd Compounds
WO1997033591A1 (en) * 1996-03-13 1997-09-18 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
GB9723566D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
YU44900A (en) 1998-01-31 2003-01-31 Glaxo Group Limited 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU81100A (en) 1998-06-23 2003-10-31 Glaxo Group Limited 2-(purin-9-yl)tetrahydrofuran -3,4-diol derivatives
JP3619017B2 (en) 1998-06-24 2005-02-09 日本臓器製薬株式会社 New arabinosyladenine derivatives
CA2347512C (en) * 1998-10-16 2005-12-06 Pfizer Inc. Adenine derivatives
GB9924361D0 (en) 1999-10-14 1999-12-15 Pfizer Ltd Purine derivatives
GB9924363D0 (en) * 1999-10-14 1999-12-15 Pfizer Central Res Purine derivatives
US6921753B2 (en) 2000-06-27 2005-07-26 Pfizer Inc Purine derivatives
GB0015727D0 (en) * 2000-06-27 2000-08-16 Pfizer Ltd Purine derivatives
GB0022695D0 (en) 2000-09-15 2000-11-01 Pfizer Ltd Purine Derivatives
EP1375508A1 (en) * 2002-06-27 2004-01-02 Aventis Pharma Deutschland GmbH N6-substituted adenosine analogues and their use as pharmaceutical agents
US7265111B2 (en) 2002-06-27 2007-09-04 Sanofi-Aventis Deutschland Gmbh Adenosine analogues and their use as pharmaceutical agents
AR049384A1 (en) 2004-05-24 2006-07-26 Glaxo Group Ltd PURINA DERIVATIVES
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
ES2304112B1 (en) 2007-02-23 2009-08-13 Universidad De Zaragoza USE OF COMPOUNDS AS INHIBITORS OF HELICOBACTER FLAVODOXINE.
ES2304221B1 (en) 2007-03-02 2009-09-11 Universidad De Zaragoza COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY HELICOBACTER.
ES2304220B1 (en) 2007-03-02 2009-09-11 Universidad De Zaragoza COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES.
PE20140608A1 (en) 2010-09-22 2014-06-12 Alios Biopharma Inc REPLACED NUCLEOTIDE ANALOGS
AU2011349278C1 (en) 2010-12-22 2017-01-19 Alios Biopharma, Inc. Cyclic nucleotide analogs
PL2794627T3 (en) 2011-12-22 2019-04-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc Substituted phosphorothioate nucleotide analogs
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
NZ631601A (en) 2012-03-21 2016-06-24 Alios Biopharma Inc Solid forms of a thiophosphoramidate nucleotide prodrug
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2007273A1 (en) * 1970-02-18 1971-08-26 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof N (6) aralkyl adenosine derivatives and process for the preparation thereof
DE2238923A1 (en) * 1972-08-08 1974-02-14 Boehringer Mannheim Gmbh ACYLATED N (6) ARALKYL ADENOSINE DERIVATIVES AND METHOD FOR PREPARING THE SAME
CA1239397A (en) * 1983-08-01 1988-07-19 James A. Bristol N.sup.6-substituted adenosines
DE3406533A1 (en) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim USE OF ADENOSINE DERIVATIVES AS ANTIALLERGICA AND MEDICINAL PRODUCTS CONTAINING THEM
AU575438B2 (en) * 1984-10-26 1988-07-28 Warner-Lambert Company N6 - substituted deoxyribose analogues of adenosines

Also Published As

Publication number Publication date
WO1988003147A1 (en) 1988-05-05
AU8276187A (en) 1988-05-25

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