GR77713B - - Google Patents

Info

Publication number
GR77713B
GR77713B GR69461A GR820169461A GR77713B GR 77713 B GR77713 B GR 77713B GR 69461 A GR69461 A GR 69461A GR 820169461 A GR820169461 A GR 820169461A GR 77713 B GR77713 B GR 77713B
Authority
GR
Greece
Application number
GR69461A
Inventor
Daniel F Veber
Joshuas Boger
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of GR77713B publication Critical patent/GR77713B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR69461A 1981-10-08 1982-10-06 GR77713B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30985581A 1981-10-08 1981-10-08
US31255881A 1981-10-19 1981-10-19

Publications (1)

Publication Number Publication Date
GR77713B true GR77713B (el) 1984-09-25

Family

ID=26977061

Family Applications (1)

Application Number Title Priority Date Filing Date
GR69461A GR77713B (el) 1981-10-08 1982-10-06

Country Status (7)

Country Link
EP (1) EP0077028B1 (el)
CA (1) CA1258748A (el)
DE (1) DE3275094D1 (el)
DK (1) DK444682A (el)
ES (1) ES516294A0 (el)
GR (1) GR77713B (el)
PT (1) PT75653B (el)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3377497D1 (en) * 1982-09-15 1988-09-01 Haessle Ab Enzyme inhibitors
US4650661A (en) * 1982-09-15 1987-03-17 Aktiebolaget Hassle Enzyme inhibitors
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
GB2135773B (en) * 1983-01-31 1985-12-04 Boots Celltech Diagnostics Enzyme inhibitor labelled immunoassay
US4613676A (en) * 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
CA1254699A (en) 1984-03-12 1989-05-23 Jasjit S. Bindra Renin inhibitors containing statine or derivatives thereof
EP0156318A3 (en) * 1984-03-27 1988-07-06 Merck & Co. Inc. C-terminal amide cyclic renin inhibitors containing peptide isosteres
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
US4665052A (en) * 1984-03-27 1987-05-12 Merck & Co., Inc. Renin inhibitors containing homophe8 and a C-terminal amide cycle
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
US4668663A (en) * 1984-03-27 1987-05-26 Merck & Co., Inc. Renin inhibitors containing homophe8
US4663310A (en) * 1984-04-04 1987-05-05 Merck & Co., Inc. Renin inhibitors containing 2-substituted statine
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
FR2564844A1 (fr) * 1984-05-25 1985-11-29 Sanofi Sa Nouveaux peptides derives de la statine, procede d'obtention et compositions pharmaceutiques les contenant
EP0163237A3 (en) * 1984-05-29 1988-04-27 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
US4645759A (en) * 1984-06-22 1987-02-24 Abbott Laboratories Renin inhibiting compounds
US4652551A (en) * 1984-06-22 1987-03-24 Abbott Laboratories Renin inhibiting compounds
EP0486478A3 (en) * 1984-08-06 1992-08-12 The Upjohn Company Renin-inhibiting peptides
US4880781A (en) * 1984-08-06 1989-11-14 The Upjohn Company Renin inhibitory peptides containing an N-alkyl-histidine moiety
DE3438545A1 (de) * 1984-10-20 1986-04-24 Merck Patent Gmbh, 6100 Darmstadt Peptide
EP0181110A3 (en) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Histidine derivatives as renin inhibitors
DE3512128A1 (de) 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
EP0218688B1 (en) 1985-04-19 1990-09-12 The Upjohn Company Dihalo-statine substituted renin inhibitors
EP0206807A3 (en) * 1985-06-28 1988-01-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US4992562A (en) * 1985-08-09 1991-02-12 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US4853463A (en) * 1985-09-04 1989-08-01 Kissei Pharmaceutical Co., Ltd. Amino acid derivatives
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
CA1309555C (en) * 1986-02-27 1992-10-27 Suvit Thaisrivongs Inhibiting peptides having a dihydroxyethylene isostere transitionstate insert
US4705846A (en) * 1986-03-27 1987-11-10 The Upjohn Company Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
JPS6322081A (ja) * 1986-07-11 1988-01-29 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
US4743584A (en) * 1986-10-07 1988-05-10 Merck & Co., Inc. C-terminal amide cyclic renin inhibitors containing peptide isosteres
DE3640535A1 (de) * 1986-11-27 1988-06-01 Merck Patent Gmbh Peptide
DE3724197A1 (de) * 1987-07-22 1989-02-02 Merck Patent Gmbh Verfahren zur reduktion von ketonen
DE3840289A1 (de) * 1988-11-30 1990-05-31 Merck Patent Gmbh Aminosaeurederivate
US5674979A (en) * 1989-02-10 1997-10-07 Schramm; Wolfgang Agent for inhibiting symmetrical proteins, in particular enzymes
DE59009945D1 (de) * 1989-02-10 1996-01-18 Wolfgang Prof Dr Schramm Mittel zur hemmung von hiv-proteasen.
US5126326A (en) * 1989-06-06 1992-06-30 Bio-Mega, Inc. Enzyme inhibiting peptide derivatives
US5212157A (en) * 1989-06-06 1993-05-18 Bio-Mega, Inc. Enzyme inhibitors
DE4014421A1 (de) * 1990-05-05 1991-11-07 Merck Patent Gmbh Aminosaeurederivate
US5278326A (en) * 1991-03-18 1994-01-11 Warner-Lambert Company Substituted beta-ketoamide ACAT inhibitors
CN103370331B (zh) 2011-02-08 2017-02-15 默克专利股份有限公司 用于治疗关节病的氨基他汀衍生物
WO2014015934A1 (de) 2012-07-24 2014-01-30 Merck Patent Gmbh Hydroxystatin-derivate zur behandlung von arthrose

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873681A (en) 1972-02-16 1975-03-25 Lilly Co Eli Determination of increased amounts of renin in body fluids
DE2506601C3 (de) * 1974-02-28 1980-12-11 Sanraku-Ocean Co., Ltd., Tokio Tetrapeptide und Verfahren zu ihrer Herstellung
FR2399409A1 (fr) 1977-08-04 1979-03-02 Anvar Nouveaux derives de la pepstatine, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
PT75653B (en) 1985-12-09
EP0077028A3 (en) 1984-03-21
EP0077028A2 (en) 1983-04-20
CA1258748A (en) 1989-08-22
DE3275094D1 (en) 1987-02-19
PT75653A (en) 1982-11-01
ES8401016A1 (es) 1983-11-16
EP0077028B1 (en) 1987-01-14
ES516294A0 (es) 1983-11-16
DK444682A (da) 1983-04-09

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