GR75536B - - Google Patents

Info

Publication number
GR75536B
GR75536B GR67668A GR820167668A GR75536B GR 75536 B GR75536 B GR 75536B GR 67668 A GR67668 A GR 67668A GR 820167668 A GR820167668 A GR 820167668A GR 75536 B GR75536 B GR 75536B
Authority
GR
Greece
Prior art keywords
guanidino
halo
amino
guanidinopyrimidines
chloroguanidine
Prior art date
Application number
GR67668A
Other languages
Greek (el)
Inventor
David Lee Lado
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of GR75536B publication Critical patent/GR75536B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

2,4-Amino, guanidinopyrimidines have diuretic activity. A representative species of these compounds is 2-guanidino-4-amino-6-chloroguanidine which is prepared by the stepwise replacement of first the 2-halo of a 2,4,6-trihalopyrimidine by guanidino and then the 4-halo by ammonia.
GR67668A 1981-03-24 1982-03-22 GR75536B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/247,048 US4336254A (en) 1981-03-24 1981-03-24 Guanidinopyrimidine compounds, compositions and method of using as a diuretic

Publications (1)

Publication Number Publication Date
GR75536B true GR75536B (en) 1984-07-27

Family

ID=22933338

Family Applications (1)

Application Number Title Priority Date Filing Date
GR67668A GR75536B (en) 1981-03-24 1982-03-22

Country Status (8)

Country Link
US (1) US4336254A (en)
EP (1) EP0062439B1 (en)
JP (1) JPS57169471A (en)
AT (1) ATE12228T1 (en)
DE (1) DE3262592D1 (en)
DK (1) DK155284C (en)
GR (1) GR75536B (en)
IE (1) IE52634B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2422887A (en) * 1947-06-24 Pyrimidine compound and processes
US2295563A (en) * 1941-07-30 1942-09-15 Gen Electric Diazine derivatives
BE490235A (en) * 1948-07-21
CH408026A (en) 1961-07-02 1966-02-28 Wilhelm Jun Dr Kraus Process for the preparation of pyrimidine derivatives
US3284188A (en) * 1963-04-12 1966-11-08 Toyo Koatsu Ind Inc Method and composition for suppressing the nitrification of ammonium nitrogen in soil

Also Published As

Publication number Publication date
US4336254A (en) 1982-06-22
DK155284B (en) 1989-03-20
ATE12228T1 (en) 1985-04-15
DK134982A (en) 1982-09-25
IE820665L (en) 1982-09-24
DE3262592D1 (en) 1985-04-25
EP0062439B1 (en) 1985-03-20
EP0062439A1 (en) 1982-10-13
JPS57169471A (en) 1982-10-19
DK155284C (en) 1989-07-31
JPH0416467B2 (en) 1992-03-24
IE52634B1 (en) 1988-01-06

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