GR75053B - - Google Patents
Info
- Publication number
- GR75053B GR75053B GR66121A GR810166121A GR75053B GR 75053 B GR75053 B GR 75053B GR 66121 A GR66121 A GR 66121A GR 810166121 A GR810166121 A GR 810166121A GR 75053 B GR75053 B GR 75053B
- Authority
- GR
- Greece
- Prior art keywords
- chlorosulfonyl
- imide
- symptoms
- inhibiting
- bis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis(chlorosulfonyl)imide in the presence of a tertiary amine. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/191,644 US4321254A (en) | 1980-09-26 | 1980-09-26 | Antiallergic imidodisulfamides |
Publications (1)
Publication Number | Publication Date |
---|---|
GR75053B true GR75053B (en) | 1984-07-13 |
Family
ID=22706323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR66121A GR75053B (en) | 1980-09-26 | 1981-09-23 |
Country Status (8)
Country | Link |
---|---|
US (1) | US4321254A (en) |
EP (1) | EP0049135B1 (en) |
JP (1) | JPS5785370A (en) |
AT (1) | ATE7024T1 (en) |
DE (1) | DE3163096D1 (en) |
DK (1) | DK420781A (en) |
GR (1) | GR75053B (en) |
IE (1) | IE51596B1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1582884A (en) * | 1977-05-19 | 1981-01-14 | Beecham Group Ltd | Clavulanic acid derivatives their preparation and use |
DK330880A (en) * | 1979-08-03 | 1981-02-04 | Beecham Group Ltd | PROCEDURE FOR THE PREPARATION OF CLAVULANIC ACID DERIVATIVES |
EP0053893B1 (en) * | 1980-12-09 | 1985-03-20 | Beecham Group Plc | Derivatives of clavulanic acid, their preparation and their use |
NZ199200A (en) * | 1980-12-23 | 1984-07-31 | Beecham Group Ltd | Clavulanic acid derivatives and pharmaceutical compositions |
US4350698A (en) * | 1981-09-25 | 1982-09-21 | Smithkline Corporation | Antiallergic imidosulfamides |
EP0266949B1 (en) * | 1986-10-28 | 1990-11-28 | Smith Kline & French Laboratories Limited | Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists |
GB8717374D0 (en) * | 1987-07-22 | 1987-08-26 | Smith Kline French Lab | Pharmaceutically active compounds |
EP1023269A4 (en) * | 1997-09-30 | 2001-06-27 | Molecular Design Int | Beta3-adrenoreceptor agonists, agonist compositions and methods of using |
US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
GB0210762D0 (en) * | 2002-05-10 | 2002-06-19 | Glaxo Group Ltd | Compounds |
US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE24763E (en) | 1960-01-12 | Ch ch j | ||
US3549640A (en) * | 1967-11-03 | 1970-12-22 | Mallinckrodt Chemical Works | N-alkylsulfinylalkyl- and sulfonylalkyl-1,2,3,4-tetrahydroisoquinolines |
GB1384530A (en) * | 1971-07-29 | 1975-02-19 | Fisons Ltd | Chromone derivatives |
AT352135B (en) * | 1975-07-30 | 1979-09-10 | Thomae Gmbh Dr K | Process for the preparation of new homophthalimides and their salts |
DE2734222A1 (en) * | 1977-07-29 | 1979-02-15 | Thomae Gmbh Dr K | NEW SULFURIZED ISOCHINOLINDIONES |
US4252818A (en) * | 1979-08-02 | 1981-02-24 | Merck & Co., Inc. | Novel benzopyran derivatives |
-
1980
- 1980-09-26 US US06/191,644 patent/US4321254A/en not_active Expired - Lifetime
-
1981
- 1981-09-23 DK DK420781A patent/DK420781A/en not_active Application Discontinuation
- 1981-09-23 GR GR66121A patent/GR75053B/el unknown
- 1981-09-24 JP JP56151345A patent/JPS5785370A/en active Pending
- 1981-09-25 IE IE2228/81A patent/IE51596B1/en unknown
- 1981-09-25 EP EP81304449A patent/EP0049135B1/en not_active Expired
- 1981-09-25 DE DE8181304449T patent/DE3163096D1/en not_active Expired
- 1981-09-25 AT AT81304449T patent/ATE7024T1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE7024T1 (en) | 1984-04-15 |
DK420781A (en) | 1982-03-27 |
EP0049135B1 (en) | 1984-04-11 |
US4321254A (en) | 1982-03-23 |
JPS5785370A (en) | 1982-05-28 |
IE812228L (en) | 1982-03-26 |
EP0049135A1 (en) | 1982-04-07 |
DE3163096D1 (en) | 1984-05-17 |
IE51596B1 (en) | 1987-01-21 |
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