GR35150B - PERFECTIONS IN OR IN RELATION TO THE METHOD OF ANTIBIOTICS. - Google Patents

PERFECTIONS IN OR IN RELATION TO THE METHOD OF ANTIBIOTICS.

Info

Publication number
GR35150B
GR35150B GR670135150A GR670135150A GR35150B GR 35150 B GR35150 B GR 35150B GR 670135150 A GR670135150 A GR 670135150A GR 670135150 A GR670135150 A GR 670135150A GR 35150 B GR35150 B GR 35150B
Authority
GR
Greece
Prior art keywords
reaction
salt
acid
acid addition
acylamidocef
Prior art date
Application number
GR670135150A
Other languages
Greek (el)
Original Assignee
Glaxo Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Limited filed Critical Glaxo Laboratories Limited
Publication of GR35150B publication Critical patent/GR35150B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

ία μέθοδος δια την παραγωγήν ενός Ν-(7-ακυλαμιδοκεφ-3-εμ-3-υλ-μεθυλ)πυριδινίου-4-καρβοξυλικού η οποία περιλαμβάνει τας εξής βαθμίδας: Α) την αντίδρασιν ενός 7-ακυλαμιδοκεφαλοσπορανικού οξέος ή ενός άλατος τούτου μετά πυριδίνης εν διαλύσει εντός ενόςμέσου της αντιδράσεως με παρουσίαν μιας τουλάχιστον ισομοριακής αναλογίας, υπολογιζομένης με βάσιν το 7-ακυλαμιδοκεφαλοσπορανικόν οξυ, θειοκυανιούχωνή ιωδιούχων ιόντων και την ανάκτησιν του παραγομένου Ν-(7-ακυλαμιδοκεφ-3-εμ-3-υλ-μεθυλ)πυριδινίου-4-καρβοξυλικού υπό την μορφήν του ακαθάρτου υδροθειοκυανιούχου ή υδροϊωδιούχου άλατος της προσθήκης οξέοΒ) μετατροπήν του ακαθάρου θειοκυανιούχυ ή υδροϊωδιούχου άλατος προσθήκης οξέος από το (Α) εις την μορφήν της βεταϊνης με αντίδρασιν του ειρημένου άλατος μετά μιας βάσεως με την βεταϊνην ανακτωμένην εντός μίας υδατίνης φάσεωC) την κατ'επιθυμίαν διοχέτευσιν της από το (Β) υδατίνης φάσεως δια μέσουενός ή περισσοτέρων ιόντο-ανταλλακτήρων και, αν επιθυμείται, ενός απορροφητικού αποχρωματιστικού δια την περαιτέρω αφαίρεσιν ακαθαρσιών, παραδ. χάρινοξίνων και βασικών ακαθαρσιών καθώς και χρωστικώνουσιώD) την αντίδρασιν της από του (Β) ή του (C) υδατίνης φάσεως μεθ'ενός οξέος δια τον σχηματισμόνενός αδιαλύτου άλατος προσθήκης οξέοΕ) τον διαχωρισμόν του άλατος προσθήκης οξέος του (D) από του μητρικού υγρού και την μετατροπήν του άλατος δις την μορφήν της βεταϊνης δι'αντιδράσεως μετά μίας βάσεω A process for the production of an N- (7-acylamidocef-3-em-3-yl-methyl) pyridinium-4-carboxylate comprising the following step: A) the reaction of a 7-acylamidocephalosporanic acid or a salt thereof with pyridine dissolved in a reaction medium in the presence of at least one equimolar ratio, calculated on the basis of the 7-acylamidocephalosporanic acid, the acylamidocef-3-em-3-yl-methyl) pyridinium-4-carboxylate in the form of crude hydrogen thiocyanate or hydrogen iodide of the acid addition B) conversion of the crude thiocyanate or Reaction of said salt after a base with betaine recovered in an aqueous phase; (c) the optional delivery of it from the (B) aqueous phase by means of one or more ion exchangers and, parad. harinoic and basic impurities as well as pigments D) the reaction of the (B) or (C) hydatine phase with an acid to form an insoluble acid addition salt E) the separation of the acid addition salt of the non- the conversion of the salt twice to the form of betaine by reaction on a base

GR670135150A 1966-04-07 1967-04-04 PERFECTIONS IN OR IN RELATION TO THE METHOD OF ANTIBIOTICS. GR35150B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1571966A GB1171603A (en) 1966-04-07 1966-04-07 Improvements in or relating to cephalosporins

Publications (1)

Publication Number Publication Date
GR35150B true GR35150B (en) 1968-08-21

Family

ID=10064258

Family Applications (1)

Application Number Title Priority Date Filing Date
GR670135150A GR35150B (en) 1966-04-07 1967-04-04 PERFECTIONS IN OR IN RELATION TO THE METHOD OF ANTIBIOTICS.

Country Status (10)

Country Link
AT (1) AT287189B (en)
BE (1) BE696775A (en)
CH (1) CH504472A (en)
DE (1) DE1695015C3 (en)
DK (1) DK136609C (en)
ES (1) ES339028A1 (en)
GB (1) GB1171603A (en)
GR (1) GR35150B (en)
NL (1) NL6704945A (en)
SE (1) SE370080B (en)

Also Published As

Publication number Publication date
DE1695015B2 (en) 1977-09-22
AT287189B (en) 1971-01-11
CH504472A (en) 1971-03-15
DK136609B (en) 1977-10-31
DE1695015C3 (en) 1978-05-03
NL6704945A (en) 1967-10-09
DE1695015A1 (en) 1972-03-09
SE370080B (en) 1974-09-30
GB1171603A (en) 1969-11-26
DK136609C (en) 1978-04-10
BE696775A (en) 1967-10-09
ES339028A1 (en) 1968-07-01

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