GR3023174T3 - Substituted heterocyclic carboxylic acid amides, their preparation, and their use as medicaments. - Google Patents
Substituted heterocyclic carboxylic acid amides, their preparation, and their use as medicaments.Info
- Publication number
- GR3023174T3 GR3023174T3 GR970400831T GR970400831T GR3023174T3 GR 3023174 T3 GR3023174 T3 GR 3023174T3 GR 970400831 T GR970400831 T GR 970400831T GR 970400831 T GR970400831 T GR 970400831T GR 3023174 T3 GR3023174 T3 GR 3023174T3
- Authority
- GR
- Greece
- Prior art keywords
- medicaments
- preparation
- carboxylic acid
- acid amides
- substituted heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention relates to compounds of the formula I <IMAGE> a process for their preparation, and their use as medicaments. In particular, the compounds are employed for the inhibition of collagen biosynthesis, as inhibitors of proline hydroxylase and as fibrosuppressants.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4337271A DE4337271A1 (en) | 1993-11-02 | 1993-11-02 | ubstd. heterocyclic carboxylic acid amides and their prepn. |
DE19944410881 DE4410881A1 (en) | 1994-03-29 | 1994-03-29 | Substd. heterocyclic carboxylic acid amides and their prepn. |
DE19944433928 DE4433928A1 (en) | 1994-09-23 | 1994-09-23 | Substd. heterocyclic carboxylic acid amides and their prepn. |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3023174T3 true GR3023174T3 (en) | 1997-07-30 |
Family
ID=27205714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR970400831T GR3023174T3 (en) | 1993-11-02 | 1997-04-18 | Substituted heterocyclic carboxylic acid amides, their preparation, and their use as medicaments. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0650961B1 (en) |
JP (1) | JPH07228571A (en) |
KR (1) | KR950014072A (en) |
CN (1) | CN1107145A (en) |
AT (1) | ATE149486T1 (en) |
AU (1) | AU676775B2 (en) |
CA (1) | CA2134866A1 (en) |
CY (1) | CY2120B1 (en) |
CZ (1) | CZ289356B6 (en) |
DE (1) | DE59401924D1 (en) |
DK (1) | DK0650961T3 (en) |
ES (1) | ES2101421T3 (en) |
GR (1) | GR3023174T3 (en) |
HK (1) | HK1006711A1 (en) |
IL (1) | IL111454A (en) |
MY (1) | MY112413A (en) |
NO (1) | NO301880B1 (en) |
NZ (1) | NZ264821A (en) |
PL (1) | PL179794B1 (en) |
TW (1) | TW399046B (en) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL135495A (en) * | 1995-09-28 | 2002-12-01 | Hoechst Ag | Intermediate compounds for the preparation of substituted quinoline-2-carboxylic acid amides |
DE19746287A1 (en) * | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituted isoquinoline-2-carboxylic acid amides, their preparation and their use as medicaments |
FR2803592A1 (en) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | NOVEL DERIVATIVES OF 3-HYDROXYPICOLINIC ACID, PROCESS FOR THEIR PREPARATION AND FUNGICIDAL COMPOSITIONS CONTAINING SAME |
EP1387838B1 (en) | 2001-05-08 | 2006-04-19 | Schering Aktiengesellschaft | Cyanoanthranilamide derivatives and the use thereof as medicaments |
DE10123573B4 (en) * | 2001-05-08 | 2005-06-02 | Schering Ag | N-Oxidanthranylamide derivatives and their use as pharmaceuticals |
DE10123587B4 (en) * | 2001-05-08 | 2005-04-07 | Schering Ag | Cyanoanthranylamide derivatives and their use as pharmaceuticals |
CN101664551B (en) * | 2001-12-06 | 2013-08-14 | 法布罗根股份有限公司 | Stabilization of hypoxia inducible factor (HIF) alpha |
EP2295060B1 (en) | 2001-12-06 | 2018-10-31 | Fibrogen, Inc. | Treatment or prevention of ischemic or hypoxic conditions |
US20030176317A1 (en) † | 2001-12-06 | 2003-09-18 | Volkmar Guenzler-Pukall | Stabilization of hypoxia inducible factor (HIF) alpha |
US7615565B2 (en) | 2002-07-31 | 2009-11-10 | Bayer Schering Pharma Aktiengesellschaft | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
CN102977015B (en) | 2003-06-06 | 2015-05-06 | 菲布罗根有限公司 | Nitrogen-containing heteroaryl compounds and their use in increasing endogeneous erythropoietin |
US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
EP1657241A1 (en) | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
EP1655295A1 (en) | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
US7906533B2 (en) | 2004-11-03 | 2011-03-15 | Bayer Schering Pharma Ag | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors |
ATE513833T1 (en) | 2005-03-02 | 2011-07-15 | Fibrogen Inc | THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF |
WO2006133391A2 (en) * | 2005-06-06 | 2006-12-14 | Fibrogen, Inc. | Improved treatment for anemia using a hif-alpha stabilising agent |
BRPI0611670A2 (en) | 2005-06-15 | 2016-11-16 | Fibrogen Inc | method for treating or preventing cancer in an individual |
MX2008009581A (en) | 2006-01-27 | 2009-01-07 | Fibrogen Inc | Cyanoisoquinoline compounds and methods of use thereof. |
BRPI0710527B8 (en) | 2006-04-04 | 2021-05-25 | Fibrogen Inc | pyrrolo- and thiazolo-pyridine compounds and pharmaceutical composition comprising them |
JP5113838B2 (en) | 2006-06-26 | 2013-01-09 | アケビア セラピューティックス, インコーポレイテッド | Prolyl hydroxylase inhibitors and methods of use |
US8962530B2 (en) | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
EP2188252B1 (en) * | 2007-09-20 | 2011-04-13 | Amgen Inc. | 1-(4-(4-benzylbenzamido)-benzyl)azetidine-3-carboxylic acid derivatives and related compounds as s1p receptor modulators for the treatment of immune disorders |
CN105037323A (en) | 2008-11-14 | 2015-11-11 | 菲布罗根有限公司 | Thiochromene derivatives as HIF hydroxylase inhibitors |
KR101007675B1 (en) * | 2010-08-13 | 2011-01-13 | 김병두 | Plasma spray gun with auxiliary cap and plasma spray system using the same |
KR101007674B1 (en) * | 2010-08-13 | 2011-01-13 | 김병두 | High velocity oxygen fuel spray gun with auxiliary cap and the spray system |
NO2686520T3 (en) | 2011-06-06 | 2018-03-17 | ||
AU2013229922B2 (en) | 2012-03-09 | 2017-09-28 | Fibrogen, Inc. | 4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors |
MA37825B1 (en) | 2012-07-04 | 2016-06-30 | Agro Kanesho Co Ltd | Derivative of 2-aminonicotinic acid ester and bactericidal containing it as active principle |
US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
BR112015001106B1 (en) | 2012-07-16 | 2021-11-09 | Fibrogen, Inc | METHODS FOR THE PRODUCTION OF ISOQUINOLINE COMPOUNDS |
PT2872488T (en) | 2012-07-16 | 2018-11-22 | Fibrogen Inc | Crystalline forms of a prolyl hydroxylase inhibitor |
KR102233081B1 (en) | 2013-01-24 | 2021-03-29 | 피브로겐, 인크. | Crystalline forms of 〔[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino〕-acetic acid |
PT3003284T (en) | 2013-06-06 | 2020-08-10 | Fibrogen Inc | Pharmaceutical formulations of a hif hydroxylase inhibitor |
RS65341B1 (en) | 2013-06-13 | 2024-04-30 | Akebia Therapeutics Inc | Compositions and methods for treating anemia |
MA39033A1 (en) | 2013-11-15 | 2017-11-30 | Akebia Therapeutics Inc | Solid forms of {[5- (3-chlorophenyl) -3-hydroxypyridine-2-carbonyl] amino} acetic acid, compositions and uses thereof |
WO2016118858A1 (en) | 2015-01-23 | 2016-07-28 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
CN106146395B (en) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3- hydroxypyridine compound, preparation method and its pharmaceutical applications |
PL3277270T3 (en) | 2015-04-01 | 2022-02-14 | Akebia Therapeutics, Inc. | Compositions and methods for treating anemia |
AR114886A1 (en) | 2018-05-09 | 2020-10-28 | Akebia Therapeutics Inc | PROCESS TO PREPARE 2 - [[5- (3-CHLOROPHENYL) -3-HYDROXYPYRIDIN-2-CARBONYL] AMINO] ACETIC ACID |
AU2019340173B2 (en) * | 2018-09-13 | 2024-02-08 | Kissei Pharmaceutical Co., Ltd. | Imidazopyridinone compound |
US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4015255A1 (en) | 1990-05-12 | 1991-11-14 | Hoechst Ag | OXALYL-AMINOSA-E-LEED DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICAMENT FOR INHIBITING THE PROLYL HYDROXYLASE |
EP0541042A1 (en) * | 1991-11-05 | 1993-05-12 | Hoechst Aktiengesellschaft | 2,4- and 2,5-pyridine-dicarboxylic acid derivatives, process for their preparation and their use |
WO1993018006A1 (en) * | 1992-03-11 | 1993-09-16 | Narhex Limited | Amine derivatives of oxo- and hydroxy-substitued hydrocarbons |
TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
-
1994
- 1994-10-27 DK DK94117018.5T patent/DK0650961T3/en active
- 1994-10-27 ES ES94117018T patent/ES2101421T3/en not_active Expired - Lifetime
- 1994-10-27 AT AT94117018T patent/ATE149486T1/en not_active IP Right Cessation
- 1994-10-27 DE DE59401924T patent/DE59401924D1/en not_active Expired - Fee Related
- 1994-10-27 EP EP94117018A patent/EP0650961B1/en not_active Expired - Lifetime
- 1994-10-28 PL PL94305646A patent/PL179794B1/en unknown
- 1994-10-30 IL IL11145494A patent/IL111454A/en not_active IP Right Cessation
- 1994-10-31 AU AU77564/94A patent/AU676775B2/en not_active Ceased
- 1994-10-31 NZ NZ264821A patent/NZ264821A/en unknown
- 1994-10-31 MY MYPI94002894A patent/MY112413A/en unknown
- 1994-11-01 CA CA002134866A patent/CA2134866A1/en not_active Abandoned
- 1994-11-01 CZ CZ19942683A patent/CZ289356B6/en not_active IP Right Cessation
- 1994-11-01 NO NO944162A patent/NO301880B1/en not_active IP Right Cessation
- 1994-11-02 CN CN94117623A patent/CN1107145A/en active Pending
- 1994-11-02 JP JP6292032A patent/JPH07228571A/en not_active Abandoned
- 1994-11-02 KR KR1019940028871A patent/KR950014072A/en not_active Application Discontinuation
- 1994-12-05 TW TW083111257A patent/TW399046B/en not_active IP Right Cessation
-
1997
- 1997-04-18 GR GR970400831T patent/GR3023174T3/en unknown
-
1998
- 1998-06-22 HK HK98105872A patent/HK1006711A1/en not_active IP Right Cessation
- 1998-09-29 CY CY9800039A patent/CY2120B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CZ289356B6 (en) | 2002-01-16 |
CN1107145A (en) | 1995-08-23 |
PL179794B1 (en) | 2000-10-31 |
EP0650961A1 (en) | 1995-05-03 |
KR950014072A (en) | 1995-06-15 |
CA2134866A1 (en) | 1995-05-03 |
IL111454A0 (en) | 1994-12-29 |
HK1006711A1 (en) | 1999-03-12 |
EP0650961B1 (en) | 1997-03-05 |
ES2101421T3 (en) | 1997-07-01 |
JPH07228571A (en) | 1995-08-29 |
TW399046B (en) | 2000-07-21 |
PL305646A1 (en) | 1995-05-15 |
DE59401924D1 (en) | 1997-04-10 |
NO944162L (en) | 1995-05-03 |
AU676775B2 (en) | 1997-03-20 |
DK0650961T3 (en) | 1997-09-15 |
NZ264821A (en) | 1997-02-24 |
NO301880B1 (en) | 1997-12-22 |
AU7756494A (en) | 1995-05-18 |
CZ268394A3 (en) | 1995-05-17 |
IL111454A (en) | 2001-08-08 |
ATE149486T1 (en) | 1997-03-15 |
CY2120B1 (en) | 2002-04-26 |
MY112413A (en) | 2001-06-30 |
NO944162D0 (en) | 1994-11-01 |
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