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Application filed by Sandoz A.G.filedCriticalSandoz A.G.
Priority to GR590123768ApriorityCriticalpatent/GR23768B/en
Publication of GR23768BpublicationCriticalpatent/GR23768B/en
έθοδος παρασκευής του 1-μεθυλο-λυσεργοξυ-1'-υδροξυ-βουτυλαμιδίου-2' του τύπου Ι:
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χαρακτηριζομένη εκ του ότι κατεργαζόμεθα λυσεργοξύ-1'-υδροξυ-βουτυλαμίδιον-2' του τύπου ΙΙ:
[*]
εντός υγράς αμμωνίας μετά αμιδίου των μετάλλων των αλκαλίων καιτο προκύπτον αλκαλικόν άλας φέρομεν εις αντίδρασιν μετάμεθυλιωδιδίου εντός του αυτού διαλυτικού μέσου.
Process for the preparation of 1-methyl-lysergoxy-1'-hydroxy-butylamide-2 'of formula I:
[*]
characterized in that lysergoxy-1'-hydroxy-butylamide-2 'of formula II is treated:
[*]
in liquid ammonia with an amide of the alkali metals and the resulting alkali salt was reacted with a methyl iodide in the same solvent.
Process for the transformation of substituted amides of l-isolysergic and l-lysergic acids into corresponding derivatives of d-isolysergic and l-lysergic acids