GR20050100526A - Απορυθμισμενα γονιδια και/ ή μεθοδοι στην φλεγμονωδη αρθριτιδα. - Google Patents

Απορυθμισμενα γονιδια και/ ή μεθοδοι στην φλεγμονωδη αρθριτιδα.

Info

Publication number
GR20050100526A
GR20050100526A GR20050100526A GR20050100526A GR20050100526A GR 20050100526 A GR20050100526 A GR 20050100526A GR 20050100526 A GR20050100526 A GR 20050100526A GR 20050100526 A GR20050100526 A GR 20050100526A GR 20050100526 A GR20050100526 A GR 20050100526A
Authority
GR
Greece
Prior art keywords
arthritis
deregelated
inflamatory
genes
processes
Prior art date
Application number
GR20050100526A
Other languages
English (en)
Inventor
Georgios Kollias
Vassilios Aidinis
Yoshishide Hayashizaki
Piero Carninci
Original Assignee
B.S.R.C. "Alexander Fleming"
Riken
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B.S.R.C. "Alexander Fleming", Riken filed Critical B.S.R.C. "Alexander Fleming"
Priority to GR20050100526A priority Critical patent/GR20050100526A/el
Priority to JP2008535987A priority patent/JP2009512429A/ja
Priority to EP06806493A priority patent/EP1941273A2/en
Priority to US12/090,999 priority patent/US20080311185A1/en
Priority to PCT/EP2006/010228 priority patent/WO2007045511A2/en
Publication of GR20050100526A publication Critical patent/GR20050100526A/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Pathology (AREA)
  • Animal Husbandry (AREA)

Abstract

Η εφεύρεση παρέχει μέσα και μεθόδους για προσδιορισμό κατά πόσο ένα δείγμα λαμβάνεται από ένα άτομοπου υποφέρει από φλεγμονώδη αρθρίτιδα ή από ένα άτομο σε κίνδυνο να υποφέρει από αυτήν, η αναφερθείσα δε μέθοδος περιλαμβάνει μέτρηση στο αναφερθέν δείγμα του επιπέδου έκφρασης τουλάχιστον ενός γονιδιακού προϊόντος ενός γονιδίου του πίνακα Α ή του πίνακα Β και σύγκριση του αναφερθέντος επιπέδου έκφρασης με μία τιμή αναφοράς. Περαιτέρω παρέχει έναζωϊκό μοντέλο μη-άνθρωπο που περιλαμβάνει έκφρασηενός γονιδίου του πίνακα Α ή του πίνακα Β όταν συγκρίνεται προς ένα ζώο αναφορά μη-άνθρωπο.
GR20050100526A 2005-10-19 2005-10-19 Απορυθμισμενα γονιδια και/ ή μεθοδοι στην φλεγμονωδη αρθριτιδα. GR20050100526A (el)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GR20050100526A GR20050100526A (el) 2005-10-19 2005-10-19 Απορυθμισμενα γονιδια και/ ή μεθοδοι στην φλεγμονωδη αρθριτιδα.
JP2008535987A JP2009512429A (ja) 2005-10-19 2006-10-19 炎症性関節炎における調節が解除された遺伝子及び／又はプロセス
EP06806493A EP1941273A2 (en) 2005-10-19 2006-10-19 Deregulated genes and/or processes in inflammatory arthritis
US12/090,999 US20080311185A1 (en) 2005-10-19 2006-10-19 Deregulated Genes and/or Processes in Inflammatory Arthritis
PCT/EP2006/010228 WO2007045511A2 (en) 2005-10-19 2006-10-19 Deregulated genes and/or processes in inflammatory arthritis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20050100526A GR20050100526A (el) 2005-10-19 2005-10-19 Απορυθμισμενα γονιδια και/ ή μεθοδοι στην φλεγμονωδη αρθριτιδα.

Publications (1)

Publication Number Publication Date
GR20050100526A true GR20050100526A (el) 2007-05-23

Family

ID=37962868

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20050100526A GR20050100526A (el) 2005-10-19 2005-10-19 Απορυθμισμενα γονιδια και/ ή μεθοδοι στην φλεγμονωδη αρθριτιδα.

Country Status (5)

Country Link
US (1) US20080311185A1 (el)
EP (1) EP1941273A2 (el)
JP (1) JP2009512429A (el)
GR (1) GR20050100526A (el)
WO (1) WO2007045511A2 (el)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7320200A (en) * 1999-09-22 2001-04-24 Hitoshi Kohsaka P21cip1 remedies for rheumatism
WO2001074853A2 (en) * 2000-04-03 2001-10-11 Massachusetts Institute Of Technology Methods and products for regulating cell motility
EP1414500A4 (en) * 2001-04-16 2005-01-12 Uab Research Foundation ACT AND REGULATION OF SYNOVIAL FIBROBLAST APOPTOSIS AT RA
CA2488224A1 (en) * 2003-04-03 2004-10-21 Alnylam Pharmaceuticals, Inc. Irna conjugates

Also Published As

Publication number Publication date
EP1941273A2 (en) 2008-07-09
JP2009512429A (ja) 2009-03-26
WO2007045511A3 (en) 2007-11-29
WO2007045511A2 (en) 2007-04-26
US20080311185A1 (en) 2008-12-18

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