GR20000100281A - Synthetic methods in the tre - Google Patents
Synthetic methods in the treInfo
- Publication number
- GR20000100281A GR20000100281A GR20000100281A GR2000100281A GR20000100281A GR 20000100281 A GR20000100281 A GR 20000100281A GR 20000100281 A GR20000100281 A GR 20000100281A GR 2000100281 A GR2000100281 A GR 2000100281A GR 20000100281 A GR20000100281 A GR 20000100281A
- Authority
- GR
- Greece
- Prior art keywords
- trt
- side chains
- conformational
- tre
- synthetic methods
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
conformational model for ANG II is described in which the side chains of residues 2,4,6,8 form a cluster. These side chains together with their conformational distances derived from NOE studies provide for the pharmacophoric groups of non-peptide Angiotensin Ii mimetics. A three step (tritylation/alkylation/hydrolysis) sequence is proposed for a regioselective, high yield synthesis of 1,5 disubstituted imidazoles as key intermediates. Suitable protection of tetrazole with Trt, Cl-Trt, Benzyl and derivatives with subsequent hydroxymethylation, provides for prodrug substances with high activity of ling duration for treating hypertension and cardiovascular diseases.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20000100281A GR20000100281A (en) | 2000-08-17 | 2000-08-17 | Synthetic methods in the tre |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20000100281A GR20000100281A (en) | 2000-08-17 | 2000-08-17 | Synthetic methods in the tre |
Publications (2)
Publication Number | Publication Date |
---|---|
GR1003887B GR1003887B (en) | 2002-05-09 |
GR20000100281A true GR20000100281A (en) | 2002-05-24 |
Family
ID=10944356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20000100281A GR20000100281A (en) | 2000-08-17 | 2000-08-17 | Synthetic methods in the tre |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR20000100281A (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264447A (en) * | 1992-09-01 | 1993-11-23 | Merck & Co., Inc. | Angiotensin II antagonist |
EP0573218A2 (en) * | 1992-06-02 | 1993-12-08 | Sankyo Company Limited | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use |
WO1994003435A1 (en) * | 1992-08-06 | 1994-02-17 | E.I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists |
EP0795326A1 (en) * | 1994-03-16 | 1997-09-17 | Sankyo Company Limited | Ocular tension depressant |
-
2000
- 2000-08-17 GR GR20000100281A patent/GR20000100281A/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0573218A2 (en) * | 1992-06-02 | 1993-12-08 | Sankyo Company Limited | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use |
WO1994003435A1 (en) * | 1992-08-06 | 1994-02-17 | E.I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists |
US5264447A (en) * | 1992-09-01 | 1993-11-23 | Merck & Co., Inc. | Angiotensin II antagonist |
EP0795326A1 (en) * | 1994-03-16 | 1997-09-17 | Sankyo Company Limited | Ocular tension depressant |
Also Published As
Publication number | Publication date |
---|---|
GR1003887B (en) | 2002-05-09 |
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