GR20000100281A - Synthetic methods in the tre - Google Patents

Synthetic methods in the tre

Info

Publication number
GR20000100281A
GR20000100281A GR20000100281A GR2000100281A GR20000100281A GR 20000100281 A GR20000100281 A GR 20000100281A GR 20000100281 A GR20000100281 A GR 20000100281A GR 2000100281 A GR2000100281 A GR 2000100281A GR 20000100281 A GR20000100281 A GR 20000100281A
Authority
GR
Greece
Prior art keywords
trt
side chains
conformational
tre
synthetic methods
Prior art date
Application number
GR20000100281A
Other languages
Greek (el)
Other versions
GR1003887B (en
Inventor
Ιωαννης Ματσουκας
Παναγιωτα Ρουμελιωτη
Original Assignee
Ιωαννης Ματσουκας
Παναγιωτα Ρουμελιωτη
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ιωαννης Ματσουκας, Παναγιωτα Ρουμελιωτη filed Critical Ιωαννης Ματσουκας
Priority to GR20000100281A priority Critical patent/GR20000100281A/en
Publication of GR1003887B publication Critical patent/GR1003887B/en
Publication of GR20000100281A publication Critical patent/GR20000100281A/en

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

conformational model for ANG II is described in which the side chains of residues 2,4,6,8 form a cluster. These side chains together with their conformational distances derived from NOE studies provide for the pharmacophoric groups of non-peptide Angiotensin Ii mimetics. A three step (tritylation/alkylation/hydrolysis) sequence is proposed for a regioselective, high yield synthesis of 1,5 disubstituted imidazoles as key intermediates. Suitable protection of tetrazole with Trt, Cl-Trt, Benzyl and derivatives with subsequent hydroxymethylation, provides for prodrug substances with high activity of ling duration for treating hypertension and cardiovascular diseases.
GR20000100281A 2000-08-17 2000-08-17 Synthetic methods in the tre GR20000100281A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20000100281A GR20000100281A (en) 2000-08-17 2000-08-17 Synthetic methods in the tre

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20000100281A GR20000100281A (en) 2000-08-17 2000-08-17 Synthetic methods in the tre

Publications (2)

Publication Number Publication Date
GR1003887B GR1003887B (en) 2002-05-09
GR20000100281A true GR20000100281A (en) 2002-05-24

Family

ID=10944356

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000100281A GR20000100281A (en) 2000-08-17 2000-08-17 Synthetic methods in the tre

Country Status (1)

Country Link
GR (1) GR20000100281A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264447A (en) * 1992-09-01 1993-11-23 Merck & Co., Inc. Angiotensin II antagonist
EP0573218A2 (en) * 1992-06-02 1993-12-08 Sankyo Company Limited 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use
WO1994003435A1 (en) * 1992-08-06 1994-02-17 E.I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists
EP0795326A1 (en) * 1994-03-16 1997-09-17 Sankyo Company Limited Ocular tension depressant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0573218A2 (en) * 1992-06-02 1993-12-08 Sankyo Company Limited 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use
WO1994003435A1 (en) * 1992-08-06 1994-02-17 E.I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin ii receptor antagonists
US5264447A (en) * 1992-09-01 1993-11-23 Merck & Co., Inc. Angiotensin II antagonist
EP0795326A1 (en) * 1994-03-16 1997-09-17 Sankyo Company Limited Ocular tension depressant

Also Published As

Publication number Publication date
GR1003887B (en) 2002-05-09

Similar Documents

Publication Publication Date Title
DE60313595D1 (en) IMPROVED SYNTHESIS OF CC-1065 ANALOGUE
EA200300387A1 (en) EP4 RECEPTOR INHIBITORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
TNSN07312A1 (en) Combination of organic compounds
WO2002002560A3 (en) Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv)
AR040014A1 (en) COMBINATION OF ORGANIC COMPOUNDS
PT1196414E (en) PRO-PHARMACONS OF IMPDH CARBAMATE INHIBITORS
NO20055863L (en) W-carboxyaryl-substituted diphenylurea compounds as raf kinase inhibitors
HK1089444A1 (en) Dihydropteridinones, method for the production and use thereof in the form of drugs
NO20050149L (en) Progress in treating ischemic reperfusion injury using adenosine receptor antagonists
ME00232B (en) Antibodies to opgl
DE60236102D1 (en) 1h-indolderivate als hochselektive cyclooxygenase-2-inhibitoren
BR0313293A (en) Organic compounds
AR055649A1 (en) COGNITIVE FUNCTION IMPROVEMENT METHOD
WO2001079561A3 (en) Alpha-2 adrenergic receptor polymorphisms
WO2006028867A3 (en) Diagnosis, prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling
WO2003106450A8 (en) Phenylaminopyrimidines and their use as rho-kinase inhibitors
WO2002036580A3 (en) Benzoxazole lpaat- beta inhibitors and uses thereof
AU2001256272A1 (en) Process for preparing substituted benzimidazole compounds
WO2005007175A3 (en) Cadherin directed molecular and cellular localization
ID24781A (en) PROCESS FOR PRODUCING PURIN NUCLEOTIDE
GR20000100281A (en) Synthetic methods in the tre
ATE397599T1 (en) PIPERIDINE DERIVATIVES SUITABLE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
NO20021425L (en) Process for reducing coking in cracking reactors
MXPA05008805A (en) Adenosine a1 receptor antagonist for the treatment of cardiac and renal diseases.
DE60003289D1 (en) COMBINATION THERAPY FOR LYMPHOPROLIFERATIVE DISEASES