GR1008332B - Nanocarrier compositions - Google Patents
Nanocarrier compositionsInfo
- Publication number
- GR1008332B GR1008332B GR20140100218A GR20140100218A GR1008332B GR 1008332 B GR1008332 B GR 1008332B GR 20140100218 A GR20140100218 A GR 20140100218A GR 20140100218 A GR20140100218 A GR 20140100218A GR 1008332 B GR1008332 B GR 1008332B
- Authority
- GR
- Greece
- Prior art keywords
- compositions
- tigapotide
- lipidic
- nanocarrier compositions
- dendrimeric
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000002539 nanocarrier Substances 0.000 title abstract 4
- ZRXXHPDJLAQCPC-SFJRRRFZSA-N tigapotide Chemical group C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@H](O)C)C(O)=O)NC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@@H](NC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=C(O)C=C1 ZRXXHPDJLAQCPC-SFJRRRFZSA-N 0.000 abstract 2
- 229950004301 tigapotide Drugs 0.000 abstract 2
- 108010093516 tigapotide Proteins 0.000 abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 238000000149 argon plasma sintering Methods 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000000084 colloidal system Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003068 static effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dispersion Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to novel compositions of tigapotide composed of polymeric, lipidic, dendrimeric and combined lipidic dendrimeric structures and their use in the treatment of disease. These nanocarrier compositions maximize the advantages of the drug delivery process of the novel colloid nanocarriers and consequently the biological properties (i. e. antitumoral) of tigapotide. Dynamic (DLS), static (SLS) and electrophoretic (ELS) light scattering were used to examine the size, the size distribution, the z-potential as well as the fractal dimension of the carriers in aqueous and biological media. The incorporation effectiveness of nanocarrier compositions was also studied.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20140100218A GR1008332B (en) | 2013-06-20 | 2013-06-20 | Nanocarrier compositions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20140100218A GR1008332B (en) | 2013-06-20 | 2013-06-20 | Nanocarrier compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1008332B true GR1008332B (en) | 2014-10-21 |
Family
ID=50792469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20140100218A GR1008332B (en) | 2013-06-20 | 2013-06-20 | Nanocarrier compositions |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR1008332B (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030170220A1 (en) * | 2000-10-16 | 2003-09-11 | Procyon Biopharma Inc. | Pharmaceutical preparations and methods for inhibiting tumors |
-
2013
- 2013-06-20 GR GR20140100218A patent/GR1008332B/en active IP Right Grant
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030170220A1 (en) * | 2000-10-16 | 2003-09-11 | Procyon Biopharma Inc. | Pharmaceutical preparations and methods for inhibiting tumors |
Non-Patent Citations (1)
Title |
---|
ROBERT E. HAWKINS ET AL: "Safety and Tolerability of PCK3145, a Synthetic Peptide Derived from Prostate Secretory Protein 94 (PSP94) in Metastatic Hormone-Refractory Prostate Cancer", CLINICAL PROSTATE CANCER, vol. 4, no. 2, September 2005 (2005-09-01), pages 91 - 99, XP055102417 * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PG | Patent granted |
Effective date: 20141121 |