GR1007882B - Functional multi-stimuli responsive polymeric nanocontainers-microcontainers as drug delivery systems - Google Patents

Functional multi-stimuli responsive polymeric nanocontainers-microcontainers as drug delivery systems

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Publication number
GR1007882B
GR1007882B GR20120100245A GR20120100245A GR1007882B GR 1007882 B GR1007882 B GR 1007882B GR 20120100245 A GR20120100245 A GR 20120100245A GR 20120100245 A GR20120100245 A GR 20120100245A GR 1007882 B GR1007882 B GR 1007882B
Authority
GR
Greece
Prior art keywords
nanocontainers
microcontainers
delivery systems
drug delivery
functional multi
Prior art date
Application number
GR20120100245A
Other languages
Greek (el)
Inventor
Γεωργιος Κωνσταντινου Κορδας
Ιωαννης Αλκιβιαδη Καρτσωνακης
Παναγιωτης Γεωργιου Μπιλαλης
Αικατερινη-Λητω Ελευθεριου Τσιβελεκα
Ελενη Κωνσταντινου Ευθυμιαδου
Χρηστος Γκολφινου Ταπεινος
Αλεξανδρος Βυρωνα Χατζηπαυλιδης
Original Assignee
Γεωργιος Κωνσταντινου Κορδας
Ιωαννης Αλκιβιαδη Καρτσωνακης
Παναγιωτης Γεωργιου Μπιλαλης
Αικατερινη-Λητω Ελευθεριου Τσιβελεκα
Ελενη Κωνσταντινου Ευθυμιαδου
Χρηστος Γκολφινου Ταπεινος
Αλεξανδρος Βυρωνα Χατζηπαυλιδης
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Γεωργιος Κωνσταντινου Κορδας, Ιωαννης Αλκιβιαδη Καρτσωνακης, Παναγιωτης Γεωργιου Μπιλαλης, Αικατερινη-Λητω Ελευθεριου Τσιβελεκα, Ελενη Κωνσταντινου Ευθυμιαδου, Χρηστος Γκολφινου Ταπεινος, Αλεξανδρος Βυρωνα Χατζηπαυλιδης filed Critical Γεωργιος Κωνσταντινου Κορδας
Priority to GR20120100245A priority Critical patent/GR1007882B/en
Publication of GR1007882B publication Critical patent/GR1007882B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0063—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use in a non-magnetic matrix, e.g. granular solids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Power Engineering (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

In this patent we describe the production of functional multi-stimuli responsive nanonontainers aiming to their use as drug delivery systems. Specifically, multiple pH; temperature and redox sensitive nanocontainers-microcontainers are described, fabricated through seed polymerization. Distillation-precipitation and emulsion polymerization methods, both subcategories of seed polymerization, have been also used for the preparation of the nanocontainers-microcontainers. The cores of the coreshell nanospheres have been prepared from a variety«, of polymers such as Poly(methacrylic acid) and Poly(methyl methacrylate) (organic cores) and SiO2 (Stober) (inorganic core). Once our nanocontainers-microcontainers fully evaluated according to their drug loading and release capacity and cytotoxicity, we are able to fine tune their properties in order to fabricate the ideal system. We succeed to develop an ideal combination of the above properties combined with a targeting group and magnetic nanoparticles aiming at gaining multiple stimuli response. Introducing tumor targeting groups onto polymeric surface, termed active targeting can further enhance their accumulation in cancer cells. This fuctionalization improves the biodistribution of the carried drugs significantly enhance the system`s therapeutic index and minimize the side effects.
GR20120100245A 2012-05-04 2012-05-04 Functional multi-stimuli responsive polymeric nanocontainers-microcontainers as drug delivery systems GR1007882B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20120100245A GR1007882B (en) 2012-05-04 2012-05-04 Functional multi-stimuli responsive polymeric nanocontainers-microcontainers as drug delivery systems

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20120100245A GR1007882B (en) 2012-05-04 2012-05-04 Functional multi-stimuli responsive polymeric nanocontainers-microcontainers as drug delivery systems

Publications (1)

Publication Number Publication Date
GR1007882B true GR1007882B (en) 2013-04-25

Family

ID=47501378

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20120100245A GR1007882B (en) 2012-05-04 2012-05-04 Functional multi-stimuli responsive polymeric nanocontainers-microcontainers as drug delivery systems

Country Status (1)

Country Link
GR (1) GR1007882B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109223730A (en) * 2018-10-01 2019-01-18 嘉兴德扬生物科技有限公司 A kind of multiple response targets the preparation method of mesoporous silicon substrate intelligence carrier

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051425A1 (en) * 1999-11-17 2006-03-09 Tagra Biotechnologies Ltd. Method of microencapsulation
WO2006051627A1 (en) * 2004-11-09 2006-05-18 National University Corporation Kanazawa University Core/shell type nanoparticles
WO2008048387A2 (en) * 2006-10-18 2008-04-24 Abbott Cardiovascular Systems Inc. Stimulus-release carrier, methods of manufacture and methods of treatment
WO2008095256A1 (en) * 2007-02-09 2008-08-14 Newsouth Innovations Pty Limited Hollow microparticles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060051425A1 (en) * 1999-11-17 2006-03-09 Tagra Biotechnologies Ltd. Method of microencapsulation
WO2006051627A1 (en) * 2004-11-09 2006-05-18 National University Corporation Kanazawa University Core/shell type nanoparticles
WO2008048387A2 (en) * 2006-10-18 2008-04-24 Abbott Cardiovascular Systems Inc. Stimulus-release carrier, methods of manufacture and methods of treatment
WO2008095256A1 (en) * 2007-02-09 2008-08-14 Newsouth Innovations Pty Limited Hollow microparticles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109223730A (en) * 2018-10-01 2019-01-18 嘉兴德扬生物科技有限公司 A kind of multiple response targets the preparation method of mesoporous silicon substrate intelligence carrier

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GR1007882B (en) Functional multi-stimuli responsive polymeric nanocontainers-microcontainers as drug delivery systems

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Effective date: 20130517