GR1007084B - 1,4-benzoxazine derivatives - Google Patents

Abstract

excitotoxic brain injury, metabolic brain injury, traumatic brain injury, spinal cord injury, and for the alleviation of benign forgetfulness and the memory impairement in connention with dementia syndromes and neurodegenerative diseases, in a subject in need thereof, by administering to the subject an effective amount of a compound of the invention, or its pharmaceutically acceptable salt or ester either alone or in combination with another medication along with a pharmaceutically acceptable excipient. In another embodiment the invention provides methods for providing neuroprotection, for inhibiting cell degeneration or cell death, for treatment or prophylaxis of a neurodegenerative disease, or for preventingthe neurotoxic effect of a compound including, but not limited to, excitatory amino acids such as glutamate or toxins, in a subject in need thereof, by administering to the subject an effective amount of a compound of the invention, or its pharmaceutically acceptable salt or ester either alone or in combination with another medication along with a pharmaceutically acceptable excipient. In another embodiment the invention provides methods for the treatment of infections with the parasite Toxoplasma gondii in a subject in need thereof, by administering to the subject an effective amount of a compound of the invention, or its pharmaceutically acceptable salt or ester either alone or in combination with another medication along with a pharmaceutically acceptable excipient. A better understanding of the invention will be obtained from the following detailed description of the article and the desired features, properties, characteristics and the relation of the elements as well as the process steps, or with respect to each of the others, as set forth and exemplified in the description and illustrative embodiments.