GR1006759B - Improved chemical synthesis of human relaxin - Google Patents

Improved chemical synthesis of human relaxin

Info

Publication number
GR1006759B
GR1006759B GR20080100815A GR20080100815A GR1006759B GR 1006759 B GR1006759 B GR 1006759B GR 20080100815 A GR20080100815 A GR 20080100815A GR 20080100815 A GR20080100815 A GR 20080100815A GR 1006759 B GR1006759 B GR 1006759B
Authority
GR
Greece
Prior art keywords
relaxin
chains
improved chemical
methionine
methionine sulfoxide
Prior art date
Application number
GR20080100815A
Other languages
Greek (el)
Inventor
Κλεομενης Μπαρλος
Δημητριος Γατος
Κωνσταντινος Μπαρλος
Original Assignee
Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras) filed Critical Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras)
Priority to GR20080100815A priority Critical patent/GR1006759B/en
Publication of GR1006759B publication Critical patent/GR1006759B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Abstract

In our invention are described improved chemical methods for producing the pharmaceutically active peptides Relaxin-1 and Relaxin-2 which are better suited as drug substances in comparison to recombinant derivatives. The key step of the syntheses isthe production of Relaxin B-chains containing methionine sulfoxide instead of methionine at position 24 for Relaxin 1 and at position 25 for Relaxin 2. That methionine sulfoxide containing B-chains are better soluble and allow the random combinationof the Relaxin A and B-chains to give methioninee sulfoxide containing Relaxin-1 and Relaxin-2 in high yield. The methionine sulfoxide containing Relaxin-1 and Relaxin-2 are reduced finally to the native Relaxin 1 and Relaxin 2 using ammonium iodideas the reducing agent.
GR20080100815A 2008-12-22 2008-12-22 Improved chemical synthesis of human relaxin GR1006759B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20080100815A GR1006759B (en) 2008-12-22 2008-12-22 Improved chemical synthesis of human relaxin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20080100815A GR1006759B (en) 2008-12-22 2008-12-22 Improved chemical synthesis of human relaxin

Publications (1)

Publication Number Publication Date
GR1006759B true GR1006759B (en) 2010-04-20

Family

ID=42245147

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20080100815A GR1006759B (en) 2008-12-22 2008-12-22 Improved chemical synthesis of human relaxin

Country Status (1)

Country Link
GR (1) GR1006759B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010140060A3 (en) * 2009-06-01 2011-05-19 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Relaxin peptide synthesis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656249A (en) * 1982-06-10 1987-04-07 Howard Florey Institute Of Experimental Physiology And Medicine Peptides with relaxin activity
EP0251615A2 (en) * 1986-06-23 1988-01-07 Genentech, Inc. Method of chain combination
US6200953B1 (en) * 1995-06-07 2001-03-13 Connetics Corporation Relaxin analogs and derivatives compositions
WO2004113381A1 (en) * 2003-06-20 2004-12-29 Howard Florey Institute Of Experimental Physiology And Medicine Relaxin superfamily peptide analogues

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656249A (en) * 1982-06-10 1987-04-07 Howard Florey Institute Of Experimental Physiology And Medicine Peptides with relaxin activity
EP0251615A2 (en) * 1986-06-23 1988-01-07 Genentech, Inc. Method of chain combination
US6200953B1 (en) * 1995-06-07 2001-03-13 Connetics Corporation Relaxin analogs and derivatives compositions
WO2004113381A1 (en) * 2003-06-20 2004-12-29 Howard Florey Institute Of Experimental Physiology And Medicine Relaxin superfamily peptide analogues

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010140060A3 (en) * 2009-06-01 2011-05-19 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Relaxin peptide synthesis
CN102647996A (en) * 2009-06-01 2012-08-22 帕特拉斯化学与生物制药实验室 Relaxin peptide synthesis
US8785384B2 (en) 2009-06-01 2014-07-22 Chemical & Biopharmaceutical Laboratories of Patras Peptide synthesis

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