GR1006492B - Cooperating induction of the apoptosis of prostatic tissue-prevention of prostate cancer - new treatment of peripheral androgenic blocking production of complex tablet. - Google Patents
Cooperating induction of the apoptosis of prostatic tissue-prevention of prostate cancer - new treatment of peripheral androgenic blocking production of complex tablet.Info
- Publication number
- GR1006492B GR1006492B GR20080100368A GR20080100368A GR1006492B GR 1006492 B GR1006492 B GR 1006492B GR 20080100368 A GR20080100368 A GR 20080100368A GR 20080100368 A GR20080100368 A GR 20080100368A GR 1006492 B GR1006492 B GR 1006492B
- Authority
- GR
- Greece
- Prior art keywords
- prostatic tissue
- apoptosis
- elimination
- prevention
- prostate cancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The induction of apoptosis, by terazosine hydrochloride acting on the elimination plateau of the prostatic tissue due to previous atrophy-degeneration by dutasteride or finasteride, allows the quicker, in short-term and long-term treatment, reduction of the prostatic tissue, in relation to dutasteride or finasteride. The prostate cancer is prevented in practice by the critical elimination of the time margin for the malignant growth or of the progress of an already existing, but undiagnosed one,which has not reached the limit of 110 cells [or the time limit of 8-10 years]. Furthermore, dysplastic-metaplastic cells are early eliminated, due to the activation of the production and subsequent destruction by P53, the apoptotic protein which selectively destroys any morphologically/functionally abnormal cell. With fenretinide, a drastic cooperative prophylaxis is provided, which is harmless for the prevention of cancer in the particular population groups mentioned in the description. The additional use of verapamil/diltiazem in this application field optimize the MDR elimination, the trapping of PgP170, and in practice save the patients to be treated.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20080100368A GR1006492B (en) | 2008-05-29 | 2008-05-29 | Cooperating induction of the apoptosis of prostatic tissue-prevention of prostate cancer - new treatment of peripheral androgenic blocking production of complex tablet. |
PCT/GR2009/000031 WO2009144514A2 (en) | 2008-05-29 | 2009-05-22 | Cooperative induction of apoptosis of prostate tissue - prostate cancer prevention - new practice of peripheral androgenic exclusion construction of complex tablet |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20080100368A GR1006492B (en) | 2008-05-29 | 2008-05-29 | Cooperating induction of the apoptosis of prostatic tissue-prevention of prostate cancer - new treatment of peripheral androgenic blocking production of complex tablet. |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1006492B true GR1006492B (en) | 2009-07-22 |
Family
ID=40888074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20080100368A GR1006492B (en) | 2008-05-29 | 2008-05-29 | Cooperating induction of the apoptosis of prostatic tissue-prevention of prostate cancer - new treatment of peripheral androgenic blocking production of complex tablet. |
Country Status (2)
Country | Link |
---|---|
GR (1) | GR1006492B (en) |
WO (1) | WO2009144514A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113122494B (en) * | 2021-04-25 | 2023-01-31 | 上海交通大学医学院附属第九人民医院 | Construction method of human prostate epithelial cell finasteride drug-resistant model |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ241979A (en) * | 1991-03-20 | 1996-01-26 | Merck & Co Inc | Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker |
-
2008
- 2008-05-29 GR GR20080100368A patent/GR1006492B/en not_active IP Right Cessation
-
2009
- 2009-05-22 WO PCT/GR2009/000031 patent/WO2009144514A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2009144514A2 (en) | 2009-12-03 |
WO2009144514A3 (en) | 2010-01-21 |
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Legal Events
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PG | Patent granted | ||
ML | Lapse due to non-payment of fees |