GR1005656B - Trityl-type polymer resin for solid phase peptide synthesis - Google Patents

Trityl-type polymer resin for solid phase peptide synthesis

Info

Publication number
GR1005656B
GR1005656B GR20060100374A GR20060100374A GR1005656B GR 1005656 B GR1005656 B GR 1005656B GR 20060100374 A GR20060100374 A GR 20060100374A GR 20060100374 A GR20060100374 A GR 20060100374A GR 1005656 B GR1005656 B GR 1005656B
Authority
GR
Greece
Prior art keywords
trityl
solid phase
phase peptide
peptide synthesis
polymer resin
Prior art date
Application number
GR20060100374A
Other languages
Greek (el)
Inventor
Χρηστος Ζηκος
Νικολαος Φερδεριγος
Original Assignee
Βιομεντικα Λαιφ Σαιενσις Ανωνυμη Εταιρια Φαρμακευτικων Προιοντων
Χρηστος Ζηκος
Νικολαος Φερδεριγος
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Βιομεντικα Λαιφ Σαιενσις Ανωνυμη Εταιρια Φαρμακευτικων Προιοντων, Χρηστος Ζηκος, Νικολαος Φερδεριγος filed Critical Βιομεντικα Λαιφ Σαιενσις Ανωνυμη Εταιρια Φαρμακευτικων Προιοντων
Priority to GR20060100374A priority Critical patent/GR1005656B/en
Publication of GR1005656B publication Critical patent/GR1005656B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

The present invention refers to the development of a novel, trityl-type divinyl-benzol- polystyrene copolymer resin, which bears a trifluoromethyl-group at a suitable position of the trityl-ring system. The new resin is of low cost, has excellent swelling properties in most of the solvents used in peptide (in general, in organic) synthesis and can be applied as a functionalized solid matrix to the solid phase peptide synthesis (in general, to the solid phase organic synthesis). The present invention refers also to the method of making the novel resin as well as in its use for the production of polypeptides.
GR20060100374A 2006-06-27 2006-06-27 Trityl-type polymer resin for solid phase peptide synthesis GR1005656B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20060100374A GR1005656B (en) 2006-06-27 2006-06-27 Trityl-type polymer resin for solid phase peptide synthesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20060100374A GR1005656B (en) 2006-06-27 2006-06-27 Trityl-type polymer resin for solid phase peptide synthesis

Publications (1)

Publication Number Publication Date
GR1005656B true GR1005656B (en) 2007-09-20

Family

ID=37649545

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20060100374A GR1005656B (en) 2006-06-27 2006-06-27 Trityl-type polymer resin for solid phase peptide synthesis

Country Status (1)

Country Link
GR (1) GR1005656B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6254703A (en) * 1985-09-04 1987-03-10 Kanegafuchi Chem Ind Co Ltd Organic polymer acting as lewis acid
US5563220A (en) * 1991-06-14 1996-10-08 Research & Diagnostic Antibodies Polymeric resin for peptide synthesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6254703A (en) * 1985-09-04 1987-03-10 Kanegafuchi Chem Ind Co Ltd Organic polymer acting as lewis acid
US5563220A (en) * 1991-06-14 1996-10-08 Research & Diagnostic Antibodies Polymeric resin for peptide synthesis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHOI, MATTHEW KWOK WAI ET AL: "An improved and general synthesis of monomers for incorporating trityl linker groups into polystyrene synthesis supports", TETRAHEDRON , 60(12), 2903-2907 CODEN: TETRAB; ISSN: 0040-4020, 2004, XP002417824 *
COHEN, B. J. ET AL: ""Wolf and Lamb" reactions equilibrium and kinetic effects in multipolymer systems", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 103(25), 7620-9 CODEN: JACSAT; ISSN: 0002-7863, 1981, XP002417825 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MUKOYAMA, MITSUAKI ET AL: "Trityl salts of polymers as catalysts", XP002418098, retrieved from STN Database accession no. 1987:497280 *

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Legal Events

Date Code Title Description
PG Patent granted
ML Lapse due to non-payment of fees

Effective date: 20110104