GR1004952B - New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna - Google Patents
New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dnaInfo
- Publication number
- GR1004952B GR1004952B GR20040100361A GR2004100361A GR1004952B GR 1004952 B GR1004952 B GR 1004952B GR 20040100361 A GR20040100361 A GR 20040100361A GR 2004100361 A GR2004100361 A GR 2004100361A GR 1004952 B GR1004952 B GR 1004952B
- Authority
- GR
- Greece
- Prior art keywords
- compaction
- dna
- synthesis
- methods
- guanidinoalkylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
Abstract
he inventio relates to new compounds of type hexakis(6-deoxy-6-NH(CH2)n-R1)-a-cyclodextrin and heptakis(6-deoxy-6-NH(CH2)n-R1)--cyclodextrin, and octakis(6-deoxy-6-NH(CH2)n-R1)--cyclodextrin, where n-2-6 when R1=Nh2 and n=0 when R1 = C(=NH)NH2 and n=2-6 when R1 = NH-C(=NH)Nh2 and their use in the compaction of DNA. The invention also relates to methods of synthesis of the above compounds.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20040100361A GR1004952B (en) | 2004-09-10 | 2004-09-10 | New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20040100361A GR1004952B (en) | 2004-09-10 | 2004-09-10 | New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1004952B true GR1004952B (en) | 2005-07-28 |
Family
ID=34897633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20040100361A GR1004952B (en) | 2004-09-10 | 2004-09-10 | New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR1004952B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1846006A2 (en) * | 2005-01-28 | 2007-10-24 | Pinnacle Pharmaceuticals, Inc. | Beta-cyclodextrin derivatives as antibacterial agents |
-
2004
- 2004-09-10 GR GR20040100361A patent/GR1004952B/en unknown
Non-Patent Citations (4)
Title |
---|
ASHTON P R ET AL: "AMINO ACID DERIVATIVES OF BETA-CYCLODEXTRIN", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 61, no. 3, 9 February 1996 (1996-02-09), pages 903 - 908, XP002039797, ISSN: 0022-3263 * |
COTNER E. S. ET AL.: "Phosphotyrosine binding by ammonium and guanidinium-modified cyclodextrins", J, ORG. CHEM., vol. 63, 1998, USA, pages 1737 - 1739, XP008047082 * |
POPIELARSKI S. R.: "Structural effect of carbohydrate-containing polycations on gene delivery.3.Cyclodextrin type and functionalization", BIOCONJUGATE CHEM., vol. 14, 22 March 2003 (2003-03-22), USA, pages 672 - 678, XP008047076 * |
VIZITIU ET AL: "Synthesis of Mono-facially Functionalized Cyclodextrins Bearing Amino Pendent Groups", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 62, no. 25, 1997, pages 8760 - 8766, XP002305929, ISSN: 0022-3263 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1846006A2 (en) * | 2005-01-28 | 2007-10-24 | Pinnacle Pharmaceuticals, Inc. | Beta-cyclodextrin derivatives as antibacterial agents |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RS20050810A (en) | 5,7-diaminopyrazolo(4,3-d)pyrimidines useful in the treatment of hypertension | |
UA84161C2 (en) | Microgel composition, process for the preparation and use thereof | |
WO2003008583A3 (en) | Novel compositions and methods for cancer | |
GEP20084550B (en) | Substituted morpholine compounds for the treatment of central nervous system disorders | |
PL1682530T3 (en) | Pyrrole substituted indoles as inhibitors of pai-1 | |
RS20060320A (en) | Substituted indazole-o-glucosides | |
SG130189A1 (en) | Substituted indole-o-glucosides | |
TNSN05254A1 (en) | Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics | |
UA87991C2 (en) | Substituted indole-o-glucosides | |
WO2004069152A3 (en) | Δ4,5 glycuronidase and uses thereof | |
IL195256A0 (en) | Compositions of r(+)and s(-)pramipexole and methods of using the same | |
TW200602076A (en) | O, O'-amidomalonate and N, O-amidomalonate platinum complexes | |
TW200503710A (en) | Novel compounds | |
JO2795B1 (en) | Immunoglobulines | |
DE502004002571D1 (en) | SUBSTITUTED 3-PYRROLIDIN INDOL DERIVATIVES | |
WO2005075412A3 (en) | Norbornane based cycloaliphatic compounds containing nitrile groups | |
MY139162A (en) | Novolak resins and rubber compositions comprising the same | |
MX2012004548A (en) | Novel compositions for preventing and/or treating degenerative disorders of the central nervous system. | |
WO2003045230A3 (en) | Novel compositions and methods for cancer | |
WO2003057146A3 (en) | Novel compositions and methods for cancer | |
WO2005000207A3 (en) | Pcdgf receptor antibodies and methods of use thereof | |
PL1776103T3 (en) | Ruthenium complexes for treating cancers | |
WO2003053224A3 (en) | Novel compositions and methods for cancer | |
WO2002024867A3 (en) | Novel compositions and methods for lymphoma and leukemia | |
GB0324210D0 (en) | Organic compounds |