GR1004952B - New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna - Google Patents

New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna

Info

Publication number
GR1004952B
GR1004952B GR20040100361A GR2004100361A GR1004952B GR 1004952 B GR1004952 B GR 1004952B GR 20040100361 A GR20040100361 A GR 20040100361A GR 2004100361 A GR2004100361 A GR 2004100361A GR 1004952 B GR1004952 B GR 1004952B
Authority
GR
Greece
Prior art keywords
compaction
dna
synthesis
methods
guanidinoalkylamino
Prior art date
Application number
GR20040100361A
Other languages
Greek (el)
Inventor
Ειρηνη Μαυριδου
Κωνσταντινα Γιαννακοπουλου
Κυριακη Ηλιαδου
Νικολαος Μουρτζης
Χρυση Αγγελιδου
Original Assignee
Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος"
Ειρηνη Μαυριδου
Κωνσταντινα Γιαννακοπουλου
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος", Ειρηνη Μαυριδου, Κωνσταντινα Γιαννακοπουλου filed Critical Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος"
Priority to GR20040100361A priority Critical patent/GR1004952B/en
Publication of GR1004952B publication Critical patent/GR1004952B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

he inventio relates to new compounds of type hexakis(6-deoxy-6-NH(CH2)n-R1)-a-cyclodextrin and heptakis(6-deoxy-6-NH(CH2)n-R1)--cyclodextrin, and octakis(6-deoxy-6-NH(CH2)n-R1)--cyclodextrin, where n-2-6 when R1=Nh2 and n=0 when R1 = C(=NH)NH2 and n=2-6 when R1 = NH-C(=NH)Nh2 and their use in the compaction of DNA. The invention also relates to methods of synthesis of the above compounds.
GR20040100361A 2004-09-10 2004-09-10 New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna GR1004952B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20040100361A GR1004952B (en) 2004-09-10 2004-09-10 New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20040100361A GR1004952B (en) 2004-09-10 2004-09-10 New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna

Publications (1)

Publication Number Publication Date
GR1004952B true GR1004952B (en) 2005-07-28

Family

ID=34897633

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20040100361A GR1004952B (en) 2004-09-10 2004-09-10 New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna

Country Status (1)

Country Link
GR (1) GR1004952B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1846006A2 (en) * 2005-01-28 2007-10-24 Pinnacle Pharmaceuticals, Inc. Beta-cyclodextrin derivatives as antibacterial agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ASHTON P R ET AL: "AMINO ACID DERIVATIVES OF BETA-CYCLODEXTRIN", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 61, no. 3, 9 February 1996 (1996-02-09), pages 903 - 908, XP002039797, ISSN: 0022-3263 *
COTNER E. S. ET AL.: "Phosphotyrosine binding by ammonium and guanidinium-modified cyclodextrins", J, ORG. CHEM., vol. 63, 1998, USA, pages 1737 - 1739, XP008047082 *
POPIELARSKI S. R.: "Structural effect of carbohydrate-containing polycations on gene delivery.3.Cyclodextrin type and functionalization", BIOCONJUGATE CHEM., vol. 14, 22 March 2003 (2003-03-22), USA, pages 672 - 678, XP008047076 *
VIZITIU ET AL: "Synthesis of Mono-facially Functionalized Cyclodextrins Bearing Amino Pendent Groups", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 62, no. 25, 1997, pages 8760 - 8766, XP002305929, ISSN: 0022-3263 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1846006A2 (en) * 2005-01-28 2007-10-24 Pinnacle Pharmaceuticals, Inc. Beta-cyclodextrin derivatives as antibacterial agents

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GR1004952B (en) New per-6-gaunidino-, -aminoalkylamino- and -guanidinoalkylamino-cyclodextrins, methods of their synthesis and their use for the compaction of dna