GR1004208B - Aminotetrahydrofuran derivatives, muscarinic/sigma/sodium channel ligands, with synergic sigma/muscarinic (neuroactivating) and sigma/sodium channel (neuroprotective) components, as prototypical activating - neuroprotectors and neuroregenerative drugs - Google Patents
Aminotetrahydrofuran derivatives, muscarinic/sigma/sodium channel ligands, with synergic sigma/muscarinic (neuroactivating) and sigma/sodium channel (neuroprotective) components, as prototypical activating - neuroprotectors and neuroregenerative drugsInfo
- Publication number
- GR1004208B GR1004208B GR20010100476A GR2001100476A GR1004208B GR 1004208 B GR1004208 B GR 1004208B GR 20010100476 A GR20010100476 A GR 20010100476A GR 2001100476 A GR2001100476 A GR 2001100476A GR 1004208 B GR1004208 B GR 1004208B
- Authority
- GR
- Greece
- Prior art keywords
- sigma
- muscarinic
- sodium channel
- derivatives
- neuroactivating
- Prior art date
Links
- 108010052164 Sodium Channels Proteins 0.000 title 2
- 102000018674 Sodium Channels Human genes 0.000 title 2
- 230000003551 muscarinic effect Effects 0.000 title 2
- 230000003213 activating effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 230000000324 neuroprotective effect Effects 0.000 title 1
- 230000001067 neuroprotector Effects 0.000 title 1
- 230000003018 neuroregenerative effect Effects 0.000 title 1
- KQOATKAFTRNONV-UHFFFAOYSA-N oxolan-2-amine Chemical class NC1CCCO1 KQOATKAFTRNONV-UHFFFAOYSA-N 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
he invention relates to the amonitetrahydrofuran derivatives analogues of a or
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR20010100476A GR1004208B (en) | 2001-10-15 | 2001-10-15 | Aminotetrahydrofuran derivatives, muscarinic/sigma/sodium channel ligands, with synergic sigma/muscarinic (neuroactivating) and sigma/sodium channel (neuroprotective) components, as prototypical activating - neuroprotectors and neuroregenerative drugs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR20010100476A GR1004208B (en) | 2001-10-15 | 2001-10-15 | Aminotetrahydrofuran derivatives, muscarinic/sigma/sodium channel ligands, with synergic sigma/muscarinic (neuroactivating) and sigma/sodium channel (neuroprotective) components, as prototypical activating - neuroprotectors and neuroregenerative drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR1004208B true GR1004208B (en) | 2003-04-04 |
Family
ID=29559706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20010100476A GR1004208B (en) | 2001-10-15 | 2001-10-15 | Aminotetrahydrofuran derivatives, muscarinic/sigma/sodium channel ligands, with synergic sigma/muscarinic (neuroactivating) and sigma/sodium channel (neuroprotective) components, as prototypical activating - neuroprotectors and neuroregenerative drugs |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR1004208B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008087458A2 (en) * | 2007-01-17 | 2008-07-24 | Alexandre Vamvakides | NEW SIGMA(σ)-RECEPTOR LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES OVER CELLULAR BIOCHEMICAL MECHANISMS, WITH NEUROPROTECTIVE, ANTI-CANCER, ANTI-METASTATIC AND ANTI-(CHRONIC) INFLAMMATORY ACTION |
| WO2010097641A1 (en) * | 2009-02-26 | 2010-09-02 | Alexandre Vamvakides | SIGMA(σ) RECEPTORS LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES, OVER CELLULAR MECHANISMS, EXHIBITING PROTOTYPICAL CYTOPROTECTIVE AND ALSO ANTICANCER ACTIVITY |
| WO2017132127A1 (en) * | 2016-01-26 | 2017-08-03 | Anavex Life Sciences Corp. | Neurodevelopmental disorder therapy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997030983A1 (en) * | 1996-02-21 | 1997-08-28 | Alexandre Vamvakides | Tetrahydro-n,n-dimethyl-2,2-diphenyl-3-feranemethanamine, its enantiomers, and their pharmaceutically acceptable acid addition salts |
-
2001
- 2001-10-15 GR GR20010100476A patent/GR1004208B/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997030983A1 (en) * | 1996-02-21 | 1997-08-28 | Alexandre Vamvakides | Tetrahydro-n,n-dimethyl-2,2-diphenyl-3-feranemethanamine, its enantiomers, and their pharmaceutically acceptable acid addition salts |
Non-Patent Citations (8)
| Title |
|---|
| FOSCOLOS G B ET AL: "SYNTHESE ET ETUDE PHARMACOLOGIQUE DE QUELQUES AMINOLACTONES ET AMINOTETRAHYDROFURANES ADAMANTANIQUES", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 26, no. 1, 1991, pages 59 - 68, XP000915043, ISSN: 0223-5234 * |
| FOSCOLOS G B ET AL: "SYNTHESIS AND PHARMACOLOGICAL STUDY OF SOME NEW BETA-(DIALKYLAMINOMETHYL)-GAMMA-BUTYROLACTONES AND THEIR TETRAHYDROFURAN ANALOGUES", FARMACO, SOCIETA CHIMICA ITALIANA, PAVIA, IT, vol. 51, no. 1, 1996, pages 19 - 26, XP000915050, ISSN: 0014-827X * |
| KOLOCOURIS, NICOLAS M. ET AL.: "Synthesis and pharmacological study of spiropolycyclic lactone amino derivatives", CHEM. CHRON., vol. 15, no. 4, 1986, pages 185 - 192, XP008003695 * |
| KOLOKOURIS N ET AL: "NOUVEAUX AMINOETHERS ET AMINOLACTONES, SYNTHESE ET APPROCHE PHARMACOLOGIQUE NEW CYCLIC AMINOETHERS AND AMINOLECTONES, SYNTHESIS AND PHARMACOLOGICAL APPROACH", ANNALES PHARMACEUTIQUES FRANCAISES, MASSON, PARIS, FR, vol. 43, no. 3, 1985, pages 257 - 264, XP000607706, ISSN: 0003-4509 * |
| LEHMANN, J. ET AL.: "Lactones. XXII. Synthesis and reduction of .alpha.-(aminomethylene)-.delta.,.delta.-diphenyl-.delta.-valerolactones", ARCH. PHARM. (WEINHEIM, GER.), vol. 323, no. 2, 1990, pages 117 - 120, XP008003696 * |
| LEHMANN, J. ET AL: "Lactones. 6. Proton-histaminolytic, neurotropically spasmolytic, and centrally sedative .alpha.-aminomethyl-.gamma.,.gamma.-diaryl-.gamma.-lactones", ARCH. PHARM. (WEINHEIM, GER.), vol. 318, no. 9, 1985, pages 769 - 776, XP008003697 * |
| MCCOMBIE, STUART W. ET AL.: "Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c", BIOORG. MED. CHEM. LETT., vol. 3, no. 8, 1993, pages 1537 - 1542, XP008003693 * |
| VAMVAKIDES ET AL: "D-cycloserine is active on adult mice and inactive on aged mice, in the forced swim test", ANNALES PHARMACEUTIQUES FRANCAISES, MASSON, PARIS, FR, vol. 56, no. 5, 1998, pages 209 - 212, XP002105695, ISSN: 0003-4509 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008087458A2 (en) * | 2007-01-17 | 2008-07-24 | Alexandre Vamvakides | NEW SIGMA(σ)-RECEPTOR LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES OVER CELLULAR BIOCHEMICAL MECHANISMS, WITH NEUROPROTECTIVE, ANTI-CANCER, ANTI-METASTATIC AND ANTI-(CHRONIC) INFLAMMATORY ACTION |
| WO2008087458A3 (en) * | 2007-01-17 | 2008-12-11 | Alexandre Vamvakides | NEW SIGMA(σ)-RECEPTOR LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES OVER CELLULAR BIOCHEMICAL MECHANISMS, WITH NEUROPROTECTIVE, ANTI-CANCER, ANTI-METASTATIC AND ANTI-(CHRONIC) INFLAMMATORY ACTION |
| RU2497511C2 (en) * | 2007-01-17 | 2013-11-10 | Александр ВАМВАКИДЕС | New sigma (σ)-receptor ligands with antiapoptotic and/or proapoptotic properties in relation to biochemical mechanisms of cell, possessing neuroprotective, anticancer, antimetastatic and anti-inflammatory action in chronic inflammatory process |
| WO2010097641A1 (en) * | 2009-02-26 | 2010-09-02 | Alexandre Vamvakides | SIGMA(σ) RECEPTORS LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES, OVER CELLULAR MECHANISMS, EXHIBITING PROTOTYPICAL CYTOPROTECTIVE AND ALSO ANTICANCER ACTIVITY |
| US9180106B2 (en) | 2009-02-26 | 2015-11-10 | Anavex Life Sciences Corp. | Sigma receptors ligands with anti-apoptotic and/or pro-apoptotic properties, over cellular mechanisms, exhibiting prototypical cytoprotective and also anti-cancer activity |
| WO2017132127A1 (en) * | 2016-01-26 | 2017-08-03 | Anavex Life Sciences Corp. | Neurodevelopmental disorder therapy |
| US10507196B2 (en) | 2016-01-26 | 2019-12-17 | Anavex Life Sciences Corp. | Neurodevelopmental disorder therapy |
| US10888543B2 (en) | 2016-01-26 | 2021-01-12 | Anavex Life Sciences Corp. | Neurodevelopmental disorder therapy |
| US11446275B2 (en) | 2016-01-26 | 2022-09-20 | Anavex Life Sciences Corp. | Neurodevelopmental disorder therapy |
| EP4104831A1 (en) * | 2016-01-26 | 2022-12-21 | Anavex Life Sciences Corp. | A2-73 for treating angelman syndrome, williams syndrome smith-magenis syndrome and multiple sclerosis |
| US11839600B2 (en) | 2016-01-26 | 2023-12-12 | Anavex Life Sciences Corp. | Neurodevelopmental disorder therapy |
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