GR1003871B - Anti-mucelia pharmaceutical materials with a controlled yield; new, water soluble polymer derivatives of sorbic acid, nystatine and amphotericine b - Google Patents
Anti-mucelia pharmaceutical materials with a controlled yield; new, water soluble polymer derivatives of sorbic acid, nystatine and amphotericine bInfo
- Publication number
- GR1003871B GR1003871B GR20000100176A GR2000100176A GR1003871B GR 1003871 B GR1003871 B GR 1003871B GR 20000100176 A GR20000100176 A GR 20000100176A GR 2000100176 A GR2000100176 A GR 2000100176A GR 1003871 B GR1003871 B GR 1003871B
- Authority
- GR
- Greece
- Prior art keywords
- nystatine
- amphotericine
- complexes
- sorbic acid
- water soluble
- Prior art date
Links
Abstract
his invention concerns the method of production and the application of new water soluble polymer agents (complexes) of sorbic acid, Nystatine and amphotericine B. The composition of the above products is effected by their reaction with polyvinylpyrrolidone (PVP) of different molecular weights. The complexes of sorbic acid have the following chemical structure:[*]Complexes of nystatine, amphotericine B and azoles with PVP have the same chemical structure. The antimycosis activity of the complexes produced was certified in-vitro to potentially pathogenic (Fusarium oxysporum) as well as pathogenic for humans and animals nycetes (Aspergillus parasiticus, Penicillium viridicatum, Candida tropicalis and Candida albicans). It was observed that the biological activity is a function of their molecular weight and that activity increased as the molecular weight was reduced. Water solubility, biocompatibility and proven better biological activity relatively to the micromolecular substances are among the principal features of the polymer medicines.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20000100176A GR1003871B (en) | 2000-05-25 | 2000-05-25 | Anti-mucelia pharmaceutical materials with a controlled yield; new, water soluble polymer derivatives of sorbic acid, nystatine and amphotericine b |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20000100176A GR1003871B (en) | 2000-05-25 | 2000-05-25 | Anti-mucelia pharmaceutical materials with a controlled yield; new, water soluble polymer derivatives of sorbic acid, nystatine and amphotericine b |
Publications (2)
Publication Number | Publication Date |
---|---|
GR20000100176A GR20000100176A (en) | 2002-01-31 |
GR1003871B true GR1003871B (en) | 2002-04-19 |
Family
ID=10944279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20000100176A GR1003871B (en) | 2000-05-25 | 2000-05-25 | Anti-mucelia pharmaceutical materials with a controlled yield; new, water soluble polymer derivatives of sorbic acid, nystatine and amphotericine b |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR1003871B (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769013A (en) * | 1982-09-13 | 1988-09-06 | Hydromer, Inc. | Bio-effecting medical material and device |
WO1990015628A1 (en) * | 1989-06-14 | 1990-12-27 | Cetus Corporation | Polymer/antibiotic conjugate |
CA2044663A1 (en) * | 1990-07-12 | 1992-01-13 | Makoto Tanaka | Water-dispersible polyene antifungal complexes |
-
2000
- 2000-05-25 GR GR20000100176A patent/GR1003871B/en unknown
Also Published As
Publication number | Publication date |
---|---|
GR20000100176A (en) | 2002-01-31 |
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