GR1002276B - Novel treatment. - Google Patents

Abstract

A method of treatment and/or prophylaxis of anxiety and/or mani, and/or depression and/or the effects associated with withdrawal from substances of abuse, and/or disorders treatable and/or preventable with anticonvulsive agents, comprising administering to the sufferer in need therof an effective or prophylactic amount of a compound of formula (I) or pharmaceutically acceptable salt thereof : C H E M I C A L F O R M U L A wherein Y is N and R2 is hydrogen, or Y is C-R1 where : either one of R1 and r2 is hydrogen and the other is selected from the class of hydrogen, C3-8 cycloalkyl, C1-6 alkyl optionally interrupted by oxygen or substituted aminicarbonyl, c1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyloxy, C1-6 alkoxy, nitro, cyani, halo, trifluoromethyl, CF3S,or a group CF3-A-, where A is -CF2-, - CO-, -CH2- or CH(OH),trifluoromethoxy, C1-6 alkylsulphinyl, C1-6 alkoxysulphinyl, C1-6 alkoxysulphonyl, aryl, heteroaryl, arylcarbonyl,heteroarylcarbonyl, arylsulphinyl, heteroarylsulphinyl, arylsulphonyl, heteroarylsulphonyl in which any aromatic moiety is optionally substituted, C16- alkylcarbonylamino, C1-6 alkoxycarbonylamino, c1-6 alkyl- thiocarbonyl, C1-6 alkoxy-thiocarbonyl, C1-6 alkyl- thiocarbonyloxy, 1-mercapto C2-7 alkyl, formyl, or aminosulphinyl, aminosulphonyl or aminocaronyl, any amino moiety being optionally substituted by one or two C1-6 alkyl groups, or C1-6 alkylsulphinylamino, C1-6 alkylsulphonylamino, C1-6 alkoxysulphinylamino or C1-6 alkoxysulphonylamino, or ethylenyl terminall substituted by C1-6 alkylcarbonyl, nitro or cyano, or -C(C1-6 alkyl)NOH or - C(C1-6 alkyl)NNH2, or one of R1 and R2 is nitro, cyano or C1-3 alkylcarbonyl and the other is methoxy or amino optionally substituted by one or two c1-6 alkyl or by C2-7 alkanoyl; one of R3 and r4 is hydrogen or C1-4 alkyl and the other is C1-4 alkyl or R3 and R4 together are C2-5 polymethylene; R5is C1-6 alkylcarbonyloxy, benzoyloxy, ONO2, benzyloxy,phenyloxy or C1-6 alkoxy and R6 and R9 are hydrogen or R5 is hydroxy and R6 is hydrogen or C1-2 alkyl and R9 is hydrogen ; R7 is fluorophenyl ; R8 is hydrogen or C1-6 alkyl; the r8-N-CO-R7 group being trans to the R5 group; and X is oxygen or NR10 where r10 is hydrogen or C1-6 alkyl.