GR1001050B - Particular human immunoglobulin receiver of il-2 new type - Google Patents

Particular human immunoglobulin receiver of il-2 new type

Info

Publication number
GR1001050B
GR1001050B GR900100009A GR900100009A GR1001050B GR 1001050 B GR1001050 B GR 1001050B GR 900100009 A GR900100009 A GR 900100009A GR 900100009 A GR900100009 A GR 900100009A GR 1001050 B GR1001050 B GR 1001050B
Authority
GR
Greece
Prior art keywords
immunoglobulin
immunoglobulins
cdr
donor immunoglobulin
donor
Prior art date
Application number
GR900100009A
Other languages
Greek (el)
Other versions
GR900100009A (en
Inventor
Cary L Queen
Harold E Selick
Original Assignee
Protein Design Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Design Labs Inc filed Critical Protein Design Labs Inc
Publication of GR900100009A publication Critical patent/GR900100009A/en
Publication of GR1001050B publication Critical patent/GR1001050B/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Νέαι μέθοδοι προς κατασκευήν εξανθρωπισμένων ανοσοσφαιρινών εχόντων μία ή περισσοτέρας περιοχάς προσδιορισμού συμπληρωματικότητας (CDR's) εκ μιας δότειρος ανοσοσφαιρίνης και μίαν περιοχήν σκελετού εκ μιας ανθρωπείου ανοσοσφαιρίνης περιλαμβάνουσαι πρώτον σύγκρισιν του σκελετού ή της μεταβλητής περιοχής αλληλουχίας αμινοξέως της δοτείρος ανοσοσφαιρίνης προς τας αντιστοίχους αλληλουχίας εις μιαν συλλογήν αλύσεων ανθρωπείων ανοσοσφαιρινών, και επιλογήν ως ανθρωπείου ανοσοσφαιρίνης μιας εκ των πλέον ομολόγων αλληλουχιών εκ της συλλογής. Εκάστη εξανθρωπισθείσα άλυσις ανοσοσφαιρίνης ημπορεί να περιλαμβάνει περί τα 3 ή περισσότερα αμινοξέα εκ της δότειρος ανοσοσφαιρίνης επιπροσθέτως των CDR's, συνήθως τουλάχιστον μίαν των οποίων είναι αμέσως παραπλεύρως προς μίαν CDR εις την δοτείραν ανοσοσφαιρίνην. Αι βαρείαι και ελαφραί αλύσεις ημπορεί να κατασκευασθούν εκάστη δια της χρησιμοποιήσεως ενός οιουδήποτε ή απάντων των τριών κριτηρίων επιπροσθέτων θέσεων. Οταν αι ανοσοσφαιρίναι της παρούσης εφευρέσεως συνδυασθούν εις εν άθικτον αντίσωμα, αι εξανθρωπισθείσαι ανοσοσφαιρίναι της παρούσης εφευρέσεως θα είναι ουσιαστικώς μη ανοσογονικαί εις ανθρώπους και θα διατηρούν ουσιαστικώς την αυτήν χημικήν συγγένειαν ως η δοτείρ ανοσοσφαιρίνη προς το αντιγόνον, τοιούτον όπως μία πρωτείνη ή ετέρα σύνθεσις περιέχουσα εν επιτόπιον. ωNovel methods for making humanized immunoglobulins having one or more complementarity determining regions (CDR's) from a donor immunoglobulin and a backbone region from a human immunoglobulin comprising first comparing the backbone or variable amino acid sequence region of the donor immunoglobulin to sequence counterparts in a collection of chains human immunoglobulins, and selecting as human immunoglobulin one of the most homologous sequences from the collection. Each humanized immunoglobulin chain may include about 3 or more amino acids from the donor immunoglobulin in addition to the CDR's, usually at least one of which is immediately adjacent to a CDR in the donor immunoglobulin. The heavy and light chains can each be constructed using any or all of the three additional site criteria. When the immunoglobulins of the present invention are combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and will retain substantially the same chemical affinity as the donor immunoglobulin to the antigen, such as a protein or other composition comprising a on the spot. oh

GR900100009A 1990-01-09 1990-01-09 Particular human immunoglobulin receiver of il-2 new type GR1001050B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR90100009 1990-01-09

Publications (2)

Publication Number Publication Date
GR900100009A GR900100009A (en) 1992-06-25
GR1001050B true GR1001050B (en) 1993-04-28

Family

ID=10940035

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100009A GR1001050B (en) 1990-01-09 1990-01-09 Particular human immunoglobulin receiver of il-2 new type

Country Status (1)

Country Link
GR (1) GR1001050B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0362371A4 (en) * 1988-04-15 1990-10-24 Protein Design Labs, Inc. Il-2 receptor-specific chimeric antibodies
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same

Also Published As

Publication number Publication date
GR900100009A (en) 1992-06-25

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