GEP19991648B - Physiologically Active Polyethylene Glycol-Interferon-Alpha Conjugate, Method for its Production, Pharmaceutical Composition Having Immunomodulatory and Antiviral Activity - Google Patents
Physiologically Active Polyethylene Glycol-Interferon-Alpha Conjugate, Method for its Production, Pharmaceutical Composition Having Immunomodulatory and Antiviral ActivityInfo
- Publication number
- GEP19991648B GEP19991648B GEAP19973737A GEAP1997003737A GEP19991648B GE P19991648 B GEP19991648 B GE P19991648B GE AP19973737 A GEAP19973737 A GE AP19973737A GE AP1997003737 A GEAP1997003737 A GE AP1997003737A GE P19991648 B GEP19991648 B GE P19991648B
- Authority
- GE
- Georgia
- Prior art keywords
- interferon
- polyethylene glycol
- pharmaceutical composition
- conjugate
- physiologically active
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.Technical Result Production of physiologically active poly¬ethylene glycol-interferon alpha conjugate with improved antiproliferative properties, increase in immunomodulatory and antiviral activity of the pharmaceutical composition. 2. Essence Physiologically active polyethylene glycol-interferon-alpha conjugate represents the compounds of the general formula: wherein R and Rare independently lower alkyl; X is NH or O; n and n are integers having a sum of from 600 to 1500; and the average molecular weight of the polyethylene glycol units in said conjugate is from about 26.000 daltons to about 66.000 daltons which is obtained by covalenty linking polyethylene glycol to interferon-alpha at pH 8-9 of the reaction mixture at temperature 4C. Pharmaceutical composition having immuno¬modu¬latory and antiviral actifity comprises said conjugate in effective amount and therapeutically acceptable additive. 3. Field of Application Organic chemistry, pharmacology. 2 ind. cl., 4 Tables, 6 fig.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GEAP19973737A GEP19991648B (en) | 1997-05-05 | 1997-05-05 | Physiologically Active Polyethylene Glycol-Interferon-Alpha Conjugate, Method for its Production, Pharmaceutical Composition Having Immunomodulatory and Antiviral Activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GEAP19973737A GEP19991648B (en) | 1997-05-05 | 1997-05-05 | Physiologically Active Polyethylene Glycol-Interferon-Alpha Conjugate, Method for its Production, Pharmaceutical Composition Having Immunomodulatory and Antiviral Activity |
Publications (1)
Publication Number | Publication Date |
---|---|
GEP19991648B true GEP19991648B (en) | 1999-06-14 |
Family
ID=81926190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GEAP19973737A GEP19991648B (en) | 1997-05-05 | 1997-05-05 | Physiologically Active Polyethylene Glycol-Interferon-Alpha Conjugate, Method for its Production, Pharmaceutical Composition Having Immunomodulatory and Antiviral Activity |
Country Status (1)
Country | Link |
---|---|
GE (1) | GEP19991648B (en) |
-
1997
- 1997-05-05 GE GEAP19973737A patent/GEP19991648B/en unknown
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