GEP19970787B - Mixture of quinolinecarboxylic acid and boric acid anhydride as intermediate derivatives of piperazinyl-3-quinolincarboxylic acid with antibacterial activity - Google Patents

Mixture of quinolinecarboxylic acid and boric acid anhydride as intermediate derivatives of piperazinyl-3-quinolincarboxylic acid with antibacterial activity

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Publication number
GEP19970787B
GEP19970787B GEAP19931404A GEAP1993001404A GEP19970787B GE P19970787 B GEP19970787 B GE P19970787B GE AP19931404 A GEAP19931404 A GE AP19931404A GE AP1993001404 A GEAP1993001404 A GE AP1993001404A GE P19970787 B GEP19970787 B GE P19970787B
Authority
GE
Georgia
Prior art keywords
stands
general formula
halogen
carbon atoms
acid
Prior art date
Application number
GEAP19931404A
Inventor
Peter Ritli
Maria Balogh
Agnes Horvath
Lelle Vasvari
Geza Kereszturi
Istvan Hermecz
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU871504A external-priority patent/HU198728B/en
Priority claimed from HU873147A external-priority patent/HU200187B/en
Priority claimed from PCT/HU1988/000018 external-priority patent/WO1988007998A1/en
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of GEP19970787B publication Critical patent/GEP19970787B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to new quinoline-3-carboxylic acid anhydrides of general formula (I) (wherein R stands for cyclopropyl, a group of the general formula -CH2CR<5>R<6>r<7> (wherein R<5>, R<6> and R<7> stand for hydrogen or halogen), or phenyl optionally substituted by 1 or 2 halogen, R<1> and R<2> stand for halogen, or an aliphatic acyloxy group containing 2 to 6 carbon atoms optionally substituted by halogen, or an aromatic acyloxy group containing 7 to 11 carbon atoms, R<3> stands for chlorine or fluorine and R<4> stands for hydrogen or fluorine) and to the process for the preparation thereof which comprises reacting a compound of general formula (II), (wherein R, R<3> and R<4> are the same as stated above, R<8> stands for hydrogen or alkyl containing 1 to 4 carbon atoms) with a compound of the formula (III): HBF4, or a borone derivative of the general formula (IV): BX3 (wherein X stands for fluorine, chlorine or bromine) or an ether complex thereof, or a triacyloxy borate derivative of the general formula (V): -B(OCOR<9>)3 (wherein R<9> stands for alkyl containing 1 to 5 carbon atoms optionally substituted by halogen, or aryl containing 6 to 10 carbon atoms). The compounds of general formula (I) are new intermediates for the preparation of known quinoline-3-carboxylic acids showing antibacterial activity.
GEAP19931404A 1987-04-08 1993-08-12 Mixture of quinolinecarboxylic acid and boric acid anhydride as intermediate derivatives of piperazinyl-3-quinolincarboxylic acid with antibacterial activity GEP19970787B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU871504A HU198728B (en) 1987-04-08 1987-04-08 Process for producing quinolinecarboxylic acid derivatives
HU873147A HU200187B (en) 1987-07-10 1987-07-10 Process for producing (1-substituted-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-boric) anhydrides
PCT/HU1988/000018 WO1988007998A1 (en) 1987-04-08 1988-04-08 Quinoline carboxylic acid boric acid anhydrides and process for the preparation thereof

Publications (1)

Publication Number Publication Date
GEP19970787B true GEP19970787B (en) 1997-01-20

Family

ID=26317375

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19931404A GEP19970787B (en) 1987-04-08 1993-08-12 Mixture of quinolinecarboxylic acid and boric acid anhydride as intermediate derivatives of piperazinyl-3-quinolincarboxylic acid with antibacterial activity

Country Status (3)

Country Link
GE (1) GEP19970787B (en)
RU (1) RU1804457C (en)
UA (1) UA19065A (en)

Also Published As

Publication number Publication date
RU1804457C (en) 1993-03-23
UA19065A (en) 1997-12-25

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