GEP19970787B - Mixture of quinolinecarboxylic acid and boric acid anhydride as intermediate derivatives of piperazinyl-3-quinolincarboxylic acid with antibacterial activity - Google Patents
Mixture of quinolinecarboxylic acid and boric acid anhydride as intermediate derivatives of piperazinyl-3-quinolincarboxylic acid with antibacterial activityInfo
- Publication number
- GEP19970787B GEP19970787B GEAP19931404A GEAP1993001404A GEP19970787B GE P19970787 B GEP19970787 B GE P19970787B GE AP19931404 A GEAP19931404 A GE AP19931404A GE AP1993001404 A GEAP1993001404 A GE AP1993001404A GE P19970787 B GEP19970787 B GE P19970787B
- Authority
- GE
- Georgia
- Prior art keywords
- stands
- general formula
- halogen
- carbon atoms
- acid
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to new quinoline-3-carboxylic acid anhydrides of general formula (I) (wherein R stands for cyclopropyl, a group of the general formula -CH2CR<5>R<6>r<7> (wherein R<5>, R<6> and R<7> stand for hydrogen or halogen), or phenyl optionally substituted by 1 or 2 halogen, R<1> and R<2> stand for halogen, or an aliphatic acyloxy group containing 2 to 6 carbon atoms optionally substituted by halogen, or an aromatic acyloxy group containing 7 to 11 carbon atoms, R<3> stands for chlorine or fluorine and R<4> stands for hydrogen or fluorine) and to the process for the preparation thereof which comprises reacting a compound of general formula (II), (wherein R, R<3> and R<4> are the same as stated above, R<8> stands for hydrogen or alkyl containing 1 to 4 carbon atoms) with a compound of the formula (III): HBF4, or a borone derivative of the general formula (IV): BX3 (wherein X stands for fluorine, chlorine or bromine) or an ether complex thereof, or a triacyloxy borate derivative of the general formula (V): -B(OCOR<9>)3 (wherein R<9> stands for alkyl containing 1 to 5 carbon atoms optionally substituted by halogen, or aryl containing 6 to 10 carbon atoms). The compounds of general formula (I) are new intermediates for the preparation of known quinoline-3-carboxylic acids showing antibacterial activity.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU871504A HU198728B (en) | 1987-04-08 | 1987-04-08 | Process for producing quinolinecarboxylic acid derivatives |
HU873147A HU200187B (en) | 1987-07-10 | 1987-07-10 | Process for producing (1-substituted-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-boric) anhydrides |
PCT/HU1988/000018 WO1988007998A1 (en) | 1987-04-08 | 1988-04-08 | Quinoline carboxylic acid boric acid anhydrides and process for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
GEP19970787B true GEP19970787B (en) | 1997-01-20 |
Family
ID=26317375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GEAP19931404A GEP19970787B (en) | 1987-04-08 | 1993-08-12 | Mixture of quinolinecarboxylic acid and boric acid anhydride as intermediate derivatives of piperazinyl-3-quinolincarboxylic acid with antibacterial activity |
Country Status (3)
Country | Link |
---|---|
GE (1) | GEP19970787B (en) |
RU (1) | RU1804457C (en) |
UA (1) | UA19065A (en) |
-
1988
- 1988-12-07 RU SU884613042A patent/RU1804457C/en active
- 1988-12-07 UA UA4613042A patent/UA19065A/en unknown
-
1993
- 1993-08-12 GE GEAP19931404A patent/GEP19970787B/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU1804457C (en) | 1993-03-23 |
UA19065A (en) | 1997-12-25 |
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