GB994614A - Trifluoromethyl chloranilide compounds - Google Patents

Trifluoromethyl chloranilide compounds

Info

Publication number
GB994614A
GB994614A GB47033/63A GB4703363A GB994614A GB 994614 A GB994614 A GB 994614A GB 47033/63 A GB47033/63 A GB 47033/63A GB 4703363 A GB4703363 A GB 4703363A GB 994614 A GB994614 A GB 994614A
Authority
GB
United Kingdom
Prior art keywords
trifluoromethyl
acid
chloroanilide
crotonic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB47033/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB994614A publication Critical patent/GB994614A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0004—Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of general formula <FORM:0994614/C2/1> in which R is hydrogen or methyl and R1 is n-butyl, cyclohexyl or benzyl; and their preparation by (1) reacting N-acrylic acid- or N - crotonic acid - 2 - trifluoromethyl - 4- chloro-anilide with n-butylamine, cyclohexylamine or benzylamine at elevated temperature; or (2) heating with at least two molar proportions of n - butylamine, cyclohexylamine or benzylamine an N - carboxylic acid - 2 - trifluoromethyl - 4 - chloroanilide which can be converted into the N-acrylic or crotonic acidderivative by heating with an amine. Acid addition salts are obtained. N - Crotonic acid - 2 - trifluoromethyl - 4-chloroanilide and N - (b -bromopropionic acid)-2 - trifluoromethyl - 4 - chloroanilide are prepared from the amine and acid chlorides.
GB47033/63A 1962-11-30 1963-11-28 Trifluoromethyl chloranilide compounds Expired GB994614A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF38431A DE1232159B (en) 1962-11-30 1962-11-30 Process for the preparation of beta-amino acid anilides containing trifluoromethyl groups

Publications (1)

Publication Number Publication Date
GB994614A true GB994614A (en) 1965-06-10

Family

ID=7097337

Family Applications (1)

Application Number Title Priority Date Filing Date
GB47033/63A Expired GB994614A (en) 1962-11-30 1963-11-28 Trifluoromethyl chloranilide compounds

Country Status (6)

Country Link
AT (1) AT244940B (en)
CH (1) CH428753A (en)
DE (1) DE1232159B (en)
FR (1) FR3258M (en)
GB (1) GB994614A (en)
SE (1) SE301644B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2177695A (en) * 1985-07-15 1987-01-28 Roussel Lab Ltd Aminoalkylamide derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH627446A5 (en) * 1978-01-17 1982-01-15 Debiopharm Sa NEW BENZAMIDE DERIVATIVES.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2177695A (en) * 1985-07-15 1987-01-28 Roussel Lab Ltd Aminoalkylamide derivatives
GB2177695B (en) * 1985-07-15 1989-07-19 Roussel Lab Ltd Aminoalkylamide derivatives

Also Published As

Publication number Publication date
SE301644B (en) 1968-06-17
CH428753A (en) 1967-01-31
DE1232159B (en) 1967-01-12
FR3258M (en) 1965-04-20
AT244940B (en) 1966-02-10

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