GB989951A - Anti-inflammatory pharmaceutical compositions containing n-phenyl anthranilic acid derivatives - Google Patents
Anti-inflammatory pharmaceutical compositions containing n-phenyl anthranilic acid derivativesInfo
- Publication number
- GB989951A GB989951A GB2272761A GB2272761A GB989951A GB 989951 A GB989951 A GB 989951A GB 2272761 A GB2272761 A GB 2272761A GB 2272761 A GB2272761 A GB 2272761A GB 989951 A GB989951 A GB 989951A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- group
- hydrogen
- halogen
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- ZWJINEZUASEZBH-UHFFFAOYSA-N fenamic acid Chemical class OC(=O)C1=CC=CC=C1NC1=CC=CC=C1 ZWJINEZUASEZBH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000005843 halogen group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- -1 o-halogenated benzoic acid compound Chemical class 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical class C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 150000002463 imidates Chemical class 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 abstract 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000003931 anilides Chemical class 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 150000005840 aryl radicals Chemical group 0.000 abstract 1
- IAHMNSCQDXESII-UHFFFAOYSA-N benzenecarboximidoyl chloride Chemical compound ClC(=N)C1=CC=CC=C1 IAHMNSCQDXESII-UHFFFAOYSA-N 0.000 abstract 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-O bis(2-hydroxyethyl)azanium Chemical compound OCC[NH2+]CCO ZBCBWPMODOFKDW-UHFFFAOYSA-O 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- 229960004544 cortisone Drugs 0.000 abstract 1
- JSYGRUBHOCKMGQ-UHFFFAOYSA-N dichloramine Chemical compound ClNCl JSYGRUBHOCKMGQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910052751 metal Chemical group 0.000 abstract 1
- 239000002184 metal Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 150000002989 phenols Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229960005205 prednisolone Drugs 0.000 abstract 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 1
- 229960004618 prednisone Drugs 0.000 abstract 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38097A US3138636A (en) | 1960-06-23 | 1960-06-23 | Anthranilic acid derivatives |
| US8218561A | 1961-01-12 | 1961-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB989951A true GB989951A (en) | 1965-04-22 |
Family
ID=26714852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2272761A Expired GB989951A (en) | 1960-06-23 | 1961-06-22 | Anti-inflammatory pharmaceutical compositions containing n-phenyl anthranilic acid derivatives |
Country Status (3)
| Country | Link |
|---|---|
| BE (2) | BE605302A (enrdf_load_stackoverflow) |
| FR (9) | FR1250M (enrdf_load_stackoverflow) |
| GB (1) | GB989951A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0053379A1 (en) * | 1980-11-28 | 1982-06-09 | Chugai Seiyaku Kabushiki Kaisha | Anti-peptic ulcer agent |
| US5155110A (en) * | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
-
1961
- 1961-06-22 GB GB2272761A patent/GB989951A/en not_active Expired
- 1961-06-22 FR FR765794A patent/FR1250M/fr not_active Expired
- 1961-06-22 FR FR865795A patent/FR1251M/fr not_active Expired
- 1961-06-22 BE BE605302D patent/BE605302A/xx unknown
- 1961-06-22 FR FR865796A patent/FR1416M/fr not_active Expired
- 1961-06-22 FR FR865797A patent/FR1252M/fr not_active Expired
- 1961-06-22 FR FR865793A patent/FR1249M/fr not_active Expired
- 1961-06-22 BE BE605303D patent/BE605303A/xx unknown
- 1961-09-21 FR FR873839A patent/FR1381M/fr not_active Expired
- 1961-09-21 FR FR873838A patent/FR1380M/fr not_active Expired
- 1961-09-21 FR FR873840A patent/FR1382M/fr not_active Expired
- 1961-09-21 FR FR873837A patent/FR1379M/fr not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0053379A1 (en) * | 1980-11-28 | 1982-06-09 | Chugai Seiyaku Kabushiki Kaisha | Anti-peptic ulcer agent |
| US5155110A (en) * | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1249M (fr) | 1962-05-18 |
| FR1381M (fr) | 1962-08-03 |
| BE605302A (enrdf_load_stackoverflow) | 1961-10-16 |
| FR1379M (fr) | 1962-08-03 |
| FR1380M (fr) | 1962-08-03 |
| FR1250M (fr) | 1962-05-18 |
| FR1416M (fr) | 1962-08-31 |
| BE605303A (enrdf_load_stackoverflow) | 1961-10-16 |
| FR1382M (fr) | 1962-08-03 |
| FR1251M (fr) | 1962-05-18 |
| FR1252M (fr) | 1962-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES431056A1 (es) | Procedimiento para la preparacion de nuevos n- (metoximetil-furilmetil)-6, 7-benzomorfanos y -morfinanos. | |
| GB1254332A (en) | Amino acids and their derivatives and processes for preparing them | |
| GB1414047A (en) | Ursolic acid derivatives | |
| GB989951A (en) | Anti-inflammatory pharmaceutical compositions containing n-phenyl anthranilic acid derivatives | |
| IL58256A (en) | N-pyrrolyl-pyridazineamines,process for their manufacture and antihypertensive compositions containing them | |
| US3905997A (en) | 3-Aryl-5-oxo-2-pyrazoline-4-carboxanilides and process therefor | |
| AU553826B2 (en) | Benzopyran-6-yl ethane-carboxylic acid and derivatives | |
| ES469473A1 (es) | Un procedimiento para la preparacion de derivados de n-fenil-n-(4-piperidinil) amida | |
| GB1055221A (en) | Pyridobenzoxazepine derivatives | |
| PT73659B (en) | Ethenylimidazole derivatives with antimycotic activity processes for their preparation and pharmaceutical compositions containing them,intermediates useful in their preparation and a process for the preparation thereof | |
| GB1174673A (en) | Substituted Phenyl Acetamides, a Process for their Manufacture and Preparations Containing Them | |
| US3705920A (en) | Sulfonylphenylphosphonic acids | |
| GB1509689A (en) | Pyrano-quinoline carboxylic acids processes for their preparation and their use as pharmaceutical agents | |
| GB1463256A (en) | Dioxamic acid derivatives | |
| ES311285A1 (es) | Procedimiento de preparaciën de un nuevo derivado de la triazolona | |
| ES8104805A1 (es) | Un procedimiento para la preparacion de octahidro-1h-pirro- lo-(2,3g)isoquinolinas | |
| ES8104309A1 (es) | Procedimiento para preparar enaminas | |
| GB1436304A (en) | Pyridine and pyridine oxide derivatives and processes for their preparation | |
| GB1088224A (en) | Acetamidine derivatives | |
| ES432366A1 (es) | Procedimiento para la preparacion de compuestos metalorgani-cos a base de cobre. | |
| ES342806A1 (es) | Procedimiento para la preparacion de derivados de difenila-mina. | |
| GB1490666A (en) | Dioxamic acid derivatives | |
| MA18964A1 (fr) | 2-aminoalkyl-5-pyridinols,procede pour leur preparation,compositions pharmaceutiques contenant ces composes et leurs utilisations therapeutiques | |
| GB1508222A (en) | Derivatives of pyrazolopyridines | |
| GB1219847A (en) | Novel 3-amino-4-oxo-1h-4,5-dihydro-1,2,5-benzotriazepines, processes for their preparation, and compositions incorporating them |