GB957462A - Amino-substituted coumarins and processes for their preparation - Google Patents

Amino-substituted coumarins and processes for their preparation

Info

Publication number
GB957462A
GB957462A GB40256/61A GB4025661A GB957462A GB 957462 A GB957462 A GB 957462A GB 40256/61 A GB40256/61 A GB 40256/61A GB 4025661 A GB4025661 A GB 4025661A GB 957462 A GB957462 A GB 957462A
Authority
GB
United Kingdom
Prior art keywords
compound
carbon atoms
group
general formula
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40256/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1270260A external-priority patent/CH390275A/en
Priority claimed from CH1270360A external-priority patent/CH398637A/en
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of GB957462A publication Critical patent/GB957462A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula: <FORM:0957462/C2/1> (wherein R1 represents an alkyl radical of 1-6 carbon atoms or a phenyl or phenalkyl radical, R2 and R3 each represent a hydrogen or halogen atom, R4 represents a hydrogen atom, an alkyl radical of 1-6 carbon atoms or a dialkylaminoalkyl radical having 2-4 carbon atoms in the alkylene group and 1-4 carbon atoms in each alkyl group, and R5 represents a hydrogen atom or an alkyl group of 1-4 carbon atoms) and the mono-acid salts of the compounds in which R4 is a dialkylaminoalkyl group, and the preparation thereof by (a) reacting a compound of the general formula: <FORM:0957462/C2/2> (wherein Hal represents a chlorine or bromine atom) with a compound R4NHR5, or (b) heating a compound of the general formula: <FORM:0957462/C2/3> with a compound R4NHR5, or (c) in certain cases, reacting, in the presence of an aicd-binding agent, a compound of the general formula: <FORM:0957462/C2/4> with a reactive ester of a compound R41-OH (wherein R41 has the meanings given for R4, other than a hydrogen atom or a phenyl group), and in all cases, if desired, when R4 is a dialkylaminoalky group, converting the product into a mono-acid salt by reaction with an inorganic or organic acid. The products have analgesic, antiphlogistic and antipyretic activity.
GB40256/61A 1960-11-15 1961-11-10 Amino-substituted coumarins and processes for their preparation Expired GB957462A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1270260A CH390275A (en) 1960-11-15 1960-11-15 Process for the production of new coumarin derivatives
CH1270360A CH398637A (en) 1960-11-15 1960-11-15 Process for the production of new coumarin derivatives

Publications (1)

Publication Number Publication Date
GB957462A true GB957462A (en) 1964-05-06

Family

ID=25710760

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40256/61A Expired GB957462A (en) 1960-11-15 1961-11-10 Amino-substituted coumarins and processes for their preparation

Country Status (3)

Country Link
BE (1) BE610413A (en)
GB (1) GB957462A (en)
SE (1) SE317087B (en)

Also Published As

Publication number Publication date
BE610413A (en) 1962-05-16
SE317087B (en) 1969-11-10

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