GB953005A - Substituted n-phenylethyl-n-phenyl-piperazines - Google Patents

Substituted n-phenylethyl-n-phenyl-piperazines

Info

Publication number
GB953005A
GB953005A GB6874/61A GB687461A GB953005A GB 953005 A GB953005 A GB 953005A GB 6874/61 A GB6874/61 A GB 6874/61A GB 687461 A GB687461 A GB 687461A GB 953005 A GB953005 A GB 953005A
Authority
GB
United Kingdom
Prior art keywords
compound
amino
formula
acetylamino
piperazines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6874/61A
Inventor
Jacques Boissier
Roger Ratouis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Original Assignee
Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA filed Critical Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Priority to GB6874/61A priority Critical patent/GB953005A/en
Priority to FR887538A priority patent/FR1749M/en
Publication of GB953005A publication Critical patent/GB953005A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of general formula: <FORM:0953005/C2/1> in which R1 represents fluorine, bromine, hydroxy, amino, nitro, methylthio or acetylamino; and their acid addition salts; and their preparation (except when R1 is amino) by reacting a compound of formula: <FORM:0953005/C2/2> in which X represents halogen with a compound of formula: <FORM:0953005/C2/3> in the presence of an alkaline agent capable of combining with the hydrohalic acid liberated in the reaction; and preparation of the amino compound from the above-produced nitrocompound by catatytic hydrogenation in the presence of platinum oxide and of the acetylamino compound by subsequent acetylation. N-(2-fluorophenyl)-piperazine is prepared by heating the hydrochlorides of o -fluoroaniline and diethanolamine. Therapeutic compositions comprise the above piperazines and salts with pharmaceutically acceptable carriers or diluents. Oral, rectal and parenteral administration using solid and liquid vehicles is mentioned. The compounds are central depressants, hypotensors, anticonvulsives and barbiturate potentiators.
GB6874/61A 1961-02-24 1961-02-24 Substituted n-phenylethyl-n-phenyl-piperazines Expired GB953005A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB6874/61A GB953005A (en) 1961-02-24 1961-02-24 Substituted n-phenylethyl-n-phenyl-piperazines
FR887538A FR1749M (en) 1961-02-24 1962-02-09 New piperazine derivatives, usable in therapy.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6874/61A GB953005A (en) 1961-02-24 1961-02-24 Substituted n-phenylethyl-n-phenyl-piperazines

Publications (1)

Publication Number Publication Date
GB953005A true GB953005A (en) 1964-03-18

Family

ID=9822362

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6874/61A Expired GB953005A (en) 1961-02-24 1961-02-24 Substituted n-phenylethyl-n-phenyl-piperazines

Country Status (2)

Country Link
FR (1) FR1749M (en)
GB (1) GB953005A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668681A (en) * 1981-11-03 1987-05-26 Societe Cortial, S.A. 2-(4-Phenylpiperazinylethyl) anilines
WO2003045917A2 (en) * 2001-11-30 2003-06-05 F. Hoffmann-Laroche Ag Ccr-3 receptor antagonists vii

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668681A (en) * 1981-11-03 1987-05-26 Societe Cortial, S.A. 2-(4-Phenylpiperazinylethyl) anilines
WO2003045917A2 (en) * 2001-11-30 2003-06-05 F. Hoffmann-Laroche Ag Ccr-3 receptor antagonists vii
WO2003045917A3 (en) * 2001-11-30 2003-10-09 Hoffmann La Roche Ccr-3 receptor antagonists vii
US7019007B2 (en) 2001-11-30 2006-03-28 Syntex (U.S.A.) Llc CCR-3 receptor antagonists (I)

Also Published As

Publication number Publication date
FR1749M (en) 1963-03-25

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