GB948540A - Improvements in or relating to 1-aralkylcyclopropylamines - Google Patents
Improvements in or relating to 1-aralkylcyclopropylaminesInfo
- Publication number
- GB948540A GB948540A GB4528761A GB4528761A GB948540A GB 948540 A GB948540 A GB 948540A GB 4528761 A GB4528761 A GB 4528761A GB 4528761 A GB4528761 A GB 4528761A GB 948540 A GB948540 A GB 948540A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formylamino
- compounds
- carbobenzoxyamino
- carbethoxyamino
- monomethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of general formula: <FORM:0948540/C2/1> in which R is hydrogen, chlorine, bromine, methyl, methoxy, or trifluoromethyl, and Z is amino, monomethylamino, dimethylamino, carbobenzoxyamino, carbethoxyamino, formylamino, or b -hydroxyethylamino; and their nontoxic pharmaceutically acceptable acid addition salts: and the process as described in the examples, wherein is illustrated the reaction scheme and intermediates as follows: <FORM:0948540/C2/2> <FORM:0948540/C2/3> <FORM:0948540/C2/4> <FORM:0948540/C2/5> and also the formation of monomethylamino compounds by reduction of the isocyanate (N-methylation with methyl iodide of a benzylamine derivative or of a sodio formylamino derivative followed by refluxing in ethanol and acid hydrolysis respectively is also mentioned); dimethylation with formaldehyde/formic acid; reaction on the amine of benzyl and ethyl chloroformate to form the carbobenzoxyamino and carbethoxyamino compounds, of ethyl formate to form the formylamino compound, and of ethylene oxide (ethylene halohydrins also mentioned) to form the b -hydroxyethylamino compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9165261A | 1961-02-27 | 1961-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB948540A true GB948540A (en) | 1964-02-05 |
Family
ID=22228918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4528761A Expired GB948540A (en) | 1961-02-27 | 1961-12-18 | Improvements in or relating to 1-aralkylcyclopropylamines |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB948540A (en) |
-
1961
- 1961-12-18 GB GB4528761A patent/GB948540A/en not_active Expired
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