GB9420249D0 - Cytotoxic receptor ligand scaffolds - Google Patents

Cytotoxic receptor ligand scaffolds

Info

Publication number
GB9420249D0
GB9420249D0 GB9420249A GB9420249A GB9420249D0 GB 9420249 D0 GB9420249 D0 GB 9420249D0 GB 9420249 A GB9420249 A GB 9420249A GB 9420249 A GB9420249 A GB 9420249A GB 9420249 D0 GB9420249 D0 GB 9420249D0
Authority
GB
United Kingdom
Prior art keywords
receptor ligand
cytotoxic receptor
ligand scaffolds
scaffolds
cytotoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9420249A
Other versions
GB2282812A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB9420249D0 publication Critical patent/GB9420249D0/en
Publication of GB2282812A publication Critical patent/GB2282812A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
GB9420249A 1993-10-15 1994-10-07 Cytotoxic/receptor ligand conjugates linked via lysine radicals Withdrawn GB2282812A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13851693A 1993-10-15 1993-10-15

Publications (2)

Publication Number Publication Date
GB9420249D0 true GB9420249D0 (en) 1994-11-23
GB2282812A GB2282812A (en) 1995-04-19

Family

ID=22482370

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9420249A Withdrawn GB2282812A (en) 1993-10-15 1994-10-07 Cytotoxic/receptor ligand conjugates linked via lysine radicals

Country Status (1)

Country Link
GB (1) GB2282812A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0859624A1 (en) * 1995-10-27 1998-08-26 Merck & Co., Inc. GnRH/REDUCED PSEUDOMONAS EXOTOXIN CONJUGATES
WO1997015316A1 (en) * 1995-10-27 1997-05-01 Merck & Co., Inc. Conjugates of gonadotropin releasing hormone
WO2017219029A2 (en) 2016-06-17 2017-12-21 Magenta Therapeutics, Inc. Compositions and methods for the depletion of cd117+cells

Also Published As

Publication number Publication date
GB2282812A (en) 1995-04-19

Similar Documents

Publication Publication Date Title
ZA944513B (en) Sigma receptor ligands
HU9603525D0 (en) Vironectin receptor antagonists
GB9104117D0 (en) Melt system for spray-forming
HU913074D0 (en) Fibrinogenic receptor antagonists
AU3934895A (en) 5-ht2 receptor ligands
GB2285796B (en) Construction Machine
GB9207606D0 (en) Thermit
ZA965318B (en) Camptothecin beta-hydrolactone compounds
HUP9702220A3 (en) Urokinase receptor ligands
GB9324606D0 (en) Angiotensin-ii receptor blocking cycloakylbenzylimidazoles
GB9420249D0 (en) Cytotoxic receptor ligand scaffolds
GB2274870B (en) Scaffolding support
GB2254367B (en) Scaffold fitting
IL106287A0 (en) Receptor derivatives
GB2276414B (en) Scaffolding bracket
GB2239670B (en) Scaffolding fitting
ZA934873B (en) Receptor derivatives
GB9318105D0 (en) Receptor action
HU9302923D0 (en) Horizontal bridging forming unit
ZA931124B (en) Meeting cost monitor
GB9223769D0 (en) Receptor cloning
GB9212427D0 (en) Receptor cloning
GB9723206D0 (en) New cytotoxic pyridoacridine alkaloids
GB9226949D0 (en) Cytotoxic compounds-i
IL100184A0 (en) Interphone

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)