GB927699A - - Google Patents

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Publication number
GB927699A
GB927699A GB927699DA GB927699A GB 927699 A GB927699 A GB 927699A GB 927699D A GB927699D A GB 927699DA GB 927699 A GB927699 A GB 927699A
Authority
GB
United Kingdom
Prior art keywords
sulphapyrimidines
group
alkoxy
alkoxy group
nov
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Publication of GB927699A publication Critical patent/GB927699A/en
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

927,699. Sulphapyrimidines. F. HOFFMANN-LA ROCHE & CO. A.G. Nov. 18, 1960 [Nov. 18, 1959; Jan. 14, 1960], No. 39695/60. Class 2(3). The invention comprises sulphapyrimidines of the general formula (wherein R<SP>1</SP> is a hydrogen atom or an acyl group and R<SP>2</SP> is an alkylthio group containing up to six carbon atoms or an alkoxy group), and a process for the preparation of sulphapyrimidines of the general formula (wherein R<SP>3</SP> is a halogen atom or, when R<SP>2</SP> is an alkoxy group, an alkoxy group) by reacting a 2-R<SP>2</SP>-4,6-dihalopyrimidine with an alkali metal salt of sulphanilamide or an N-acyl derivative thereof and, if desired, hydrolysing the N<SP>1</SP>-acyl group (if present) in the product and, if desired, replacing the remaining halogeno substituent and any alkylthio group by alkoxy. 2-Methoxy-4.6-dihydroxypyrimicidine is prepared by treating O-methylurea chloride with sodium methoxide followed by dimethyl malonate, and is converted to 2-methoxy-4.6- dichloropyrimidine by treatment with phosphorus oxychloride in the presence of dimethylaniline.
GB927699D Active GB927699A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB927699T

Publications (1)

Publication Number Publication Date
GB927699A true GB927699A (en)

Family

ID=10728012

Family Applications (1)

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GB927699D Active GB927699A (en)

Country Status (2)

Country Link
GB (1) GB927699A (en)
MY (1) MY6400035A (en)

Also Published As

Publication number Publication date
MY6400035A (en) 1964-12-31

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