GB916803A - Vaccine for the protection of humans against trachoma - Google Patents

Vaccine for the protection of humans against trachoma

Info

Publication number
GB916803A
GB916803A GB2617/59A GB261759A GB916803A GB 916803 A GB916803 A GB 916803A GB 2617/59 A GB2617/59 A GB 2617/59A GB 261759 A GB261759 A GB 261759A GB 916803 A GB916803 A GB 916803A
Authority
GB
United Kingdom
Prior art keywords
virus
phosphate buffered
buffered saline
attenuated
embryos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2617/59A
Inventor
Leslie Harold Collier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Priority to GB2617/59A priority Critical patent/GB916803A/en
Publication of GB916803A publication Critical patent/GB916803A/en
Priority to OA50936A priority patent/OA00849A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/118—Chlamydiaceae, e.g. Chlamydia trachomatis or Chlamydia psittaci

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A vaccine for protection of humans against trachoma comprises purified virulent or attenuated living trachoma virus or inclusion blennorrhoea virus and an injectable pharmaceutical carrier or diluent. The attenuated virus is obtained by many passages through a host such as thick embryos, tissue cultures and animal hosts. It is preferred to cultivate the virulent or attenuated virus in thick embryos which are 6 to 8 days old at inoculation. The embryos are inoculated via the yolk sac with a suspension in saline of yolk sac infected with the virus and containing streptomycin to prevent bacterial infection and are incubated at 35 DEG C. until the yolk sac is rich in virus, any eggs dying within 72 hours of inoculation being rejected. Infected yolk sacs free from bacteria are homogenized with phosphate buffered saline and centrifuged at 200 G for 5 minutes to remove impurities. The supernatant is mixed with more phosphate buffered saline and centrifuged at 40 DEG C. and 12,000 G to deposit the virus. The process is repeated on the deposited virus to bring about further purification. The virus is resuspended in phosphate buffered saline and mixed with sterile aqueous gelatine to give a final concentration of 10% aqueous gelatine. When required for use, the freeze dried product is reconstituted with sterile pyrogen free water. The gelatin is used to inhibit denaturation of the virus during freeze drying and may be replaced by dextran. Specification 764,718 is referred to.
GB2617/59A 1959-01-23 1959-01-23 Vaccine for the protection of humans against trachoma Expired GB916803A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB2617/59A GB916803A (en) 1959-01-23 1959-01-23 Vaccine for the protection of humans against trachoma
OA50936A OA00849A (en) 1959-01-23 1964-12-19 A method of preparing a vaccine against trachoma.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2617/59A GB916803A (en) 1959-01-23 1959-01-23 Vaccine for the protection of humans against trachoma

Publications (1)

Publication Number Publication Date
GB916803A true GB916803A (en) 1963-01-30

Family

ID=9742717

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2617/59A Expired GB916803A (en) 1959-01-23 1959-01-23 Vaccine for the protection of humans against trachoma

Country Status (2)

Country Link
GB (1) GB916803A (en)
OA (1) OA00849A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328208A (en) * 1981-05-20 1982-05-04 Kurbanov Ildus A Vaccine against chlamydous infections of farm animals

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328208A (en) * 1981-05-20 1982-05-04 Kurbanov Ildus A Vaccine against chlamydous infections of farm animals

Also Published As

Publication number Publication date
OA00849A (en) 1967-11-15

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