GB901691A - N-substituted-dibenzo[b.f]azepines and their preparation - Google Patents

N-substituted-dibenzo[b.f]azepines and their preparation

Info

Publication number
GB901691A
GB901691A GB40482/58A GB4048258A GB901691A GB 901691 A GB901691 A GB 901691A GB 40482/58 A GB40482/58 A GB 40482/58A GB 4048258 A GB4048258 A GB 4048258A GB 901691 A GB901691 A GB 901691A
Authority
GB
United Kingdom
Prior art keywords
general formula
dihydroazepine
epoxypropyl
azepine
azepines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40482/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of GB901691A publication Critical patent/GB901691A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises dibenzo[b.f.]-azepine and -dihydroazepine derivatives of the general formula <FORM:0901691/IV (b)/1> (wherein X represents -CH = CH- or -CH2-CH2-, p each Y represents a hydrogen or halogen atom, R1 and R2 represent C1-4 alkyl radicals, R3 represents a hydrogen atom or a C1-4 alkyl radical, and alkylene represents a C2-4 alkylene radical, or <FORM:0901691/IV (b)/2> represents a piperazine ring substituted at the second nitrogen atom by a C1-4 alkyl radical) and their mono- and di-acid-addition salts and quaternary ammonium compounds, and the preparation thereof by reacting a 5-(21,31-epoxypropyl)-azepine or -dihydroazepine of the general formula <FORM:0901691/IV (b)/3> with a diamine of the formula <FORM:0901691/IV (b)/4> and, if desired, converting the product into a salt by treatment with an inorganic or organic acid or into a quaternary ammonium compound by reaction with a reactive ester of an aliphatic or araliphatic alcohol. The products have spasmolytic, anti-allergic and hypnotic activity. 5-(21,31-Epoxypropyl)-azepines and -dihydroazepines of the general formula (II) above are prepared by reacting the alkali metal compounds of the corresponding 5-unsubstituted compounds with epichlorhydrin. Reference has been directed by the Comptroller to Specification 820,476.
GB40482/58A 1957-12-20 1958-12-16 N-substituted-dibenzo[b.f]azepines and their preparation Expired GB901691A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH5402657A CH364266A (en) 1957-12-20 1957-12-20 Process for the preparation of new N-heterocyclic compounds

Publications (1)

Publication Number Publication Date
GB901691A true GB901691A (en) 1962-07-25

Family

ID=4519036

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40482/58A Expired GB901691A (en) 1957-12-20 1958-12-16 N-substituted-dibenzo[b.f]azepines and their preparation

Country Status (2)

Country Link
CH (1) CH364266A (en)
GB (1) GB901691A (en)

Also Published As

Publication number Publication date
CH364266A (en) 1962-09-15

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