GB898784A - Preparation of members of the tetracycline series - Google Patents
Preparation of members of the tetracycline seriesInfo
- Publication number
- GB898784A GB898784A GB6680/59A GB668059A GB898784A GB 898784 A GB898784 A GB 898784A GB 6680/59 A GB6680/59 A GB 6680/59A GB 668059 A GB668059 A GB 668059A GB 898784 A GB898784 A GB 898784A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tetracycline
- water
- nutrient medium
- hormodendrum
- deoxytetracycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
12a-Hydroxy-tetracyclines are prepared by treating 12a-deoxytetracycline in a nutrient medium containing an assimiliable source of carbon, nitrogen and mineral salts with one or more oxygenating strains of microorganisms of the class Fungi Imperfecti which are members of the order Moniliales, and fermenting under aerobic conditions. Specified species are Myrothecium roridum, Hormodendrum hordei, Hormodendrum pallidum, Curvularia lanata, Curvularia pallescens and Botrytis cinera. The nutrient media are such as are suitable for the production of tetracycline per se, e.g. (a) corn steep liquor, sucrose and calcium carbonate in water, (b) corn meal, hydrolysed casein, glucose, yeast extract, potassium monohydrogen phosphate and calcium carbonate in water. The 12a-deoxytetracycline is added to the nutrient medium in a finely divided form, as a suspension in water or as a solution in a water-miscible solvent such as acetone, propylene glycol or dimethylformamide. Alternatively, the fungus may be grown in the nutrient medium under aerobic conditions, the cells separated from the fermentation medium and the 12a-deoxy-tetracycline added to the cell free filtrate and aeration continued for sufficient time to effect the desired hydroxylation. The produced tetracycline may be recovered from the reaction mixture by processes in general use for the recovery of tetracycline per se, e.g. extraction with butanol at pH 8.5 to 8.6, concentration of butanol extract and precipitation by means of a nonsolvent such as petroleum ether. Specifications 775,115, 859,580 and 859,581 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71919158A | 1958-03-05 | 1958-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB898784A true GB898784A (en) | 1962-06-14 |
Family
ID=24889112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6680/59A Expired GB898784A (en) | 1958-03-05 | 1959-02-26 | Preparation of members of the tetracycline series |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE576299A (en) |
| ES (1) | ES247689A1 (en) |
| GB (1) | GB898784A (en) |
-
1959
- 1959-02-26 GB GB6680/59A patent/GB898784A/en not_active Expired
- 1959-03-03 BE BE576299A patent/BE576299A/en unknown
- 1959-03-04 ES ES0247689A patent/ES247689A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE576299A (en) | 1959-09-03 |
| ES247689A1 (en) | 1959-07-01 |
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