GB880276A - Improvements in or relating to oleaginous pharmaceutical compositions - Google Patents

Improvements in or relating to oleaginous pharmaceutical compositions

Info

Publication number
GB880276A
GB880276A GB14246/60A GB1424660A GB880276A GB 880276 A GB880276 A GB 880276A GB 14246/60 A GB14246/60 A GB 14246/60A GB 1424660 A GB1424660 A GB 1424660A GB 880276 A GB880276 A GB 880276A
Authority
GB
United Kingdom
Prior art keywords
oil
water
preferred
fatty acids
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14246/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB880276A publication Critical patent/GB880276A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oleaginous compositions for application to the skin comprise about 5 to 20% (by weight) of C12-20 fatty acids (stearic and palmitic preferred), about 10 to 30% of C12-20 unsaturated fatty acids (oleic and linoleic preferred), about 10 to 20% of glyceryl monostearate, about 15 to 20% of a fixed oil (a liquid mixture of di- and tri-glyceryl esters of higher fatty acids, corn oil being preferred), from about 2 to 10% of a wax (esters of C12-20 fatty acid esters with C12-20 fatty alcohols e.g. spermaceti, cetyl palmitate and cetyl oleate) about 2 to 5% of cholesterol, about 3 to 8% squalene and about 5 to 15% of petrolatum. The above composition may form the oil phase of a water-in-oil emulsion 1 part oil to about 1 to 19 parts water) and an oil-in-water emulsion (about 1 to 15 parts per cent water). Optional ingredients include polyhydric alcohols e.g. glycerin and propylene glycol, surfactants, anti-oxidants, preservatives, sunscreens, vitamins, antibiotics e.g. neomycin sulphate and anti - inflammatory agents e.g. hydrocortisone acetate and 6a -methyl - 9a - fluoro - 11b ,17a - dihydroxy - 1,4-pregnadiene-3,20-dione.
GB14246/60A 1959-05-29 1960-04-22 Improvements in or relating to oleaginous pharmaceutical compositions Expired GB880276A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US880276XA 1959-05-29 1959-05-29

Publications (1)

Publication Number Publication Date
GB880276A true GB880276A (en) 1961-10-18

Family

ID=22208838

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14246/60A Expired GB880276A (en) 1959-05-29 1960-04-22 Improvements in or relating to oleaginous pharmaceutical compositions

Country Status (2)

Country Link
DE (1) DE1106455B (en)
GB (1) GB880276A (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041772A2 (en) * 1980-05-15 1981-12-16 Green Cross Corporation Fat emulsion containing a steroid
GB2123292A (en) * 1982-07-07 1984-02-01 Schering Ag Topical corticoid-containing preparations
US4777034A (en) * 1982-04-01 1988-10-11 Olivier Georges R G Compositions for counteracting the degradations and inconvenience of perspiration
WO2000064503A1 (en) * 1999-04-23 2000-11-02 Kimberly-Clark Worldwide, Inc. Skin-friendly absorbent articles and compositions
WO2000064501A1 (en) * 1999-04-23 2000-11-02 Kimberly-Clark Worldwide, Inc. Skin-friendly absorbent articles and compositions
WO2002034305A2 (en) * 2000-10-20 2002-05-02 Kimberly-Clark Worldwide, Inc. Absorbent articles enhancing skin barrier function
US6440437B1 (en) 2000-01-24 2002-08-27 Kimberly-Clark Worldwide, Inc. Wet wipes having skin health benefits
US6475197B1 (en) 1999-08-24 2002-11-05 Kimberly-Clark Worldwide, Inc. Absorbent articles having skin health benefits
US6515029B1 (en) 1999-04-23 2003-02-04 Kimberly-Clark Worldwide, Inc. Absorbent article having a hydrophilic lotionized bodyside liner
US6534074B2 (en) 1999-08-24 2003-03-18 Kimberly-Clark Worldwide, Inc. Absorbent articles providing skin health benefits
US6689932B2 (en) 2000-12-22 2004-02-10 Kimberly-Clark Worldwide, Inc. Absorbent articles with simplified compositions having good stability
US6749860B2 (en) 2000-12-22 2004-06-15 Kimberly-Clark Worldwide, Inc. Absorbent articles with non-aqueous compositions containing botanicals
US6756520B1 (en) 2000-10-20 2004-06-29 Kimberly-Clark Worldwide, Inc. Hydrophilic compositions for use on absorbent articles to enhance skin barrier
US7771735B2 (en) 2000-12-22 2010-08-10 Kimberly-Clark Worldwide, Inc. Absorbent articles with compositions for reducing irritation response
WO2011051354A3 (en) * 2009-10-27 2012-03-01 Besins Healthcare Luxembourg Sarl Transdermal pharmaceutical compositions comprising active agents

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0041772A2 (en) * 1980-05-15 1981-12-16 Green Cross Corporation Fat emulsion containing a steroid
EP0041772A3 (en) * 1980-05-15 1982-06-30 The Green Cross Corporation Fat emulsion containing a steroid
US4777034A (en) * 1982-04-01 1988-10-11 Olivier Georges R G Compositions for counteracting the degradations and inconvenience of perspiration
GB2123292A (en) * 1982-07-07 1984-02-01 Schering Ag Topical corticoid-containing preparations
US6287581B1 (en) 1999-04-23 2001-09-11 Kimberly-Clark Worldwide, Inc. Absorbent articles providing skin health benefits
WO2000064501A1 (en) * 1999-04-23 2000-11-02 Kimberly-Clark Worldwide, Inc. Skin-friendly absorbent articles and compositions
US6515029B1 (en) 1999-04-23 2003-02-04 Kimberly-Clark Worldwide, Inc. Absorbent article having a hydrophilic lotionized bodyside liner
GB2363721A (en) * 1999-04-23 2002-01-09 Kimberly Clark Co Skin-friendly absorbent articles and compositions
GB2363721B (en) * 1999-04-23 2003-09-03 Kimberly Clark Co Skin-friendly absorbent articles and compositions
WO2000064503A1 (en) * 1999-04-23 2000-11-02 Kimberly-Clark Worldwide, Inc. Skin-friendly absorbent articles and compositions
US6534074B2 (en) 1999-08-24 2003-03-18 Kimberly-Clark Worldwide, Inc. Absorbent articles providing skin health benefits
US6475197B1 (en) 1999-08-24 2002-11-05 Kimberly-Clark Worldwide, Inc. Absorbent articles having skin health benefits
US6440437B1 (en) 2000-01-24 2002-08-27 Kimberly-Clark Worldwide, Inc. Wet wipes having skin health benefits
US6503526B1 (en) 2000-10-20 2003-01-07 Kimberly-Clark Worldwide, Inc. Absorbent articles enhancing skin barrier function
WO2002034305A3 (en) * 2000-10-20 2002-09-06 Kimberly Clark Co Absorbent articles enhancing skin barrier function
GB2383542A (en) * 2000-10-20 2003-07-02 Kimberly Clark Co Absorbent articles enhancing skin barrier function
WO2002034305A2 (en) * 2000-10-20 2002-05-02 Kimberly-Clark Worldwide, Inc. Absorbent articles enhancing skin barrier function
US6756520B1 (en) 2000-10-20 2004-06-29 Kimberly-Clark Worldwide, Inc. Hydrophilic compositions for use on absorbent articles to enhance skin barrier
GB2383542B (en) * 2000-10-20 2004-12-01 Kimberly Clark Co Absorbent articles enhancing skin barrier function
US6689932B2 (en) 2000-12-22 2004-02-10 Kimberly-Clark Worldwide, Inc. Absorbent articles with simplified compositions having good stability
US6749860B2 (en) 2000-12-22 2004-06-15 Kimberly-Clark Worldwide, Inc. Absorbent articles with non-aqueous compositions containing botanicals
US7771735B2 (en) 2000-12-22 2010-08-10 Kimberly-Clark Worldwide, Inc. Absorbent articles with compositions for reducing irritation response
WO2011051354A3 (en) * 2009-10-27 2012-03-01 Besins Healthcare Luxembourg Sarl Transdermal pharmaceutical compositions comprising active agents
EP3360575A1 (en) * 2009-10-27 2018-08-15 Besins Healthcare Luxembourg SARL Transdermal pharmaceutical compositions comprising active agents
US10080760B2 (en) 2009-10-27 2018-09-25 Besins Healthcare Luxembourg Sarl Transdermal pharmaceutical compositions comprising active agents
US11040043B2 (en) 2009-10-27 2021-06-22 Besins Healthcare Luxembourg Sarl Transdermal pharmaceutical compositions comprising active agents

Also Published As

Publication number Publication date
DE1106455B (en) 1961-05-10

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