GB879208A - Process for the manufacture of chloracetates and aminoacetates of saturated and unsaturated 21-hydroxy-pregnane compounds and acid addition products of the aminoacetates - Google Patents
Process for the manufacture of chloracetates and aminoacetates of saturated and unsaturated 21-hydroxy-pregnane compounds and acid addition products of the aminoacetatesInfo
- Publication number
- GB879208A GB879208A GB6977/58A GB697758A GB879208A GB 879208 A GB879208 A GB 879208A GB 6977/58 A GB6977/58 A GB 6977/58A GB 697758 A GB697758 A GB 697758A GB 879208 A GB879208 A GB 879208A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acetate
- hydroxy
- pregnane
- saturated
- unsaturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DBMUNIJZUYVPCQ-XFNFOBRPSA-N pregnan-21-ol Chemical class C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CCO)[C@@H]4[C@@H]3CCC21 DBMUNIJZUYVPCQ-XFNFOBRPSA-N 0.000 title abstract 6
- 229920006395 saturated elastomer Polymers 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical class NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title 2
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical class OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 6
- PNVPNXKRAUBJGW-UHFFFAOYSA-N (2-chloroacetyl) 2-chloroacetate Chemical compound ClCC(=O)OC(=O)CCl PNVPNXKRAUBJGW-UHFFFAOYSA-N 0.000 abstract 3
- USPYDUPOCUYHQL-KVHKMPIWSA-N 5alpha-dihydrodeoxycorticosterone Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CC[C@H]21 USPYDUPOCUYHQL-KVHKMPIWSA-N 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 3
- 150000003840 hydrochlorides Chemical class 0.000 abstract 3
- 229960000890 hydrocortisone Drugs 0.000 abstract 3
- 239000012442 inert solvent Substances 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- AAXVEMMRQDVLJB-BULBTXNYSA-N fludrocortisone Chemical compound O=C1CC[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 AAXVEMMRQDVLJB-BULBTXNYSA-N 0.000 abstract 2
- 229960005205 prednisolone Drugs 0.000 abstract 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 2
- HBXIVWIDGFQMNM-VNFDLHCISA-N (8s,9s,10s,13r,14s,17r)-17-(2-hydroxyethyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CCO)[C@@H]4[C@@H]3CCC21 HBXIVWIDGFQMNM-VNFDLHCISA-N 0.000 abstract 1
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 abstract 1
- -1 21-hydroxy-pregnane compound Chemical class 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE566473X | 1957-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB879208A true GB879208A (en) | 1961-10-04 |
Family
ID=6818888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6977/58A Expired GB879208A (en) | 1957-04-04 | 1958-03-04 | Process for the manufacture of chloracetates and aminoacetates of saturated and unsaturated 21-hydroxy-pregnane compounds and acid addition products of the aminoacetates |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE566473A (enrdf_load_stackoverflow) |
| GB (1) | GB879208A (enrdf_load_stackoverflow) |
-
1958
- 1958-03-04 GB GB6977/58A patent/GB879208A/en not_active Expired
- 1958-04-04 BE BE566473D patent/BE566473A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE566473A (enrdf_load_stackoverflow) | 1958-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US2838498A (en) | 6-fluoro-delta4-3-keto steroids and process for preparing same | |
| US2831003A (en) | Cycloborate esters of 16alpha, 17alpha-dihydroxy steroids | |
| GB879208A (en) | Process for the manufacture of chloracetates and aminoacetates of saturated and unsaturated 21-hydroxy-pregnane compounds and acid addition products of the aminoacetates | |
| US3225034A (en) | 2beta-amino-steroids | |
| US3084159A (en) | 3-enol ethers of 3-oxo-delta-6-aminomethyl steroids and process for preparing same | |
| US2867636A (en) | 6-methyl-9alpha, 21 difluoro-11 oxygenated 17alpha hydroxy-1, 4 pregnadiene-3, 20 dione steroid compounds | |
| US3127425A (en) | 6, 17alpha-disubstituted 9alpha, 11beta-dihalogeno derivatives of a-ring unsaturated pregnane 3, 20-diones | |
| US3064017A (en) | Preparation viii | |
| US3082224A (en) | Novel 16alpha-methyl-3, 5-pregnadienes and processes | |
| US3137712A (en) | 16alpha-chloro-1, 4-pregnadienes | |
| US3099654A (en) | Novel 9alpha-fluoro-delta1-corticosteroids and preparation thereof | |
| US3196149A (en) | New 16-substituted pregnenes | |
| US2928852A (en) | 6-methyl-17alpha, 21-dihydroxy-4, 9(11)-pregnadiene-3, 20-dione and the 21-esters thereof | |
| US3153644A (en) | 16alpha, 17alpha-(2-halo-1-di-lower-alkylamino-2-haloalkylidenedioxy)-steroids and process for the preparation thereof | |
| US2773072A (en) | Steroid hydrolysis | |
| US2963496A (en) | 9 alpha-halo-16-dehydro steroids of the pregnane series | |
| US3025312A (en) | 9alpha, 11beta-dichloro pregnanes | |
| US2891080A (en) | 14alpha-hydroxy-9alpha halo hydrocortisone and intermediates | |
| US3364241A (en) | Process for the production of 6alpha-fluoro-16alpha-halo pregnanes and the intermediates therefor | |
| US3102896A (en) | 4-methyl-17-alpha-hydroxy-progesterone and esters thereof | |
| US3702848A (en) | Process for the conversion of 3-enol ethers of 3-keto-delta**4-steroids unsubstituted at c4 and c6 to the corresponding 3 - keto - delta**4-6beta - (n-disubstituted)aminomethyl compounds | |
| US3153645A (en) | 17alpha, 21-(2-halo-1-di-lower-alkylamino-2-haloalkylidenedioxy)-steroids and process for the preparation thereof | |
| US3033854A (en) | New aminomethyl-steroids and process for their manufacture | |
| US3437675A (en) | 16-halo-9beta,10alpha-steroids of the pregnane series | |
| US3043855A (en) | 16-ethers of 16, 17-dihydroxy steroids of the pregnane series |