GB877031A - A process for the production of natural phospholipids and related substances - Google Patents

A process for the production of natural phospholipids and related substances

Info

Publication number
GB877031A
GB877031A GB21837/58A GB2183758A GB877031A GB 877031 A GB877031 A GB 877031A GB 21837/58 A GB21837/58 A GB 21837/58A GB 2183758 A GB2183758 A GB 2183758A GB 877031 A GB877031 A GB 877031A
Authority
GB
United Kingdom
Prior art keywords
phosphoric acid
choline ester
ester
fatty acids
essential
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21837/58A
Inventor
Ernst Dr Klenk
Hans Dr Eikermann
Gertrud Dr Reuter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIA GRIESHABER LAPPE
ROLFE LAPPE
WALTER LAPPE
Original Assignee
RIA GRIESHABER LAPPE
ROLFE LAPPE
WALTER LAPPE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RIA GRIESHABER LAPPE, ROLFE LAPPE, WALTER LAPPE filed Critical RIA GRIESHABER LAPPE
Publication of GB877031A publication Critical patent/GB877031A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/103—Extraction or purification by physical or chemical treatment of natural phosphatides; Preparation of compositions containing phosphatides of unknown structure
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin

Abstract

A natural phospholipid is obtained from soya bean crude lecithin by extracting the crude lecithin with acetone, extracting the residual ester mixture with alcohol, allowing the alcoholic solution to stand for several days to clarify it from suspended colloidal particles, removing the alcoholic solution containing, as predominantly the basic component, a choline ester of diglyceride phosphoric acid, and recovering the said phospholipid from the alcohol solution, all steps being carried out in the presence of an inert gas at a temperature not exceeding 35 DEG C. whilst excluding the presence of oxygen and light. The phospholipid obtained has a content of substantially 60% essential and other unsaturated fatty acids relative to the total fatty acid content. The clarified alcoholic solution containing the choline ester of diglyceride phosphoric ester may be distilled under vacuum with exclusion of light and oxygen and in the presence of an inert gas e.g. nitrogen or CO2 and the product may be further treated to complete the separation of cephalin by passing an alcoholic solution thereof of 2-3% concentration at a temperature not exceeding 35 DEG C. with the exclusion of light and oxygen and in the presence of an inert gas such as nitrogen through an absorption column containing an alcoholic slurry of a carbonate and/or oxide of one or more elements of the second, third or fourth group of the Periodic Table, preferably Al and/or Mg and/or Si and eluting the slurry with alcohol. On distillation of the alcoholic eluate under vacuum in the presence of an inert gas while excluding oxygen and light a chemically pure choline ester of diglyceride phosphoric acid is obtained which has a high content of essential fatty acids and is suitable for intravenous administration. The chemically pure choline ester may be treated with snake venom to form monoglyceride phosphoric acid choline esters, the treatment with snake venom being carried out in a solvent medium, e.g. peroxide-free ether, in which the monoglyceride phosphoric acid choline ester is insoluble and the fatty acids which are split off in the alpha position are soluble. The invention also includes (a) a phospholipid containing a choline ester of diglyceride phosphoric acid as the basic component and containing substantially 60% essential unsaturated fatty acids, (b) a substantially chemically pure cephalin-free choline ester of diglyceride phosphoric acid containing substantially 66-70% essential unsaturated fatty acids, and (c) a choline ester of monoglyceride phosphoric acid having substantially 28% essential unsaturated fatty acid content, the percentage-essential unsaturated fatty acid content being based in each case on the total fatty acid content and an example is given in which such products are obtained from crude soya bean phosphaltides.
GB21837/58A 1957-07-09 1958-07-08 A process for the production of natural phospholipids and related substances Expired GB877031A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEN13867A DE1047597B (en) 1957-07-09 1957-07-09 Process for the production of natural choline phosphoric acid diglyceride esters poor in colaminphosphoric acid diglyceride esters

Publications (1)

Publication Number Publication Date
GB877031A true GB877031A (en) 1961-09-13

Family

ID=7339787

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21837/58A Expired GB877031A (en) 1957-07-09 1958-07-08 A process for the production of natural phospholipids and related substances

Country Status (3)

Country Link
DE (1) DE1047597B (en)
GB (1) GB877031A (en)
NL (1) NL229049A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214171A (en) * 1988-12-08 1993-05-25 N.V. Vandemoortele International Process for fractionating phosphatide mixtures
US7465717B2 (en) 2004-09-27 2008-12-16 Soymor Process for releasing and extracting phosphatides from a phosphatide-containing matrix

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE617508C (en) * 1932-06-22 1935-08-20 I G Farbenindustrie Akt Ges Process for the production of pure lecithin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214171A (en) * 1988-12-08 1993-05-25 N.V. Vandemoortele International Process for fractionating phosphatide mixtures
US7465717B2 (en) 2004-09-27 2008-12-16 Soymor Process for releasing and extracting phosphatides from a phosphatide-containing matrix

Also Published As

Publication number Publication date
DE1047597B (en) 1958-12-24
NL229049A (en) 1963-07-15

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