GB856501A - Penicillin preparations - Google Patents

Penicillin preparations

Info

Publication number
GB856501A
GB856501A GB6609/59A GB660959A GB856501A GB 856501 A GB856501 A GB 856501A GB 6609/59 A GB6609/59 A GB 6609/59A GB 660959 A GB660959 A GB 660959A GB 856501 A GB856501 A GB 856501A
Authority
GB
United Kingdom
Prior art keywords
penicillin
anion
exchange material
solution
taste
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6609/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB856501A publication Critical patent/GB856501A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A penicillin preparation is manufactured by contacting an anion-exchange material with a solution of a penicillin salt, causing adsorption of the penicillin anion, and then washing with a solution of an electrolyte such as sodium chloride to remove penicillin anion (and taste thereof) from the surface of the anion-exchange material. The anion-exchange material may be apatite, kaolinite, or, preferably, a polyamine resin such as the hydrolyzed reaction product of a t-amine (e.g. trimethyl amine) and a haloalkylated copolymer of styrene and divinyl benzene. In examples the potassium salts of penicillin G and V are used. Examples V and VI illustrate the compounding of the products as pharmaceutical compositions. Specification 654,706 is referred to.ALSO:A pharmaceutical compositions comprises a penicillin preparation manufactured by contacting an anion-exchange material with a solution of a penicillin salt, causing adsorption of the penicillin anion, and then washing with a solution of an electrolyte such as sodium chloride to remove penicillin anion (and taste thereof) from the surface of the anion-exchange material. Penicillin G and V are the drugs used and the anion-exchange materials specified are the apatites, kaolinites and the reaction products of t-amines with halogenated copolymers of styrene and divinyl benzene. The resin-penicillin compounds may be put up into conventional solid and liquid forms which may be sucked, chewed or swallowed and which contain conventional excipients. Fatty bases are specifically mentioned. Specification 654,706 is referred to.
GB6609/59A 1958-11-14 1959-02-25 Penicillin preparations Expired GB856501A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA856501X 1958-11-14

Publications (1)

Publication Number Publication Date
GB856501A true GB856501A (en) 1960-12-21

Family

ID=4172706

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6609/59A Expired GB856501A (en) 1958-11-14 1959-02-25 Penicillin preparations

Country Status (1)

Country Link
GB (1) GB856501A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951953A (en) * 1973-07-10 1976-04-20 Beecham Group Limited Pharmaceutical compositions
JPS51125708A (en) * 1974-07-23 1976-11-02 Beecham Group Ltd Production of betaalactam antibiotic complex
JPH01242522A (en) * 1988-03-22 1989-09-27 Fujisawa Pharmaceut Co Ltd Suspension for internal use
US5464612A (en) * 1993-04-28 1995-11-07 Takeda Chemical Industries, Ltd. Solid preparation comprising ion exchanger and active agent
US5730999A (en) * 1993-03-27 1998-03-24 Roehm Gmbh Chemische Fabrik Dermal therapeutic system made of a meltable poly (meth) acrylate

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951953A (en) * 1973-07-10 1976-04-20 Beecham Group Limited Pharmaceutical compositions
JPS51125708A (en) * 1974-07-23 1976-11-02 Beecham Group Ltd Production of betaalactam antibiotic complex
JPH01242522A (en) * 1988-03-22 1989-09-27 Fujisawa Pharmaceut Co Ltd Suspension for internal use
JP2687401B2 (en) 1988-03-22 1997-12-08 藤沢薬品工業株式会社 Suspension for internal use
US5730999A (en) * 1993-03-27 1998-03-24 Roehm Gmbh Chemische Fabrik Dermal therapeutic system made of a meltable poly (meth) acrylate
US5464612A (en) * 1993-04-28 1995-11-07 Takeda Chemical Industries, Ltd. Solid preparation comprising ion exchanger and active agent

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